FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160331251> ?p ?o ?g. }

• W2160331251 endingPage "2695" @default.
• W2160331251 startingPage "2686" @default.
• W2160331251 abstract "Background— Obesity is a risk factor for cardiovascular disease and is strongly associated with insulin resistance and type 2 diabetes. Recent studies in obese humans and animals demonstrated increased myocardial oxygen consumption (MV̇ o 2 ) and reduced cardiac efficiency (CE); however, the underlying mechanisms remain unclear. The present study was performed to determine whether mitochondrial dysfunction and uncoupling are responsible for reduced cardiac performance and efficiency in ob/ob mice. Methods and Results— Cardiac function, MV̇ o 2 , mitochondrial respiration, and ATP synthesis were measured in 9-week-old ob/ob and control mouse hearts. Contractile function and MV̇ o 2 in glucose-perfused ob/ob hearts were similar to controls under basal conditions but were reduced under high workload. Perfusion of ob/ob hearts with glucose and palmitate increased MV̇ o 2 and reduced CE by 23% under basal conditions, and CE remained impaired at high workload. In glucose-perfused ob/ob hearts, mitochondrial state 3 respirations were reduced but ATP/O ratios were unchanged. In contrast, state 3 respiration rates were similar in ob/ob and control mitochondria from hearts perfused with palmitate and glucose, but ATP synthesis rates and ATP/O ratios were significantly reduced in ob/ob , which suggests increased mitochondrial uncoupling. Pyruvate dehydrogenase activity and protein levels of complexes I, III, and V were reduced in obese mice. Conclusions— These data indicate that reduced mitochondrial oxidative capacity may contribute to cardiac dysfunction in ob/ob mice. Moreover, fatty acid but not glucose-induced mitochondrial uncoupling reduces CE in obese mice by limiting ATP production and increasing MV̇ o 2 ." @default.
• W2160331251 created "2016-06-24" @default.
• W2160331251 creator A5001920865 @default.
• W2160331251 creator A5022164343 @default.
• W2160331251 creator A5039093871 @default.
• W2160331251 creator A5042373014 @default.
• W2160331251 creator A5063731996 @default.
• W2160331251 creator A5069855582 @default.
• W2160331251 date "2005-10-25" @default.
• W2160331251 modified "2023-10-01" @default.
• W2160331251 title "Reduced Mitochondrial Oxidative Capacity and Increased Mitochondrial Uncoupling Impair Myocardial Energetics in Obesity" @default.
• W2160331251 cites W1919789442 @default.
• W2160331251 cites W1971303004 @default.
• W2160331251 cites W1983359412 @default.
• W2160331251 cites W1986399270 @default.
• W2160331251 cites W1999391010 @default.
• W2160331251 cites W2006205217 @default.
• W2160331251 cites W2012898950 @default.
• W2160331251 cites W2025664849 @default.
• W2160331251 cites W2036573181 @default.
• W2160331251 cites W2041618682 @default.
• W2160331251 cites W2055244328 @default.
• W2160331251 cites W2059844165 @default.
• W2160331251 cites W2077961548 @default.
• W2160331251 cites W2090895117 @default.
• W2160331251 cites W2096474548 @default.
• W2160331251 cites W2098612318 @default.
• W2160331251 cites W2106411160 @default.
• W2160331251 cites W2106755489 @default.
• W2160331251 cites W2113362144 @default.
• W2160331251 cites W2114215010 @default.
• W2160331251 cites W2122167119 @default.
• W2160331251 cites W2126975783 @default.
• W2160331251 cites W2128569391 @default.
• W2160331251 cites W2144766505 @default.
• W2160331251 cites W2155538197 @default.
• W2160331251 cites W2155799150 @default.
• W2160331251 cites W2156172044 @default.
• W2160331251 cites W2165961251 @default.
• W2160331251 cites W2313589149 @default.
• W2160331251 cites W4254261652 @default.
• W2160331251 doi "https://doi.org/10.1161/circulationaha.105.554360" @default.
• W2160331251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16246967" @default.
• W2160331251 hasPublicationYear "2005" @default.
• W2160331251 type Work @default.
• W2160331251 sameAs 2160331251 @default.
• W2160331251 citedByCount "440" @default.
• W2160331251 countsByYear W21603312512012 @default.
• W2160331251 countsByYear W21603312512013 @default.
• W2160331251 countsByYear W21603312512014 @default.
• W2160331251 countsByYear W21603312512015 @default.
• W2160331251 countsByYear W21603312512016 @default.
• W2160331251 countsByYear W21603312512017 @default.
• W2160331251 countsByYear W21603312512018 @default.
• W2160331251 countsByYear W21603312512019 @default.
• W2160331251 countsByYear W21603312512020 @default.
• W2160331251 countsByYear W21603312512021 @default.
• W2160331251 countsByYear W21603312512022 @default.
• W2160331251 countsByYear W21603312512023 @default.
• W2160331251 crossrefType "journal-article" @default.
• W2160331251 hasAuthorship W2160331251A5001920865 @default.
• W2160331251 hasAuthorship W2160331251A5022164343 @default.
• W2160331251 hasAuthorship W2160331251A5039093871 @default.
• W2160331251 hasAuthorship W2160331251A5042373014 @default.
• W2160331251 hasAuthorship W2160331251A5063731996 @default.
• W2160331251 hasAuthorship W2160331251A5069855582 @default.
• W2160331251 hasConcept C111566952 @default.
• W2160331251 hasConcept C126322002 @default.
• W2160331251 hasConcept C134018914 @default.
• W2160331251 hasConcept C146957229 @default.
• W2160331251 hasConcept C2778024521 @default.
• W2160331251 hasConcept C2778198053 @default.
• W2160331251 hasConcept C2779306644 @default.
• W2160331251 hasConcept C2779406938 @default.
• W2160331251 hasConcept C2780642333 @default.
• W2160331251 hasConcept C28859421 @default.
• W2160331251 hasConcept C511355011 @default.
• W2160331251 hasConcept C55493867 @default.
• W2160331251 hasConcept C57600042 @default.
• W2160331251 hasConcept C71924100 @default.
• W2160331251 hasConcept C82736064 @default.
• W2160331251 hasConcept C86803240 @default.
• W2160331251 hasConceptScore W2160331251C111566952 @default.
• W2160331251 hasConceptScore W2160331251C126322002 @default.
• W2160331251 hasConceptScore W2160331251C134018914 @default.
• W2160331251 hasConceptScore W2160331251C146957229 @default.
• W2160331251 hasConceptScore W2160331251C2778024521 @default.
• W2160331251 hasConceptScore W2160331251C2778198053 @default.
• W2160331251 hasConceptScore W2160331251C2779306644 @default.
• W2160331251 hasConceptScore W2160331251C2779406938 @default.
• W2160331251 hasConceptScore W2160331251C2780642333 @default.
• W2160331251 hasConceptScore W2160331251C28859421 @default.
• W2160331251 hasConceptScore W2160331251C511355011 @default.
• W2160331251 hasConceptScore W2160331251C55493867 @default.
• W2160331251 hasConceptScore W2160331251C57600042 @default.
• W2160331251 hasConceptScore W2160331251C71924100 @default.
• W2160331251 hasConceptScore W2160331251C82736064 @default.
• W2160331251 hasConceptScore W2160331251C86803240 @default.

• next