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- W2160188894 abstract "A method by combination of centrifugal ultrafiltration (CUF) sampling with liquid chromatography−mass spectrometry (LC−MS) analysis was established to evaluate the DNA structure and sequence selectivity of the multiple compounds in a small molecule library. The developed method was applied to analyze the extracts of natural products Coptis chinensis Franch and Rheum palmatum (L.). From the obtained biological fingerprinting chromatograms, 7 compounds in C. chinensis Franch and 11 in R. palmatum (L.) were screened out as DNA binding agents. Most of these compounds were identified by standards and LC−MS analysis after the sample pretreatment with the DNA immobilized cartridge. DNA structural binding preference of the multiple active compounds in these two extracts was then evaluated simultaneously without purification." @default.
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- W2160188894 date "2006-06-09" @default.
- W2160188894 modified "2023-10-18" @default.
- W2160188894 title "Biological Fingerprinting Analysis by Liquid Chromatography/Mass Spectrometry for Evaluation of DNA Structural Selectivity of Multiple Compounds in Natural Products" @default.
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- W2160188894 doi "https://doi.org/10.1021/cc060039l" @default.
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