FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160099462> ?p ?o ?g. }

• W2160099462 endingPage "4550" @default.
• W2160099462 startingPage "4542" @default.
• W2160099462 abstract "The hypoxia-inducible factor-1 (HIF-1) was first described as a DNA binding activity that specifically recognizes an 8 bp motif known to be essential for hypoxia-inducible erythropoietin gene transcription. Subsequently HIF-1 activity has also been found in cell lines which do not express erythropoietin, suggesting that HIF-1 is part of a widespread oxygen sensing mechanism. In electrophoretic mobility shift assays HIF-1 DNA binding activity is only detectable in nuclear extracts of cells cultivated in a low oxygen atmosphere. In addition to HIF-1, a constitutive DNA binding activity also specifically binds the HIF1 probe. Here we report that CRE and AP1 oligonucleotides efficiently competed for binding of the HIF1 probe to this constitutive factor, whereas HIF-1 activity itself remained unaffected. Monoclonal antibodies raised against the CRE binding factors ATF-1 and CREB-1 supershifted the constitutive factors ATF-1 and CREB-1 supershifted the constitutive factor, while Jun and Fos family members, which constitute the AP-1 factor, were immunologically undetectable. Recombinant ATF-1 and CREB-1 proteins bound HIF1 probes either as homodimers or as heterodimers, indicating a new binding specificity for ATF-1/CREB-1. Finally, reporter gene assays in HeLa cells treated with either a cAMP analogue or a phorbol ester suggest that the PKA, but not the PKC signalling pathway is involved in oxygen sensing." @default.
• W2160099462 created "2016-06-24" @default.
• W2160099462 creator A5014391609 @default.
• W2160099462 creator A5037254031 @default.
• W2160099462 creator A5054613155 @default.
• W2160099462 creator A5089030267 @default.
• W2160099462 date "1995-01-01" @default.
• W2160099462 modified "2023-10-12" @default.
• W2160099462 title "The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1)DNA recognition site" @default.
• W2160099462 cites W1485104973 @default.
• W2160099462 cites W1503667331 @default.
• W2160099462 cites W1521696202 @default.
• W2160099462 cites W1545825939 @default.
• W2160099462 cites W1721827275 @default.
• W2160099462 cites W1951047070 @default.
• W2160099462 cites W1970290216 @default.
• W2160099462 cites W1979551064 @default.
• W2160099462 cites W1988403143 @default.
• W2160099462 cites W1990989603 @default.
• W2160099462 cites W2009310436 @default.
• W2160099462 cites W2019289959 @default.
• W2160099462 cites W2023666553 @default.
• W2160099462 cites W2023771888 @default.
• W2160099462 cites W2024206845 @default.
• W2160099462 cites W2028285437 @default.
• W2160099462 cites W2038449972 @default.
• W2160099462 cites W2039579801 @default.
• W2160099462 cites W2047361593 @default.
• W2160099462 cites W2052386670 @default.
• W2160099462 cites W2053196200 @default.
• W2160099462 cites W2056850109 @default.
• W2160099462 cites W2072839085 @default.
• W2160099462 cites W2081999200 @default.
• W2160099462 cites W2082197167 @default.
• W2160099462 cites W2082584138 @default.
• W2160099462 cites W2085609942 @default.
• W2160099462 cites W2090627731 @default.
• W2160099462 cites W2135836641 @default.
• W2160099462 cites W2136210811 @default.
• W2160099462 cites W2144226840 @default.
• W2160099462 cites W2336116827 @default.
• W2160099462 cites W2461751497 @default.
• W2160099462 cites W2580449060 @default.
• W2160099462 cites W2584947097 @default.
• W2160099462 doi "https://doi.org/10.1093/nar/23.22.4542" @default.
• W2160099462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/307423" @default.
• W2160099462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8524640" @default.
• W2160099462 hasPublicationYear "1995" @default.
• W2160099462 type Work @default.
• W2160099462 sameAs 2160099462 @default.
• W2160099462 citedByCount "217" @default.
• W2160099462 countsByYear W21600994622012 @default.
• W2160099462 countsByYear W21600994622013 @default.
• W2160099462 countsByYear W21600994622014 @default.
• W2160099462 countsByYear W21600994622015 @default.
• W2160099462 countsByYear W21600994622016 @default.
• W2160099462 countsByYear W21600994622017 @default.
• W2160099462 countsByYear W21600994622018 @default.
• W2160099462 countsByYear W21600994622019 @default.
• W2160099462 countsByYear W21600994622020 @default.
• W2160099462 countsByYear W21600994622021 @default.
• W2160099462 countsByYear W21600994622022 @default.
• W2160099462 crossrefType "journal-article" @default.
• W2160099462 hasAuthorship W2160099462A5014391609 @default.
• W2160099462 hasAuthorship W2160099462A5037254031 @default.
• W2160099462 hasAuthorship W2160099462A5054613155 @default.
• W2160099462 hasAuthorship W2160099462A5089030267 @default.
• W2160099462 hasBestOaLocation W21600994621 @default.
• W2160099462 hasConcept C101762097 @default.
• W2160099462 hasConcept C102280478 @default.
• W2160099462 hasConcept C104317684 @default.
• W2160099462 hasConcept C107824862 @default.
• W2160099462 hasConcept C132376346 @default.
• W2160099462 hasConcept C150194340 @default.
• W2160099462 hasConcept C153911025 @default.
• W2160099462 hasConcept C160450060 @default.
• W2160099462 hasConcept C1629964 @default.
• W2160099462 hasConcept C183978625 @default.
• W2160099462 hasConcept C2778534260 @default.
• W2160099462 hasConcept C2909511254 @default.
• W2160099462 hasConcept C54355233 @default.
• W2160099462 hasConcept C55493867 @default.
• W2160099462 hasConcept C77179829 @default.
• W2160099462 hasConcept C86339819 @default.
• W2160099462 hasConcept C86803240 @default.
• W2160099462 hasConcept C94966510 @default.
• W2160099462 hasConcept C95444343 @default.
• W2160099462 hasConceptScore W2160099462C101762097 @default.
• W2160099462 hasConceptScore W2160099462C102280478 @default.
• W2160099462 hasConceptScore W2160099462C104317684 @default.
• W2160099462 hasConceptScore W2160099462C107824862 @default.
• W2160099462 hasConceptScore W2160099462C132376346 @default.
• W2160099462 hasConceptScore W2160099462C150194340 @default.
• W2160099462 hasConceptScore W2160099462C153911025 @default.
• W2160099462 hasConceptScore W2160099462C160450060 @default.
• W2160099462 hasConceptScore W2160099462C1629964 @default.
• W2160099462 hasConceptScore W2160099462C183978625 @default.
• W2160099462 hasConceptScore W2160099462C2778534260 @default.

• next