FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160135477> ?p ?o ?g. }

• W2160135477 endingPage "10424" @default.
• W2160135477 startingPage "10413" @default.
• W2160135477 abstract "The title compounds are a class of structurally simple analogues of quaternary benzo[c]phenanthridine alkaloids (QBAs). In order to develop novel QBA-like antifungal drugs, in this study, 24 of the title compounds with various substituents on the N-phenyl ring were evaluated for bioactivity against seven phytopathogenic fungi using the mycelial growth rate method and their SAR discussed. Almost all the compounds showed definite activities in vitro against each of the test fungi at 50 μg/mL and a broad antifungal spectrum. In most cases, the mono-halogenated compounds 2–12 exhibited excellent activities superior to the QBAs sanguinarine and chelerythrine. Compound 8 possessed the strongest activities on each of the fungi with EC50 values of 8.88–19.88 µg/mL and a significant concentration-dependent relationship. The SAR is as follows: the N-phenyl group is a high sensitive structural moiety for the activity and the characteristics and position of substituents intensively influence the activity. Generally, electron-withdrawing substituents remarkably enhance the activity while electron-donating substituents cause a decrease of the activity. In most cases, ortha- and para-halogenated isomers were more active than the corresponding m-halogenated isomers. Thus, the title compounds emerged as promising lead compounds for the development of novel biomimetic antifungal agrochemicals. Compounds 8 and 2 should have great potential as new broad spectrum antifungal agents for plant protection." @default.
• W2160135477 created "2016-06-24" @default.
• W2160135477 creator A5001817156 @default.
• W2160135477 creator A5029964155 @default.
• W2160135477 creator A5044463543 @default.
• W2160135477 creator A5050180063 @default.
• W2160135477 creator A5064501760 @default.
• W2160135477 creator A5066038963 @default.
• W2160135477 creator A5075757992 @default.
• W2160135477 date "2013-08-29" @default.
• W2160135477 modified "2023-10-09" @default.
• W2160135477 title "2-(Substituted phenyl)-3,4-dihydroisoquinolin-2-iums as Novel Antifungal Lead Compounds: Biological Evaluation and Structure-Activity Relationships" @default.
• W2160135477 cites W1597919725 @default.
• W2160135477 cites W1989330850 @default.
• W2160135477 cites W1999307291 @default.
• W2160135477 cites W2018696862 @default.
• W2160135477 cites W2022576539 @default.
• W2160135477 cites W2033711500 @default.
• W2160135477 cites W2036372490 @default.
• W2160135477 cites W2038789175 @default.
• W2160135477 cites W2042053417 @default.
• W2160135477 cites W2042747700 @default.
• W2160135477 cites W2047015970 @default.
• W2160135477 cites W2060985065 @default.
• W2160135477 cites W2079593468 @default.
• W2160135477 cites W2094215050 @default.
• W2160135477 cites W2095444903 @default.
• W2160135477 cites W2126430706 @default.
• W2160135477 cites W2137359739 @default.
• W2160135477 cites W2149327830 @default.
• W2160135477 cites W2171510042 @default.
• W2160135477 cites W2308604109 @default.
• W2160135477 doi "https://doi.org/10.3390/molecules180910413" @default.
• W2160135477 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6269970" @default.
• W2160135477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23994968" @default.
• W2160135477 hasPublicationYear "2013" @default.
• W2160135477 type Work @default.
• W2160135477 sameAs 2160135477 @default.
• W2160135477 citedByCount "34" @default.
• W2160135477 countsByYear W21601354772014 @default.
• W2160135477 countsByYear W21601354772015 @default.
• W2160135477 countsByYear W21601354772016 @default.
• W2160135477 countsByYear W21601354772017 @default.
• W2160135477 countsByYear W21601354772018 @default.
• W2160135477 countsByYear W21601354772019 @default.
• W2160135477 countsByYear W21601354772020 @default.
• W2160135477 countsByYear W21601354772022 @default.
• W2160135477 countsByYear W21601354772023 @default.
• W2160135477 crossrefType "journal-article" @default.
• W2160135477 hasAuthorship W2160135477A5001817156 @default.
• W2160135477 hasAuthorship W2160135477A5029964155 @default.
• W2160135477 hasAuthorship W2160135477A5044463543 @default.
• W2160135477 hasAuthorship W2160135477A5050180063 @default.
• W2160135477 hasAuthorship W2160135477A5064501760 @default.
• W2160135477 hasAuthorship W2160135477A5066038963 @default.
• W2160135477 hasAuthorship W2160135477A5075757992 @default.
• W2160135477 hasBestOaLocation W21601354771 @default.
• W2160135477 hasConcept C116073593 @default.
• W2160135477 hasConcept C133479454 @default.
• W2160135477 hasConcept C178790620 @default.
• W2160135477 hasConcept C181199279 @default.
• W2160135477 hasConcept C185592680 @default.
• W2160135477 hasConcept C195794163 @default.
• W2160135477 hasConcept C202751555 @default.
• W2160135477 hasConcept C2776108454 @default.
• W2160135477 hasConcept C2776568683 @default.
• W2160135477 hasConcept C2777752112 @default.
• W2160135477 hasConcept C2779548794 @default.
• W2160135477 hasConcept C2780185047 @default.
• W2160135477 hasConcept C55493867 @default.
• W2160135477 hasConcept C59822182 @default.
• W2160135477 hasConcept C71240020 @default.
• W2160135477 hasConcept C86803240 @default.
• W2160135477 hasConcept C89423630 @default.
• W2160135477 hasConcept C96529984 @default.
• W2160135477 hasConceptScore W2160135477C116073593 @default.
• W2160135477 hasConceptScore W2160135477C133479454 @default.
• W2160135477 hasConceptScore W2160135477C178790620 @default.
• W2160135477 hasConceptScore W2160135477C181199279 @default.
• W2160135477 hasConceptScore W2160135477C185592680 @default.
• W2160135477 hasConceptScore W2160135477C195794163 @default.
• W2160135477 hasConceptScore W2160135477C202751555 @default.
• W2160135477 hasConceptScore W2160135477C2776108454 @default.
• W2160135477 hasConceptScore W2160135477C2776568683 @default.
• W2160135477 hasConceptScore W2160135477C2777752112 @default.
• W2160135477 hasConceptScore W2160135477C2779548794 @default.
• W2160135477 hasConceptScore W2160135477C2780185047 @default.
• W2160135477 hasConceptScore W2160135477C55493867 @default.
• W2160135477 hasConceptScore W2160135477C59822182 @default.
• W2160135477 hasConceptScore W2160135477C71240020 @default.
• W2160135477 hasConceptScore W2160135477C86803240 @default.
• W2160135477 hasConceptScore W2160135477C89423630 @default.
• W2160135477 hasConceptScore W2160135477C96529984 @default.
• W2160135477 hasIssue "9" @default.
• W2160135477 hasLocation W21601354771 @default.
• W2160135477 hasLocation W21601354772 @default.
• W2160135477 hasLocation W21601354773 @default.
• W2160135477 hasLocation W21601354774 @default.

• next