FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160344881> ?p ?o ?g. }

• W2160344881 endingPage "3076" @default.
• W2160344881 startingPage "3064" @default.
• W2160344881 abstract "Respiratory complexes are encoded by two genomes (mitochondrial DNA [mtDNA] and nuclear DNA [nDNA]). Although the importance of intergenomic coadaptation is acknowledged, the forces and constraints shaping such coevolution are largely unknown. Previous works using cytochrome c oxidase (COX) as a model enzyme have led to the so-called optimizing interaction hypothesis. According to this view, mtDNA-encoded residues close to nDNA-encoded residues evolve faster than the rest of positions, favoring the optimization of protein-protein interfaces. Herein, using evolutionary data in combination with structural information of COX, we show that failing to discern the effects of interaction from other structural and functional effects can lead to deceptive conclusions such as the optimizing hypothesis. Once spurious factors have been accounted for, data analysis shows that mtDNA-encoded residues engaged in contacts are, in general, more constrained than their noncontact counterparts. Nevertheless, noncontact residues from the surface of COX I subunit are a remarkable exception, being subjected to an exceptionally high purifying selection that may be related to the maintenance of a suitable heme environment. We also report that mtDNA-encoded residues involved in contacts with other mtDNA-encoded subunits are more constrained than mtDNA-encoded residues interacting with nDNA-encoded polypeptides. This differential behavior cannot be explained on the basis of predicted thermodynamic stability, as interactions between mtDNA-encoded subunits contribute more weakly to the complex stability than those interactions between subunits encoded by different genomes. Therefore, the higher conservation observed among mtDNA-encoded residues involved in intragenome interactions is likely due to factors other than structural stability." @default.
• W2160344881 created "2016-06-24" @default.
• W2160344881 creator A5013829079 @default.
• W2160344881 creator A5020998052 @default.
• W2160344881 creator A5021061692 @default.
• W2160344881 creator A5052171878 @default.
• W2160344881 creator A5061741483 @default.
• W2160344881 date "2014-10-29" @default.
• W2160344881 modified "2023-10-16" @default.
• W2160344881 title "Protein–Protein Interfaces from Cytochrome c Oxidase I Evolve Faster than Nonbinding Surfaces, yet Negative Selection Is the Driving Force" @default.
• W2160344881 cites W13095824 @default.
• W2160344881 cites W1534916047 @default.
• W2160344881 cites W1541314725 @default.
• W2160344881 cites W1555986815 @default.
• W2160344881 cites W1966417047 @default.
• W2160344881 cites W1967590676 @default.
• W2160344881 cites W1970132737 @default.
• W2160344881 cites W1977748495 @default.
• W2160344881 cites W1986248905 @default.
• W2160344881 cites W2003646121 @default.
• W2160344881 cites W2023490488 @default.
• W2160344881 cites W2031972450 @default.
• W2160344881 cites W2037900992 @default.
• W2160344881 cites W2044851125 @default.
• W2160344881 cites W2065846878 @default.
• W2160344881 cites W2067177429 @default.
• W2160344881 cites W2070512415 @default.
• W2160344881 cites W2092387745 @default.
• W2160344881 cites W2093905196 @default.
• W2160344881 cites W2101818418 @default.
• W2160344881 cites W2103997560 @default.
• W2160344881 cites W2104952200 @default.
• W2160344881 cites W2104954806 @default.
• W2160344881 cites W2110335151 @default.
• W2160344881 cites W2115011276 @default.
• W2160344881 cites W2116117847 @default.
• W2160344881 cites W2124638545 @default.
• W2160344881 cites W2125353305 @default.
• W2160344881 cites W2125402548 @default.
• W2160344881 cites W2125512106 @default.
• W2160344881 cites W2138360835 @default.
• W2160344881 cites W2139301359 @default.
• W2160344881 cites W2145130294 @default.
• W2160344881 cites W2145947173 @default.
• W2160344881 cites W2150444353 @default.
• W2160344881 cites W2152076818 @default.
• W2160344881 cites W2155292801 @default.
• W2160344881 cites W2155761127 @default.
• W2160344881 cites W2162109874 @default.
• W2160344881 cites W2226416434 @default.
• W2160344881 cites W2319909071 @default.
• W2160344881 cites W4235182877 @default.
• W2160344881 doi "https://doi.org/10.1093/gbe/evu240" @default.
• W2160344881 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4255772" @default.
• W2160344881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25359921" @default.
• W2160344881 hasPublicationYear "2014" @default.
• W2160344881 type Work @default.
• W2160344881 sameAs 2160344881 @default.
• W2160344881 citedByCount "9" @default.
• W2160344881 countsByYear W21603448812015 @default.
• W2160344881 countsByYear W21603448812016 @default.
• W2160344881 countsByYear W21603448812017 @default.
• W2160344881 countsByYear W21603448812018 @default.
• W2160344881 countsByYear W21603448812020 @default.
• W2160344881 countsByYear W21603448812021 @default.
• W2160344881 crossrefType "journal-article" @default.
• W2160344881 hasAuthorship W2160344881A5013829079 @default.
• W2160344881 hasAuthorship W2160344881A5020998052 @default.
• W2160344881 hasAuthorship W2160344881A5021061692 @default.
• W2160344881 hasAuthorship W2160344881A5052171878 @default.
• W2160344881 hasAuthorship W2160344881A5061741483 @default.
• W2160344881 hasBestOaLocation W21603448811 @default.
• W2160344881 hasConcept C104292427 @default.
• W2160344881 hasConcept C104317684 @default.
• W2160344881 hasConcept C123249941 @default.
• W2160344881 hasConcept C141231307 @default.
• W2160344881 hasConcept C24586158 @default.
• W2160344881 hasConcept C28859421 @default.
• W2160344881 hasConcept C54355233 @default.
• W2160344881 hasConcept C552990157 @default.
• W2160344881 hasConcept C70721500 @default.
• W2160344881 hasConcept C7386963 @default.
• W2160344881 hasConcept C78458016 @default.
• W2160344881 hasConcept C86803240 @default.
• W2160344881 hasConceptScore W2160344881C104292427 @default.
• W2160344881 hasConceptScore W2160344881C104317684 @default.
• W2160344881 hasConceptScore W2160344881C123249941 @default.
• W2160344881 hasConceptScore W2160344881C141231307 @default.
• W2160344881 hasConceptScore W2160344881C24586158 @default.
• W2160344881 hasConceptScore W2160344881C28859421 @default.
• W2160344881 hasConceptScore W2160344881C54355233 @default.
• W2160344881 hasConceptScore W2160344881C552990157 @default.
• W2160344881 hasConceptScore W2160344881C70721500 @default.
• W2160344881 hasConceptScore W2160344881C7386963 @default.
• W2160344881 hasConceptScore W2160344881C78458016 @default.
• W2160344881 hasConceptScore W2160344881C86803240 @default.
• W2160344881 hasIssue "11" @default.
• W2160344881 hasLocation W21603448811 @default.

• next