Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160092783> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2160092783 endingPage "3175" @default.
- W2160092783 startingPage "3169" @default.
- W2160092783 abstract "Cholesterol epoxide hydrolase (mCE) is a microsomal enzyme that hydrolyzes cholesterol-5,6-epoxides (CE) to cholestanetriol (CT). In the present study, hepatic mCE activity was measured in mice pretreated with several different xenobiotics known to induce a variety of hepatic drug-metabolizing enzymes. Only the phenoxyacetate hypolipidemics (clofibrate and ciprofibrate, included in the diet for 14 days) were found to increase hepatic mCE activity (1.8-fold increase). Clofibrate administration also increased rabbit hepatic (2.9-fold increase) and rat and rabbit renal mCE activity (1.5- and 2.3-fold increase respectively). On a subcellular level, mCE activities in rabbit nuclear and light mitochondrial fractions were increased (3.3- and 1.8-fold increase respectively), whereas activities in the cytosolic and heavy mitochondrial fractions were unchanged. In rabbits, clofibrate administration enhanced the hepatic microsomal hydrolysis of CE without increasing the hydrolysis of arene epoxides (benzopyrene-4,5-oxide) or fatty acid epoxides (methyl cis -9,10-epoxystearate). Increase of tissue mCE activity may significantly enhance tissue CT levels. In this light, it is worth noting similarities in the mechanisms of hypocholesterolemic action caused by cloflbrate or CT administration." @default.
- W2160092783 created "2016-06-24" @default.
- W2160092783 creator A5026538320 @default.
- W2160092783 creator A5068987782 @default.
- W2160092783 date "1988-08-01" @default.
- W2160092783 modified "2023-09-24" @default.
- W2160092783 title "Increased cholesterol epoxide hydrolase activity in clofibrate-fed animals" @default.
- W2160092783 cites W1505081213 @default.
- W2160092783 cites W1575897758 @default.
- W2160092783 cites W1581487714 @default.
- W2160092783 cites W1592313469 @default.
- W2160092783 cites W161652093 @default.
- W2160092783 cites W168132142 @default.
- W2160092783 cites W1879297302 @default.
- W2160092783 cites W1977426698 @default.
- W2160092783 cites W1979702077 @default.
- W2160092783 cites W1985968026 @default.
- W2160092783 cites W1989858978 @default.
- W2160092783 cites W2001452918 @default.
- W2160092783 cites W2001748051 @default.
- W2160092783 cites W2008692626 @default.
- W2160092783 cites W2008925886 @default.
- W2160092783 cites W2011176046 @default.
- W2160092783 cites W2021979796 @default.
- W2160092783 cites W2025790769 @default.
- W2160092783 cites W2026289095 @default.
- W2160092783 cites W2034117043 @default.
- W2160092783 cites W2034756993 @default.
- W2160092783 cites W2040290835 @default.
- W2160092783 cites W2047036603 @default.
- W2160092783 cites W2051996363 @default.
- W2160092783 cites W2060386220 @default.
- W2160092783 cites W2066321960 @default.
- W2160092783 cites W2072000403 @default.
- W2160092783 cites W2082162686 @default.
- W2160092783 cites W2082205346 @default.
- W2160092783 cites W2088482345 @default.
- W2160092783 cites W2425656378 @default.
- W2160092783 doi "https://doi.org/10.1016/0006-2952(88)90316-4" @default.
- W2160092783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3401248" @default.
- W2160092783 hasPublicationYear "1988" @default.
- W2160092783 type Work @default.
- W2160092783 sameAs 2160092783 @default.
- W2160092783 citedByCount "9" @default.
- W2160092783 crossrefType "journal-article" @default.
- W2160092783 hasAuthorship W2160092783A5026538320 @default.
- W2160092783 hasAuthorship W2160092783A5068987782 @default.
- W2160092783 hasConcept C101819947 @default.
- W2160092783 hasConcept C126322002 @default.
- W2160092783 hasConcept C134018914 @default.
- W2160092783 hasConcept C181199279 @default.
- W2160092783 hasConcept C185592680 @default.
- W2160092783 hasConcept C2778163477 @default.
- W2160092783 hasConcept C2779496979 @default.
- W2160092783 hasConcept C55493867 @default.
- W2160092783 hasConcept C71924100 @default.
- W2160092783 hasConcept C86803240 @default.
- W2160092783 hasConcept C87644729 @default.
- W2160092783 hasConcept C94412978 @default.
- W2160092783 hasConceptScore W2160092783C101819947 @default.
- W2160092783 hasConceptScore W2160092783C126322002 @default.
- W2160092783 hasConceptScore W2160092783C134018914 @default.
- W2160092783 hasConceptScore W2160092783C181199279 @default.
- W2160092783 hasConceptScore W2160092783C185592680 @default.
- W2160092783 hasConceptScore W2160092783C2778163477 @default.
- W2160092783 hasConceptScore W2160092783C2779496979 @default.
- W2160092783 hasConceptScore W2160092783C55493867 @default.
- W2160092783 hasConceptScore W2160092783C71924100 @default.
- W2160092783 hasConceptScore W2160092783C86803240 @default.
- W2160092783 hasConceptScore W2160092783C87644729 @default.
- W2160092783 hasConceptScore W2160092783C94412978 @default.
- W2160092783 hasIssue "16" @default.
- W2160092783 hasLocation W21600927831 @default.
- W2160092783 hasLocation W21600927832 @default.
- W2160092783 hasOpenAccess W2160092783 @default.
- W2160092783 hasPrimaryLocation W21600927831 @default.
- W2160092783 hasRelatedWork W1971830642 @default.
- W2160092783 hasRelatedWork W1998913035 @default.
- W2160092783 hasRelatedWork W2003121798 @default.
- W2160092783 hasRelatedWork W2005998106 @default.
- W2160092783 hasRelatedWork W2030400955 @default.
- W2160092783 hasRelatedWork W2032958076 @default.
- W2160092783 hasRelatedWork W2035331946 @default.
- W2160092783 hasRelatedWork W2075372262 @default.
- W2160092783 hasRelatedWork W2118790180 @default.
- W2160092783 hasRelatedWork W2398696055 @default.
- W2160092783 hasVolume "37" @default.
- W2160092783 isParatext "false" @default.
- W2160092783 isRetracted "false" @default.
- W2160092783 magId "2160092783" @default.
- W2160092783 workType "article" @default.