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- W2160255518 abstract "Hepatocellular carcinoma (HCC) remains one of the most prevalent malignant diseases worldwide, and the majority of cases are related to hepatitis B virus (HBV) infection. Interactions between the HBV-encoded X (HBx) protein and host factors are known to play major roles in the onset and progression of HBV-related HCC. These dynamic molecular mechanisms are extremely complex and lead to prominent changes in the host genetic and epigenetic architecture. This review summarizes the current knowledge about HBx-induced epigenetic changes, including aberrations in DNA methylation, histone modifications, and microRNA expression, and their roles in HBV-infected liver cells and HBV-related HCC. Moreover, the HBx-mediated epigenetic control of HBV covalently closed circular DNA (cccDNA) is also discussed. Although this field of study is relatively new, the accumulated evidence has indicated that the epigenetic events induced by HBx play important roles in the development of HBV-related HCC. Ongoing research will help to identify practical applications of the HBV-related epigenetic signatures as biomarkers for early HCC detection or as potential targets to prevent and treat HBV-related HCC." @default.
- W2160255518 created "2016-06-24" @default.
- W2160255518 creator A5038332399 @default.
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- W2160255518 creator A5057409749 @default.
- W2160255518 creator A5067915781 @default.
- W2160255518 creator A5087081408 @default.
- W2160255518 date "2013-08-01" @default.
- W2160255518 modified "2023-10-16" @default.
- W2160255518 title "Hepatitis B Virus X Protein-Induced Aberrant Epigenetic Modifications Contributing to Human Hepatocellular Carcinoma Pathogenesis" @default.
- W2160255518 cites W1515703466 @default.
- W2160255518 cites W1525178335 @default.
- W2160255518 cites W1651425720 @default.
- W2160255518 cites W1667463872 @default.
- W2160255518 cites W1676377504 @default.
- W2160255518 cites W1900657670 @default.
- W2160255518 cites W1971281277 @default.
- W2160255518 cites W1975227141 @default.
- W2160255518 cites W1976118924 @default.
- W2160255518 cites W1984807040 @default.
- W2160255518 cites W1985022589 @default.
- W2160255518 cites W1985563243 @default.
- W2160255518 cites W1986533953 @default.
- W2160255518 cites W1988981936 @default.
- W2160255518 cites W1989312510 @default.
- W2160255518 cites W1994242106 @default.
- W2160255518 cites W1995958786 @default.
- W2160255518 cites W1998149374 @default.
- W2160255518 cites W1998284663 @default.
- W2160255518 cites W2001253649 @default.
- W2160255518 cites W2001891149 @default.
- W2160255518 cites W2005784985 @default.
- W2160255518 cites W2008913148 @default.
- W2160255518 cites W2011369409 @default.
- W2160255518 cites W2017240003 @default.
- W2160255518 cites W2017325634 @default.
- W2160255518 cites W2017341383 @default.
- W2160255518 cites W2021584389 @default.
- W2160255518 cites W2027884555 @default.
- W2160255518 cites W2031562284 @default.
- W2160255518 cites W2035216589 @default.
- W2160255518 cites W2035920453 @default.
- W2160255518 cites W2040257851 @default.
- W2160255518 cites W2040996073 @default.
- W2160255518 cites W2043861742 @default.
- W2160255518 cites W2046980861 @default.
- W2160255518 cites W2048139253 @default.
- W2160255518 cites W2048280970 @default.
- W2160255518 cites W2049059847 @default.
- W2160255518 cites W2051310238 @default.
- W2160255518 cites W2053900270 @default.
- W2160255518 cites W2056768380 @default.
- W2160255518 cites W2057708151 @default.
- W2160255518 cites W2057872902 @default.
- W2160255518 cites W2058264480 @default.
- W2160255518 cites W2065284473 @default.
- W2160255518 cites W2069009920 @default.
- W2160255518 cites W2070235586 @default.
- W2160255518 cites W2070439779 @default.
- W2160255518 cites W2072497467 @default.
- W2160255518 cites W2073362784 @default.
- W2160255518 cites W2073580257 @default.
- W2160255518 cites W2076983714 @default.
- W2160255518 cites W2078515067 @default.
- W2160255518 cites W2078828237 @default.
- W2160255518 cites W2081199546 @default.
- W2160255518 cites W2081472291 @default.
- W2160255518 cites W2083430194 @default.
- W2160255518 cites W2087732778 @default.
- W2160255518 cites W2092293354 @default.
- W2160255518 cites W2093019351 @default.
- W2160255518 cites W2096083625 @default.
- W2160255518 cites W2110486307 @default.
- W2160255518 cites W2111689605 @default.
- W2160255518 cites W2114973741 @default.
- W2160255518 cites W2117683028 @default.
- W2160255518 cites W2123793343 @default.
- W2160255518 cites W2130516508 @default.
- W2160255518 cites W2133037087 @default.
- W2160255518 cites W2133452708 @default.
- W2160255518 cites W2135231304 @default.
- W2160255518 cites W2146634563 @default.
- W2160255518 cites W2151497179 @default.
- W2160255518 cites W2158998217 @default.
- W2160255518 cites W2162167592 @default.
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- W2160255518 doi "https://doi.org/10.1128/mcb.00205-13" @default.
- W2160255518 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3719687" @default.
- W2160255518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23716588" @default.
- W2160255518 hasPublicationYear "2013" @default.
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