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- W2160242565 endingPage "685" @default.
- W2160242565 startingPage "685" @default.
- W2160242565 abstract "Gap junction hemichannels and cell–cell channels have roles in coordinating numerous cellular processes, due to their permeability to extra and intracellular signaling molecules. Another mechanism of cellular coordination is provided by a vast array of growth factors that interact with relatively selective cell membrane receptors. These receptors can affect cellular transduction pathways, including alteration of intracellular concentration of free Ca2+ and free radicals and activation of protein kinases or phosphatases. Connexin and pannexin based channels constitute recently described targets of growth factor signal transduction pathways, but little is known regarding the effects of growth factor signaling on pannexin based channels. The effects of growth factors on these two channel types seem to depend on the cell type, cell stage and connexin and pannexin isoform expressed. The functional state of hemichannels and gap junction channels are affected in opposite directions by FGF-1 viaprotein kinase-dependent mechanisms. These changes are largely explained by channels insertion in or withdrawal from the cell membrane, but changes in open probability might also occur due to changes in phosphorylation and redox state of channel subunits. The functional consequence of variation in cell–cell communicationvia these membrane channels is implicated in disease as well as normal cellular responses." @default.
- W2160242565 created "2016-06-24" @default.
- W2160242565 creator A5005053813 @default.
- W2160242565 creator A5009773603 @default.
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- W2160242565 creator A5078786344 @default.
- W2160242565 creator A5083887530 @default.
- W2160242565 date "2012-01-01" @default.
- W2160242565 modified "2023-10-18" @default.
- W2160242565 title "Modulation of gap junction channels and hemichannels by growth factors" @default.
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