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• W2160200114 abstract "Research into the origins of introns is at a critical juncture in the resolution of theories on the evolution of early life (which came first, RNA or DNA?), the identity of LUCA (the last universal common ancestor, was it prokaryotic- or eukaryotic-like?), and the significance of noncoding nucleotide variation. One early notion was that introns would have evolved as a component of an efficient mechanism for the origin of genes. But alternative theories emerged as well. From the debate between the introns-early and introns-late theories came the proposal that introns arose before the origin of genetically encoded proteins and DNA, and the more recent introns-first theory, which postulates the presence of introns at that early evolutionary stage from a reconstruction of the RNA world. Here we review seminal and recent ideas about intron origins. Recent discoveries about the patterns and causes of intron evolution make this one of the most hotly debated and exciting topics in molecular evolutionary biology today." @default.
• W2160200114 created "2016-06-24" @default.
• W2160200114 creator A5006265708 @default.
• W2160200114 creator A5024373014 @default.
• W2160200114 creator A5031885027 @default.
• W2160200114 date "2006-12-01" @default.
• W2160200114 modified "2023-10-18" @default.
• W2160200114 title "Origins and Evolution of Spliceosomal Introns" @default.
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