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• W2160225590 abstract "To further enhance anticancer effect of Shepherdin and overcome limitation of peptide therapy, recombinant adeno-associated virus (rAAV) was constructed with following strategies: therapeutic peptide secretory expression and adeno-associated virus gene transfer system. MTT assay and flow cytometric analysis revealed that rAAV harboring fusion gene NT4-Ant-Shepherdin significantly suppressed A549 cell growth in a time-dependent manner and induced apoptosis. In the infected A549 cells, survivin expression level decreased strongly while Caspase-3/7 activities increased significantly. These results indicated that rAAV harboring fusion gene NT4-Ant-Shepherdin may be a novel strategy in lung cancer peptide therapy." @default.
• W2160225590 created "2016-06-24" @default.
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• W2160225590 date "2009-12-07" @default.
• W2160225590 modified "2023-10-16" @default.
• W2160225590 title "Adeno-Associated Virus Harboring Fusion Gene NT4-Ant-Shepherdin Induce Cell Death in Human Lung Cancer Cells" @default.
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• W2160225590 doi "https://doi.org/10.3109/07357900903095706" @default.
• W2160225590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19968500" @default.
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