FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160263651> ?p ?o ?g. }

• W2160263651 endingPage "417" @default.
• W2160263651 startingPage "410" @default.
• W2160263651 abstract "Ecklonia cava (EC) is a brown alga that has demonstrated radical scavenging, bactericidal, tyrosinase inhibitory, and protease inhibitory activities. However, the molecular mechanisms underlying its anti-inflammatory action remain unclear. In the current study, we attempted to determine whether pretreatment with EC induces a significant inhibition of anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated murine BV2 microglia. Our results indicate that EC inhibits LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in a concentration-dependent manner and inhibits inducible nitric oxide (iNOS) and cyclooxygenase (COX)-2 in BV2 microglia without significant cytotoxicity. EC treatment significantly reduced nuclear factor-κB (NF-κB) translocation and DNA-binding in LPS-stimulated BV2 microglia. This effect was mediated through the inhibition of the degradation of the inhibitor κB and by inhibition of the mitogen-activated protein kinase (MAPK) phosphorylation, at least in part by inhibiting the generation of reactive oxygen species. Our data also indicate that EC extracts exert anti-inflammatory effects by suppressing proinflammatory cytokines. Collectively, these results suggest that EC suppresses the induction of cytokines by LPS, as well as iNOS and COX-2 expression, by blocking NF-κB and MAPK activation. These findings provide mechanistic insights into the anti-inflammatory and neuroprotective actions of EC in BV2 microglia." @default.
• W2160263651 created "2016-06-24" @default.
• W2160263651 creator A5001967366 @default.
• W2160263651 creator A5002188804 @default.
• W2160263651 creator A5009518900 @default.
• W2160263651 creator A5018421576 @default.
• W2160263651 creator A5037284987 @default.
• W2160263651 creator A5055533358 @default.
• W2160263651 creator A5057841119 @default.
• W2160263651 creator A5061511587 @default.
• W2160263651 creator A5069292897 @default.
• W2160263651 creator A5071257269 @default.
• W2160263651 creator A5080001926 @default.
• W2160263651 date "2009-02-01" @default.
• W2160263651 modified "2023-10-03" @default.
• W2160263651 title "Ecklonia cava ethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in BV2 microglia via the MAP kinase and NF-κB pathways" @default.
• W2160263651 cites W1586509612 @default.
• W2160263651 cites W1874568289 @default.
• W2160263651 cites W1967291007 @default.
• W2160263651 cites W1976745697 @default.
• W2160263651 cites W1988659689 @default.
• W2160263651 cites W1991763618 @default.
• W2160263651 cites W1991805788 @default.
• W2160263651 cites W1999807247 @default.
• W2160263651 cites W2003437276 @default.
• W2160263651 cites W2007087158 @default.
• W2160263651 cites W2018831724 @default.
• W2160263651 cites W2025392129 @default.
• W2160263651 cites W2028885228 @default.
• W2160263651 cites W2033079614 @default.
• W2160263651 cites W2035335881 @default.
• W2160263651 cites W2036542628 @default.
• W2160263651 cites W2039326711 @default.
• W2160263651 cites W2039453997 @default.
• W2160263651 cites W2046970075 @default.
• W2160263651 cites W2049460970 @default.
• W2160263651 cites W2049742063 @default.
• W2160263651 cites W2053180614 @default.
• W2160263651 cites W2054046949 @default.
• W2160263651 cites W2054644657 @default.
• W2160263651 cites W2066569577 @default.
• W2160263651 cites W2070046033 @default.
• W2160263651 cites W2071695496 @default.
• W2160263651 cites W2072793831 @default.
• W2160263651 cites W2076339827 @default.
• W2160263651 cites W2077603092 @default.
• W2160263651 cites W2081695783 @default.
• W2160263651 cites W2081815828 @default.
• W2160263651 cites W2084928287 @default.
• W2160263651 cites W2090703365 @default.
• W2160263651 cites W2093019685 @default.
• W2160263651 cites W2109342780 @default.
• W2160263651 cites W2115350007 @default.
• W2160263651 cites W2117227343 @default.
• W2160263651 cites W2128764055 @default.
• W2160263651 cites W2139272067 @default.
• W2160263651 cites W2147830608 @default.
• W2160263651 cites W2149200346 @default.
• W2160263651 cites W2151892297 @default.
• W2160263651 cites W2154975058 @default.
• W2160263651 cites W2158094166 @default.
• W2160263651 cites W2158686638 @default.
• W2160263651 cites W2166781237 @default.
• W2160263651 cites W2168110247 @default.
• W2160263651 cites W2189177921 @default.
• W2160263651 doi "https://doi.org/10.1016/j.fct.2008.11.041" @default.
• W2160263651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19111593" @default.
• W2160263651 hasPublicationYear "2009" @default.
• W2160263651 type Work @default.
• W2160263651 sameAs 2160263651 @default.
• W2160263651 citedByCount "99" @default.
• W2160263651 countsByYear W21602636512012 @default.
• W2160263651 countsByYear W21602636512013 @default.
• W2160263651 countsByYear W21602636512014 @default.
• W2160263651 countsByYear W21602636512015 @default.
• W2160263651 countsByYear W21602636512016 @default.
• W2160263651 countsByYear W21602636512017 @default.
• W2160263651 countsByYear W21602636512018 @default.
• W2160263651 countsByYear W21602636512019 @default.
• W2160263651 countsByYear W21602636512020 @default.
• W2160263651 countsByYear W21602636512021 @default.
• W2160263651 countsByYear W21602636512022 @default.
• W2160263651 countsByYear W21602636512023 @default.
• W2160263651 crossrefType "journal-article" @default.
• W2160263651 hasAuthorship W2160263651A5001967366 @default.
• W2160263651 hasAuthorship W2160263651A5002188804 @default.
• W2160263651 hasAuthorship W2160263651A5009518900 @default.
• W2160263651 hasAuthorship W2160263651A5018421576 @default.
• W2160263651 hasAuthorship W2160263651A5037284987 @default.
• W2160263651 hasAuthorship W2160263651A5055533358 @default.
• W2160263651 hasAuthorship W2160263651A5057841119 @default.
• W2160263651 hasAuthorship W2160263651A5061511587 @default.
• W2160263651 hasAuthorship W2160263651A5069292897 @default.
• W2160263651 hasAuthorship W2160263651A5071257269 @default.
• W2160263651 hasAuthorship W2160263651A5080001926 @default.
• W2160263651 hasConcept C164027704 @default.
• W2160263651 hasConcept C178790620 @default.
• W2160263651 hasConcept C181199279 @default.

• next