FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160257510> ?p ?o ?g. }

• W2160257510 endingPage "349" @default.
• W2160257510 startingPage "340" @default.
• W2160257510 abstract "The genomes of Trypanosoma brucei, Leishmania major and Trypanosoma cruzi each encode 10 proteins with PUF domains. PUF domain proteins from yeast and metazoa have been shown to bind RNA and to regulate mRNA stability and translation. Phylogenetic analysis suggested that the PUF proteins were duplicated and diverged early in evolution, and that most PUF proteins were lost during the evolution of mammals. Depletion of any of the first nine T. brucei PUF protein mRNAs by RNA interference had no effect on cell growth; combined depletion of PUF1 and PUF3, PUF3 and PUF4, and PUF1 and PUF4 mRNAs also had no effect. In conflict with a previous report, procyclic trypanosomes lacking PUF1 genes grew normally and we could find no evidence that PUF1 is required for growth of trypanosomes in culture. Depletion or elimination of PUF1 mRNA did not affect the abundances of any other mRNAs, as detected in microarray analysis, and also had minimal effects on the proteome. (In control experiments, treatment of bloodstream and procyclic cells with 100 ng/ml tetracycline also had no detectable effects on the transcriptome and proteome.) PUF1 preferentially bound to retroposon RNAs and was not associated with polysomes. We suggest that, as in yeast, there may be functional redundancy among the Kinetoplastid PUF proteins, or they may be involved in fine-tuning gene expression together with other proteins. Alternatively, PUF proteins may be needed in differentiating trypanosomes or in non-culturable life-cycle stages." @default.
• W2160257510 created "2016-06-24" @default.
• W2160257510 creator A5017815858 @default.
• W2160257510 creator A5018588442 @default.
• W2160257510 creator A5042050811 @default.
• W2160257510 creator A5062218408 @default.
• W2160257510 creator A5073477304 @default.
• W2160257510 creator A5082358386 @default.
• W2160257510 date "2006-12-01" @default.
• W2160257510 modified "2023-10-16" @default.
• W2160257510 title "Functional analysis of Trypanosoma brucei PUF1" @default.
• W2160257510 cites W1542686183 @default.
• W2160257510 cites W1575542444 @default.
• W2160257510 cites W1974948854 @default.
• W2160257510 cites W1978625135 @default.
• W2160257510 cites W1979521848 @default.
• W2160257510 cites W1982512914 @default.
• W2160257510 cites W1984633201 @default.
• W2160257510 cites W1994731553 @default.
• W2160257510 cites W1994844474 @default.
• W2160257510 cites W2042104697 @default.
• W2160257510 cites W2042392327 @default.
• W2160257510 cites W2043407551 @default.
• W2160257510 cites W2043839995 @default.
• W2160257510 cites W2049402769 @default.
• W2160257510 cites W2070077900 @default.
• W2160257510 cites W2086964845 @default.
• W2160257510 cites W2093822146 @default.
• W2160257510 cites W2094525292 @default.
• W2160257510 cites W2096052736 @default.
• W2160257510 cites W2104482284 @default.
• W2160257510 cites W2110980933 @default.
• W2160257510 cites W2111565312 @default.
• W2160257510 cites W2116820077 @default.
• W2160257510 cites W2129984117 @default.
• W2160257510 cites W2131361841 @default.
• W2160257510 cites W2149676146 @default.
• W2160257510 cites W2156299709 @default.
• W2160257510 cites W2163138210 @default.
• W2160257510 cites W2163314056 @default.
• W2160257510 cites W2165536015 @default.
• W2160257510 cites W2169300762 @default.
• W2160257510 cites W2171252114 @default.
• W2160257510 cites W2181464620 @default.
• W2160257510 cites W2394625668 @default.
• W2160257510 doi "https://doi.org/10.1016/j.molbiopara.2006.09.007" @default.
• W2160257510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17052765" @default.
• W2160257510 hasPublicationYear "2006" @default.
• W2160257510 type Work @default.
• W2160257510 sameAs 2160257510 @default.
• W2160257510 citedByCount "43" @default.
• W2160257510 countsByYear W21602575102012 @default.
• W2160257510 countsByYear W21602575102013 @default.
• W2160257510 countsByYear W21602575102014 @default.
• W2160257510 countsByYear W21602575102015 @default.
• W2160257510 countsByYear W21602575102016 @default.
• W2160257510 countsByYear W21602575102017 @default.
• W2160257510 countsByYear W21602575102018 @default.
• W2160257510 countsByYear W21602575102019 @default.
• W2160257510 countsByYear W21602575102020 @default.
• W2160257510 countsByYear W21602575102021 @default.
• W2160257510 crossrefType "journal-article" @default.
• W2160257510 hasAuthorship W2160257510A5017815858 @default.
• W2160257510 hasAuthorship W2160257510A5018588442 @default.
• W2160257510 hasAuthorship W2160257510A5042050811 @default.
• W2160257510 hasAuthorship W2160257510A5062218408 @default.
• W2160257510 hasAuthorship W2160257510A5073477304 @default.
• W2160257510 hasAuthorship W2160257510A5082358386 @default.
• W2160257510 hasBestOaLocation W21602575102 @default.
• W2160257510 hasConcept C104317684 @default.
• W2160257510 hasConcept C104397665 @default.
• W2160257510 hasConcept C105580179 @default.
• W2160257510 hasConcept C10879258 @default.
• W2160257510 hasConcept C149364088 @default.
• W2160257510 hasConcept C150194340 @default.
• W2160257510 hasConcept C162317418 @default.
• W2160257510 hasConcept C2779502636 @default.
• W2160257510 hasConcept C41282012 @default.
• W2160257510 hasConcept C54355233 @default.
• W2160257510 hasConcept C65666806 @default.
• W2160257510 hasConcept C67705224 @default.
• W2160257510 hasConcept C86803240 @default.
• W2160257510 hasConcept C88478588 @default.
• W2160257510 hasConcept C95444343 @default.
• W2160257510 hasConceptScore W2160257510C104317684 @default.
• W2160257510 hasConceptScore W2160257510C104397665 @default.
• W2160257510 hasConceptScore W2160257510C105580179 @default.
• W2160257510 hasConceptScore W2160257510C10879258 @default.
• W2160257510 hasConceptScore W2160257510C149364088 @default.
• W2160257510 hasConceptScore W2160257510C150194340 @default.
• W2160257510 hasConceptScore W2160257510C162317418 @default.
• W2160257510 hasConceptScore W2160257510C2779502636 @default.
• W2160257510 hasConceptScore W2160257510C41282012 @default.
• W2160257510 hasConceptScore W2160257510C54355233 @default.
• W2160257510 hasConceptScore W2160257510C65666806 @default.
• W2160257510 hasConceptScore W2160257510C67705224 @default.
• W2160257510 hasConceptScore W2160257510C86803240 @default.
• W2160257510 hasConceptScore W2160257510C88478588 @default.

• next