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- W2160288264 abstract "1 The cardiotonic agent DPI 201-106 (4-[3-(4-diphenylmethyl-1-piperazinyl-2-hydroxypropyl]-1H- indole-2-carbonitrile) which modifies the sarcolemmal Na+ channel gating system and has electrophysiological properties of class III antiarrhythmics was investigated for local anaesthetic and antiarrhythmic activity. 2 The compound action potential amplitude of cat cervical vagus nerves in vitro was decreased by DPI 201-106 in a concentration-dependent manner, the IC50 being 1.82 × 10−5 M. This was paralleled by a slowing in conduction velocity and demonstrates local anaesthetic effects. 3 Ventricular fibrillation which occurs in response to coronary artery reperfusion in rats was prevented by intravenous infusions of 0.3 mg kg−1 min−1 of DPI 201-106. 4 The arrhythmogenic intravenous doses of aconitine in rats were increased following pretreatment with DPI 201-106 in a dose-dependent manner. 5 DPI 201-106 did not protect against ouabain-induced arrhythmias in guinea-pigs. 6 The results demonstrate that DPI 201-106 has local anaesthetic effects and is a potential antiarrhythmic." @default.
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- W2160288264 date "1986-10-01" @default.
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- W2160288264 title "Antiarrhythmic effects of DPI 201-106" @default.
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- W2160288264 doi "https://doi.org/10.1111/j.1476-5381.1986.tb10258.x" @default.
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