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- W2160199503 abstract "Abstract The purpose of this study was to determine the plasma pharmacokinetics ( PK ) and toxicity of zebularine, an oral cytidine analog with demethylating activity, in dogs. Plasma zebularine concentrations were determined by HPLC‐MS / MS following an oral zebularine dose of 8 or 4 mg kg −1 . Plasma zebularine clearance was constant. M ean maximum concentration (C max ) was 23 ± 4.8 and 8.6 ± 1.4 µM following 8 and 4 mg kg −1 , respectively. Mean half‐life was 5.7 ± 0.84 and 7.1 ± 2.1 following 8 and 4 mg kg −1 , respectively. A single 8 mg kg −1 dose was well tolerated. Daily 4 mg kg −1 treatment in three laboratory dogs resulted in grade 4 neutropenia ( n = 3), grade 1 anorexia ( n = 2) and grade 1 or 2 dermatologic changes ( n = 2). All adverse events resolved with supportive care. A 4 mg kg −1 dose every 21 days was well tolerated. A follow‐up dose escalation study is in progress with a lower starting dose." @default.
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- W2160199503 date "2015-07-14" @default.
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- W2160199503 title "Pharmacokinetics and toxicity of the novel oral demethylating agent zebularine in laboratory and tumor bearing dogs" @default.
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- W2160199503 doi "https://doi.org/10.1111/vco.12159" @default.
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