Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160167013> ?p ?o ?g. }
- W2160167013 abstract "Oncolytic viruses (OV) are a class of antitumor agents that selectively kill tumor cells while sparing normal cells. Oncolytic herpes simplex virus (oHSV) has been investigated in clinical trials for patients with the malignant brain tumor glioblastoma for more than a decade. These clinical studies have shown the safety of oHSV administration to the human brain, however, therapeutic efficacy of oHSV as a single treatment remains unsatisfactory. Factors that could hamper the anti-glioblastoma efficacy of oHSV include: attenuated potency of oHSV due to deletion or mutation of viral genes involved in virulence, restricting viral replication and spread within the tumor; suboptimal oHSV delivery associated with intratumoral injection; virus infection-induced inflammatory and cellular immune responses which could inhibit oHSV replication and promote its clearance; lack of effective incorporation of oHSV into standard-of-care, and poor knowledge about the ability of oHSV to target glioblastoma stem cells (GSCs). In an attempt to address these issues, recent research efforts have been directed at: (1) design of new engineered viruses to enhance potency, (2) better understanding of the role of the cellular immunity elicited by oHSV infection of tumors, (3) combinatorial strategies with different antitumor agents with a mechanistic rationale, (4) armed viruses expressing therapeutic transgenes, (5) use of GSC-derived models in oHSV evaluation, and (6) combinations of these. In this review, we will describe the current status of oHSV clinical trials for glioblastoma, and discuss recent research advances and future directions toward successful oHSV-based therapy of glioblastoma." @default.
- W2160167013 created "2016-06-24" @default.
- W2160167013 creator A5006633218 @default.
- W2160167013 creator A5038096872 @default.
- W2160167013 date "2014-06-20" @default.
- W2160167013 modified "2023-09-25" @default.
- W2160167013 title "Oncolytic herpes simplex virus-based strategies: toward a breakthrough in glioblastoma therapy" @default.
- W2160167013 cites W1225417585 @default.
- W2160167013 cites W1559374697 @default.
- W2160167013 cites W181785431 @default.
- W2160167013 cites W1970212185 @default.
- W2160167013 cites W1971532562 @default.
- W2160167013 cites W1972887015 @default.
- W2160167013 cites W1973202695 @default.
- W2160167013 cites W1974489757 @default.
- W2160167013 cites W1980030143 @default.
- W2160167013 cites W1983766005 @default.
- W2160167013 cites W1986536654 @default.
- W2160167013 cites W1987741335 @default.
- W2160167013 cites W1988658787 @default.
- W2160167013 cites W1991883188 @default.
- W2160167013 cites W1992144732 @default.
- W2160167013 cites W1994778014 @default.
- W2160167013 cites W1997747808 @default.
- W2160167013 cites W1998933123 @default.
- W2160167013 cites W1999096842 @default.
- W2160167013 cites W2000551060 @default.
- W2160167013 cites W2001753204 @default.
- W2160167013 cites W2002613587 @default.
- W2160167013 cites W2004334494 @default.
- W2160167013 cites W2005371778 @default.
- W2160167013 cites W2008393860 @default.
- W2160167013 cites W2009282514 @default.
- W2160167013 cites W2013028886 @default.
- W2160167013 cites W2015613327 @default.
- W2160167013 cites W2018535642 @default.
- W2160167013 cites W2018648852 @default.
- W2160167013 cites W2019034425 @default.
- W2160167013 cites W2022472349 @default.
- W2160167013 cites W2023708410 @default.
- W2160167013 cites W2025568235 @default.
- W2160167013 cites W2026406742 @default.
- W2160167013 cites W2026486274 @default.
- W2160167013 cites W2031714805 @default.
- W2160167013 cites W2032672495 @default.
- W2160167013 cites W2035880310 @default.
- W2160167013 cites W2036044314 @default.
- W2160167013 cites W2036083442 @default.
- W2160167013 cites W2037044453 @default.
- W2160167013 cites W2037171350 @default.
- W2160167013 cites W2038709470 @default.
- W2160167013 cites W2039075677 @default.
- W2160167013 cites W2039317622 @default.
- W2160167013 cites W2039741910 @default.
- W2160167013 cites W2040827479 @default.
- W2160167013 cites W2045310122 @default.
- W2160167013 cites W2045616069 @default.
- W2160167013 cites W2047483768 @default.
- W2160167013 cites W2049092411 @default.
- W2160167013 cites W2050216826 @default.
- W2160167013 cites W2050921603 @default.
- W2160167013 cites W2051257242 @default.
- W2160167013 cites W2052110007 @default.
- W2160167013 cites W2054319806 @default.
- W2160167013 cites W2057382033 @default.
- W2160167013 cites W2058660954 @default.
- W2160167013 cites W2058734972 @default.
- W2160167013 cites W2060922355 @default.
- W2160167013 cites W2064203915 @default.
- W2160167013 cites W2065647961 @default.
- W2160167013 cites W2066267613 @default.
- W2160167013 cites W2067211964 @default.
- W2160167013 cites W2068268112 @default.
- W2160167013 cites W2070766828 @default.
- W2160167013 cites W2071151466 @default.
- W2160167013 cites W2073134590 @default.
- W2160167013 cites W2074111828 @default.
- W2160167013 cites W2075886869 @default.
- W2160167013 cites W2079510823 @default.
- W2160167013 cites W2079935861 @default.
- W2160167013 cites W2082150850 @default.
- W2160167013 cites W2083100228 @default.
- W2160167013 cites W2086011860 @default.
- W2160167013 cites W2088446904 @default.
- W2160167013 cites W2089327513 @default.
- W2160167013 cites W2092905994 @default.
- W2160167013 cites W2094949672 @default.
- W2160167013 cites W2096287682 @default.
- W2160167013 cites W2098308748 @default.
- W2160167013 cites W2100668772 @default.
- W2160167013 cites W2104348730 @default.
- W2160167013 cites W2104605014 @default.
- W2160167013 cites W2106161829 @default.
- W2160167013 cites W2112326573 @default.
- W2160167013 cites W2118312408 @default.
- W2160167013 cites W2118375737 @default.
- W2160167013 cites W2119593356 @default.
- W2160167013 cites W2121170253 @default.
- W2160167013 cites W2121191294 @default.
- W2160167013 cites W2124736921 @default.