FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160147190> ?p ?o ?g. }

• W2160147190 endingPage "748" @default.
• W2160147190 startingPage "739" @default.
• W2160147190 abstract "Abstract Purpose: KRAS is the most commonly mutated oncogene in human tumors. KRAS-mutant cells may exhibit resistance to the allosteric MEK1/2 inhibitor selumetinib (AZD6244; ARRY-142886) and allosteric AKT inhibitors (such as MK-2206), the combination of which may overcome resistance to both monotherapies. Experimental Design: We conducted a dose/schedule-finding study evaluating MK-2206 and selumetinib in patients with advanced treatment-refractory solid tumors. Recommended dosing schedules were defined as MK-2206 at 135 mg weekly and selumetinib at 100 mg once daily. Results: Grade 3 rash was the most common dose-limiting toxicity (DLT); other DLTs included grade 4 lipase increase, grade 3 stomatitis, diarrhea, and fatigue, and grade 3 and grade 2 retinal pigment epithelium detachment. There were no meaningful pharmacokinetic drug–drug interactions. Clinical antitumor activity included RECIST 1.0–confirmed partial responses in non–small cell lung cancer and low-grade ovarian carcinoma. Conclusion: Responses in KRAS-mutant cancers were generally durable. Clinical cotargeting of MEK and AKT signaling may be an important therapeutic strategy in KRAS-driven human malignancies (Trial NCT number NCT01021748). Clin Cancer Res; 21(4); 739–48. ©2014 AACR." @default.
• W2160147190 created "2016-06-24" @default.
• W2160147190 creator A5006299989 @default.
• W2160147190 creator A5008790176 @default.
• W2160147190 creator A5012970737 @default.
• W2160147190 creator A5022467575 @default.
• W2160147190 creator A5032401979 @default.
• W2160147190 creator A5036091074 @default.
• W2160147190 creator A5037530844 @default.
• W2160147190 creator A5038010720 @default.
• W2160147190 creator A5052027970 @default.
• W2160147190 creator A5060097236 @default.
• W2160147190 creator A5060992997 @default.
• W2160147190 creator A5067915183 @default.
• W2160147190 creator A5068368047 @default.
• W2160147190 creator A5070570779 @default.
• W2160147190 creator A5070937556 @default.
• W2160147190 creator A5071341853 @default.
• W2160147190 creator A5072116005 @default.
• W2160147190 creator A5072378199 @default.
• W2160147190 creator A5074861706 @default.
• W2160147190 creator A5075285660 @default.
• W2160147190 creator A5079895979 @default.
• W2160147190 creator A5080215197 @default.
• W2160147190 creator A5081614843 @default.
• W2160147190 creator A5081867528 @default.
• W2160147190 creator A5086094365 @default.
• W2160147190 date "2015-02-15" @default.
• W2160147190 modified "2023-10-10" @default.
• W2160147190 title "Antitumor Activity in <i>RAS</i>-Driven Tumors by Blocking AKT and MEK" @default.
• W2160147190 cites W1970527559 @default.
• W2160147190 cites W1971617980 @default.
• W2160147190 cites W2001999652 @default.
• W2160147190 cites W2013191667 @default.
• W2160147190 cites W2014096417 @default.
• W2160147190 cites W2014881369 @default.
• W2160147190 cites W2023696468 @default.
• W2160147190 cites W2027114592 @default.
• W2160147190 cites W2036276565 @default.
• W2160147190 cites W2051841073 @default.
• W2160147190 cites W2061061337 @default.
• W2160147190 cites W2077945404 @default.
• W2160147190 cites W2080719056 @default.
• W2160147190 cites W2084875329 @default.
• W2160147190 cites W2099129819 @default.
• W2160147190 cites W2108517627 @default.
• W2160147190 cites W2110528825 @default.
• W2160147190 cites W2114621192 @default.
• W2160147190 cites W2114784462 @default.
• W2160147190 cites W2119754956 @default.
• W2160147190 cites W2120492882 @default.
• W2160147190 cites W2122476809 @default.
• W2160147190 cites W2129400742 @default.
• W2160147190 cites W2131564236 @default.
• W2160147190 cites W2134964552 @default.
• W2160147190 cites W2139248078 @default.
• W2160147190 cites W2167162853 @default.
• W2160147190 cites W2171972386 @default.
• W2160147190 cites W2466381983 @default.
• W2160147190 cites W2520717841 @default.
• W2160147190 doi "https://doi.org/10.1158/1078-0432.ccr-14-1901" @default.
• W2160147190 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4335074" @default.
• W2160147190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25516890" @default.
• W2160147190 hasPublicationYear "2015" @default.
• W2160147190 type Work @default.
• W2160147190 sameAs 2160147190 @default.
• W2160147190 citedByCount "118" @default.
• W2160147190 countsByYear W21601471902015 @default.
• W2160147190 countsByYear W21601471902016 @default.
• W2160147190 countsByYear W21601471902017 @default.
• W2160147190 countsByYear W21601471902018 @default.
• W2160147190 countsByYear W21601471902019 @default.
• W2160147190 countsByYear W21601471902020 @default.
• W2160147190 countsByYear W21601471902021 @default.
• W2160147190 countsByYear W21601471902022 @default.
• W2160147190 countsByYear W21601471902023 @default.
• W2160147190 crossrefType "journal-article" @default.
• W2160147190 hasAuthorship W2160147190A5006299989 @default.
• W2160147190 hasAuthorship W2160147190A5008790176 @default.
• W2160147190 hasAuthorship W2160147190A5012970737 @default.
• W2160147190 hasAuthorship W2160147190A5022467575 @default.
• W2160147190 hasAuthorship W2160147190A5032401979 @default.
• W2160147190 hasAuthorship W2160147190A5036091074 @default.
• W2160147190 hasAuthorship W2160147190A5037530844 @default.
• W2160147190 hasAuthorship W2160147190A5038010720 @default.
• W2160147190 hasAuthorship W2160147190A5052027970 @default.
• W2160147190 hasAuthorship W2160147190A5060097236 @default.
• W2160147190 hasAuthorship W2160147190A5060992997 @default.
• W2160147190 hasAuthorship W2160147190A5067915183 @default.
• W2160147190 hasAuthorship W2160147190A5068368047 @default.
• W2160147190 hasAuthorship W2160147190A5070570779 @default.
• W2160147190 hasAuthorship W2160147190A5070937556 @default.
• W2160147190 hasAuthorship W2160147190A5071341853 @default.
• W2160147190 hasAuthorship W2160147190A5072116005 @default.
• W2160147190 hasAuthorship W2160147190A5072378199 @default.
• W2160147190 hasAuthorship W2160147190A5074861706 @default.
• W2160147190 hasAuthorship W2160147190A5075285660 @default.
• W2160147190 hasAuthorship W2160147190A5079895979 @default.

• next