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• W2160282023 abstract "Unintegrated human immunodeficiency virus (HIV) DNA are viral DNA products formed naturally during HIV replication. While the integrated proviral DNA form is transcriptionally active and results in productive infection, unintegrated DNA is also capable of expression of viral RNA and proteins. Previously, we showed that HIV Vpr enhances expression from integrase-defective HIV. Here we show that Vpr activation of expression is partially dependent upon the presence of a transcriptionally active HIV promoter and results in increased transcription of unspliced gag and spliced nef viral RNA. While Tat is detectable during infection with integrase-defective HIV, Tat levels are not affected by the presence of Vpr. Mutation studies reveal that Tat is dispensable for the Vpr-mediated enhancement of expression from unintegrated DNA. We find that virion-associated Vpr is sufficient for Nef expression from unintegrated viral DNA, resulting in the efficient downregulation of CD4 from the surface of infected cells. These results provide a mechanism by which Nef expression from unintegrated HIV type 1 DNA expression occurs." @default.
• W2160282023 created "2016-06-24" @default.
• W2160282023 creator A5027177196 @default.
• W2160282023 creator A5048646352 @default.
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• W2160282023 date "2007-10-01" @default.
• W2160282023 modified "2023-10-17" @default.
• W2160282023 title "Vpr Is Required for Efficient Nef Expression from Unintegrated Human Immunodeficiency Virus Type 1 DNA" @default.
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• W2160282023 doi "https://doi.org/10.1128/jvi.00947-07" @default.
• W2160282023 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2045493" @default.
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