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- W2160171594 endingPage "3435" @default.
- W2160171594 startingPage "3427" @default.
- W2160171594 abstract "The arsenal of treatments for most cancers fit broadly into the categories of surgery, chemotherapy, radiation, and targeted therapy. All represent proven and successful strategies, yet each can trigger local (tumor) and systemic (host) processes that elicit unwanted, often opposing, influences on cancer growth. Under certain conditions, nearly all cancer treatments can facilitate metastatic spread, often in parallel (and sometimes in clear contrast) with tumor reducing benefits. The paradox of treatment-induced metastasis (TIM) is not new. Supporting preclinical studies span decades, but are often overlooked. With recent evidence of prometastatic effects following treatment with targeted agents blocking the tumor microenvironment, a closer inspection of this literature is warranted. The TIM phenomena may diminish the impact of effective therapies and play a critical role in eventual resistance. Alternatively, it may simply exemplify the gap between animal and human studies, and therefore have little impact for patient disease and treatment. This review will focus on the preclinical model systems used to evaluate TIM and explore the mechanisms that influence overall treatment efficacy. Understanding the role of TIM in established and emerging drug treatment strategies may help provide rationales for future drug combination approaches with antimetastatic agents to improve outcomes and reduce resistance." @default.
- W2160171594 created "2016-06-24" @default.
- W2160171594 creator A5009195551 @default.
- W2160171594 date "2015-08-31" @default.
- W2160171594 modified "2023-09-27" @default.
- W2160171594 title "Prodding the Beast: Assessing the Impact of Treatment-Induced Metastasis" @default.
- W2160171594 cites W1218170828 @default.
- W2160171594 cites W1481099429 @default.
- W2160171594 cites W1519477593 @default.
- W2160171594 cites W1642961656 @default.
- W2160171594 cites W1904840155 @default.
- W2160171594 cites W1948600523 @default.
- W2160171594 cites W1950865010 @default.
- W2160171594 cites W1963904011 @default.
- W2160171594 cites W1965388436 @default.
- W2160171594 cites W1965948542 @default.
- W2160171594 cites W1966767864 @default.
- W2160171594 cites W1967156882 @default.
- W2160171594 cites W1967600348 @default.
- W2160171594 cites W1972176022 @default.
- W2160171594 cites W1973924350 @default.
- W2160171594 cites W1975273764 @default.
- W2160171594 cites W1978953774 @default.
- W2160171594 cites W1980618392 @default.
- W2160171594 cites W1981033124 @default.
- W2160171594 cites W1981211047 @default.
- W2160171594 cites W1982147571 @default.
- W2160171594 cites W1982441587 @default.
- W2160171594 cites W1982478308 @default.
- W2160171594 cites W1984514300 @default.
- W2160171594 cites W1984804749 @default.
- W2160171594 cites W1985549756 @default.
- W2160171594 cites W1985727076 @default.
- W2160171594 cites W1989497964 @default.
- W2160171594 cites W1992734238 @default.
- W2160171594 cites W1993799976 @default.
- W2160171594 cites W1997299298 @default.
- W2160171594 cites W1997724723 @default.
- W2160171594 cites W1998751474 @default.
- W2160171594 cites W1999610552 @default.
- W2160171594 cites W1999880569 @default.
- W2160171594 cites W2004189275 @default.
- W2160171594 cites W2005115964 @default.
- W2160171594 cites W2009827612 @default.
- W2160171594 cites W2010570319 @default.
- W2160171594 cites W2011765548 @default.
- W2160171594 cites W2012091996 @default.
- W2160171594 cites W2017056838 @default.
- W2160171594 cites W2019859553 @default.
- W2160171594 cites W2022540958 @default.
- W2160171594 cites W2023067487 @default.
- W2160171594 cites W2023075736 @default.
- W2160171594 cites W2026652849 @default.
- W2160171594 cites W2026905829 @default.
- W2160171594 cites W2027123549 @default.
- W2160171594 cites W2027335594 @default.
- W2160171594 cites W2028435743 @default.
- W2160171594 cites W2032223125 @default.
- W2160171594 cites W2034017959 @default.
- W2160171594 cites W2034394424 @default.
- W2160171594 cites W2035971989 @default.
- W2160171594 cites W2039013742 @default.
- W2160171594 cites W2039097790 @default.
- W2160171594 cites W2041312958 @default.
- W2160171594 cites W2041353769 @default.
- W2160171594 cites W2044905529 @default.
- W2160171594 cites W2045389113 @default.
- W2160171594 cites W2046239861 @default.
- W2160171594 cites W2046374386 @default.
- W2160171594 cites W2051628687 @default.
- W2160171594 cites W2055374213 @default.
- W2160171594 cites W2055653548 @default.
- W2160171594 cites W2058274698 @default.
- W2160171594 cites W2059099021 @default.
- W2160171594 cites W2059958205 @default.
- W2160171594 cites W2062122187 @default.
- W2160171594 cites W2064740570 @default.
- W2160171594 cites W2069147852 @default.
- W2160171594 cites W2072137391 @default.
- W2160171594 cites W2073692301 @default.
- W2160171594 cites W2074469498 @default.
- W2160171594 cites W2075332563 @default.
- W2160171594 cites W2075733574 @default.
- W2160171594 cites W2076194741 @default.
- W2160171594 cites W2081432712 @default.
- W2160171594 cites W2088516219 @default.
- W2160171594 cites W2089370460 @default.
- W2160171594 cites W2089542655 @default.
- W2160171594 cites W2089804431 @default.
- W2160171594 cites W2090559362 @default.
- W2160171594 cites W2094524182 @default.
- W2160171594 cites W2095466199 @default.
- W2160171594 cites W2096523159 @default.
- W2160171594 cites W2097089862 @default.
- W2160171594 cites W2098276344 @default.
- W2160171594 cites W2098499757 @default.
- W2160171594 cites W2098949852 @default.
- W2160171594 cites W2100945326 @default.