FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160132598> ?p ?o ?g. }

• W2160132598 abstract "X-box-binding protein 1 (XBP1) is an important regulator of a subset of genes active during endoplasmic reticulum (ER) stress. In the present study, we analyzed XBP1 level and location to explore the effect of ER stress on oocyte maturation and developmental competency of porcine embryos in an in vitro culture system. First, we examined the localization of XBP1 at different meiotic stages of porcine oocytes and at early stages of parthenogenetic embryo development. Fluorescence staining showed that expression of functional XBP1 was weak in mature oocytes and at the 1-, 2-, and 8-cell stages of embryos but abundant at the germinal vesicle (GV), 4-cell, morula, and blastocyst stages. In addition, RT-PCR revealed that both spliced XBP1 (XBP1-s) and unspliced XBP1 (XBP1-u) were expressed at the GV, 4-cell, morula, and blastocyst stages. Tunicamycin, an ER stress inducer, induced active XBP1 protein in nuclei of 4-cell embryos. Next, porcine embryos cultured in the presence of tauroursodeoxycholate, an ER stress inhibitor, were studied. Total cell numbers and the extent of the inner cell mass increased (P < 0.05), whereas the rate of nuclear apoptosis decreased (P < 0.05). Moreover, expression of the antiapoptotic gene BCL2 increased, whereas expression of the proapoptotic genes BCL2L1 (Bcl-xl) and TP53 decreased. The results indicated that inhibition of ER stress enhanced porcine oocyte maturation and embryonic development by preventing ER stress-mediated apoptosis in vitro." @default.
• W2160132598 created "2016-06-24" @default.
• W2160132598 creator A5050292482 @default.
• W2160132598 creator A5057821011 @default.
• W2160132598 creator A5067232234 @default.
• W2160132598 creator A5078028001 @default.
• W2160132598 creator A5078669547 @default.
• W2160132598 date "2012-04-01" @default.
• W2160132598 modified "2023-10-07" @default.
• W2160132598 title "Effect of Endoplasmic Reticulum Stress on Porcine Oocyte Maturation and Parthenogenetic Embryonic Development In Vitro1" @default.
• W2160132598 cites W1644794975 @default.
• W2160132598 cites W1911421926 @default.
• W2160132598 cites W1967373897 @default.
• W2160132598 cites W1970090817 @default.
• W2160132598 cites W1973676077 @default.
• W2160132598 cites W198432786 @default.
• W2160132598 cites W1984403764 @default.
• W2160132598 cites W1986737010 @default.
• W2160132598 cites W1991319495 @default.
• W2160132598 cites W1998164990 @default.
• W2160132598 cites W1998562057 @default.
• W2160132598 cites W2007146753 @default.
• W2160132598 cites W2014359260 @default.
• W2160132598 cites W2026336054 @default.
• W2160132598 cites W2027543816 @default.
• W2160132598 cites W2029329181 @default.
• W2160132598 cites W2034306618 @default.
• W2160132598 cites W2048831569 @default.
• W2160132598 cites W2054128877 @default.
• W2160132598 cites W2059219207 @default.
• W2160132598 cites W2062918974 @default.
• W2160132598 cites W2066796380 @default.
• W2160132598 cites W2069848370 @default.
• W2160132598 cites W2070389094 @default.
• W2160132598 cites W2076880493 @default.
• W2160132598 cites W2079944569 @default.
• W2160132598 cites W2083865116 @default.
• W2160132598 cites W2086365629 @default.
• W2160132598 cites W2089124271 @default.
• W2160132598 cites W2089198803 @default.
• W2160132598 cites W2094274061 @default.
• W2160132598 cites W2094908106 @default.
• W2160132598 cites W2104106827 @default.
• W2160132598 cites W2106314483 @default.
• W2160132598 cites W2107601804 @default.
• W2160132598 cites W2110797810 @default.
• W2160132598 cites W2126294194 @default.
• W2160132598 cites W2127906377 @default.
• W2160132598 cites W2140277678 @default.
• W2160132598 cites W2147351410 @default.
• W2160132598 cites W2152398979 @default.
• W2160132598 cites W2156701434 @default.
• W2160132598 cites W2157355797 @default.
• W2160132598 cites W2161083011 @default.
• W2160132598 cites W2162797237 @default.
• W2160132598 cites W2165796896 @default.
• W2160132598 doi "https://doi.org/10.1095/biolreprod.111.095059" @default.
• W2160132598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22190710" @default.
• W2160132598 hasPublicationYear "2012" @default.
• W2160132598 type Work @default.
• W2160132598 sameAs 2160132598 @default.
• W2160132598 citedByCount "61" @default.
• W2160132598 countsByYear W21601325982013 @default.
• W2160132598 countsByYear W21601325982014 @default.
• W2160132598 countsByYear W21601325982015 @default.
• W2160132598 countsByYear W21601325982016 @default.
• W2160132598 countsByYear W21601325982017 @default.
• W2160132598 countsByYear W21601325982018 @default.
• W2160132598 countsByYear W21601325982019 @default.
• W2160132598 countsByYear W21601325982020 @default.
• W2160132598 countsByYear W21601325982021 @default.
• W2160132598 countsByYear W21601325982022 @default.
• W2160132598 countsByYear W21601325982023 @default.
• W2160132598 crossrefType "journal-article" @default.
• W2160132598 hasAuthorship W2160132598A5050292482 @default.
• W2160132598 hasAuthorship W2160132598A5057821011 @default.
• W2160132598 hasAuthorship W2160132598A5067232234 @default.
• W2160132598 hasAuthorship W2160132598A5078028001 @default.
• W2160132598 hasAuthorship W2160132598A5078669547 @default.
• W2160132598 hasBestOaLocation W21601325981 @default.
• W2160132598 hasConcept C104317684 @default.
• W2160132598 hasConcept C139447449 @default.
• W2160132598 hasConcept C153911025 @default.
• W2160132598 hasConcept C158617107 @default.
• W2160132598 hasConcept C159399396 @default.
• W2160132598 hasConcept C196843134 @default.
• W2160132598 hasConcept C2775966511 @default.
• W2160132598 hasConcept C2776690073 @default.
• W2160132598 hasConcept C2778177303 @default.
• W2160132598 hasConcept C2781331208 @default.
• W2160132598 hasConcept C54355233 @default.
• W2160132598 hasConcept C54458228 @default.
• W2160132598 hasConcept C67705224 @default.
• W2160132598 hasConcept C86803240 @default.
• W2160132598 hasConcept C87073359 @default.
• W2160132598 hasConcept C95444343 @default.
• W2160132598 hasConceptScore W2160132598C104317684 @default.
• W2160132598 hasConceptScore W2160132598C139447449 @default.
• W2160132598 hasConceptScore W2160132598C153911025 @default.
• W2160132598 hasConceptScore W2160132598C158617107 @default.

• next