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- W2160304884 abstract "The full complement of oocytes as primordial follicles is established during fetal life. These primordial follicles can remain viable in humans for more than 50 yr, although damage to the oocyte occurs at an increased frequency with age, even in short-lived species, such as mice. A still unresolved question is how the pool of primordial follicles remains quiescent, and what triggers the activation of the oocyte and follicle to develop. The study in mice by Mora et al. [1] in this issue of Biology of Reproduction has addressed the immediate downstream effects of follicle activation by analyzing the changes that occur in intercellular junctions and associated proteins during the transition from flattened to cuboidal granulosa cells after initiation of follicle growth. The authors report a number of novel observations, principal among which is that these activated granulosa cells express proteins and junctions that are akin to mesenchymal rather than epithelial cells, suggesting that the granulosa cells undergo a partial epithelial-to-mesenchymal transition (EMT) as they activate and develop, despite the" @default.
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- W2160304884 date "2012-05-01" @default.
- W2160304884 modified "2023-09-27" @default.
- W2160304884 title "Epithelial-to-Mesenchymal Transition in Granulosa Cells: A Key to Activation of Follicle Growth?" @default.
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- W2160304884 doi "https://doi.org/10.1095/biolreprod.112.100156" @default.
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