FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160352058> ?p ?o ?g. }

• W2160352058 endingPage "576" @default.
• W2160352058 startingPage "562" @default.
• W2160352058 abstract "To investigate the range of antigenic variation of HBV capsids, we have characterized the epitopes for two anti-capsid antibodies by cryo-electron microscopy and image reconstruction of Fab-labeled capsids to ∼10 Å resolution followed by molecular modeling. Both antibodies engage residues on the protruding spikes but their epitopes and binding orientations differ. Steric interference effects limit maximum binding to ∼50% average occupancy in each case. However, the occupancies of the two copies of a given epitope that are present on a single spike differ, reflecting subtle distinctions in structure and hence, binding affinity, arising from quasi-equivalence. The epitope for mAb88 is conformational but continuous, consisting of a loop–helix motif (residues 77–87) on one of the two polypeptide chains in the spike. In contrast, the epitope for mAb842, like most conformational epitopes, is discontinuous, consisting of a loop on one polypeptide chain (residues 74–78) combined with a loop–helix element (residues 78–83) on the other. The epitope of mAb842 is essentially identical with that previously mapped for mAb F11A4, although the binding orientations of the two monoclonal antibodies (mAbs) differ, as do their affinities measured by surface plasmon resonance. From the number of monoclonals (six) whose binding had to be characterized to give the first duplicate epitope, we estimate the total number of core antigen (cAg) epitopes to be of the order of 20. Given that different antibodies may share the same epitope, the potential number of distinct anti-cAg clones should be considerably higher. The observation that the large majority of cAg epitopes are conformational reflects the relative dimensions of a Fab (large) and the small size and close packing of the motifs that are exposed and accessible on the capsid surface." @default.
• W2160352058 created "2016-06-24" @default.
• W2160352058 creator A5009561892 @default.
• W2160352058 creator A5020229008 @default.
• W2160352058 creator A5023944515 @default.
• W2160352058 creator A5034367279 @default.
• W2160352058 creator A5034596312 @default.
• W2160352058 creator A5039450859 @default.
• W2160352058 creator A5065079947 @default.
• W2160352058 creator A5090643634 @default.
• W2160352058 creator A5090969844 @default.
• W2160352058 date "2006-01-01" @default.
• W2160352058 modified "2023-10-11" @default.
• W2160352058 title "Epitope Diversity of Hepatitis B Virus Capsids: Quasi-equivalent Variations in Spike Epitopes and Binding of Different Antibodies to the same Epitope" @default.
• W2160352058 cites W1506907307 @default.
• W2160352058 cites W1517213149 @default.
• W2160352058 cites W1579300767 @default.
• W2160352058 cites W1813446025 @default.
• W2160352058 cites W1816183039 @default.
• W2160352058 cites W1889703995 @default.
• W2160352058 cites W1922003631 @default.
• W2160352058 cites W1928945856 @default.
• W2160352058 cites W1967075825 @default.
• W2160352058 cites W1968002980 @default.
• W2160352058 cites W1970274365 @default.
• W2160352058 cites W1972942325 @default.
• W2160352058 cites W1975962007 @default.
• W2160352058 cites W1989164610 @default.
• W2160352058 cites W1990341264 @default.
• W2160352058 cites W1991214219 @default.
• W2160352058 cites W1994714992 @default.
• W2160352058 cites W2002860344 @default.
• W2160352058 cites W2007107624 @default.
• W2160352058 cites W2010024509 @default.
• W2160352058 cites W2010224214 @default.
• W2160352058 cites W2013083986 @default.
• W2160352058 cites W2013404658 @default.
• W2160352058 cites W2015628141 @default.
• W2160352058 cites W2024431338 @default.
• W2160352058 cites W2025031437 @default.
• W2160352058 cites W2025686042 @default.
• W2160352058 cites W2041526132 @default.
• W2160352058 cites W2042646182 @default.
• W2160352058 cites W2048024207 @default.
• W2160352058 cites W2048147356 @default.
• W2160352058 cites W2048385123 @default.
• W2160352058 cites W2050712341 @default.
• W2160352058 cites W2056947674 @default.
• W2160352058 cites W2061293221 @default.
• W2160352058 cites W2062060027 @default.
• W2160352058 cites W2062908734 @default.
• W2160352058 cites W2064811345 @default.
• W2160352058 cites W2066052459 @default.
• W2160352058 cites W2066686626 @default.
• W2160352058 cites W2068527596 @default.
• W2160352058 cites W2073557651 @default.
• W2160352058 cites W2078507839 @default.
• W2160352058 cites W2079025991 @default.
• W2160352058 cites W2080187599 @default.
• W2160352058 cites W2083445427 @default.
• W2160352058 cites W2084773876 @default.
• W2160352058 cites W2090013975 @default.
• W2160352058 cites W2094869942 @default.
• W2160352058 cites W2102814038 @default.
• W2160352058 cites W2111873803 @default.
• W2160352058 cites W2113118666 @default.
• W2160352058 cites W2116392806 @default.
• W2160352058 cites W2130479394 @default.
• W2160352058 cites W2144825747 @default.
• W2160352058 cites W2151929417 @default.
• W2160352058 cites W2152986015 @default.
• W2160352058 cites W2165068435 @default.
• W2160352058 cites W2165102205 @default.
• W2160352058 cites W2166954066 @default.
• W2160352058 doi "https://doi.org/10.1016/j.jmb.2005.10.035" @default.
• W2160352058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16309704" @default.
• W2160352058 hasPublicationYear "2006" @default.
• W2160352058 type Work @default.
• W2160352058 sameAs 2160352058 @default.
• W2160352058 citedByCount "26" @default.
• W2160352058 countsByYear W21603520582012 @default.
• W2160352058 countsByYear W21603520582013 @default.
• W2160352058 countsByYear W21603520582014 @default.
• W2160352058 countsByYear W21603520582015 @default.
• W2160352058 countsByYear W21603520582016 @default.
• W2160352058 countsByYear W21603520582020 @default.
• W2160352058 countsByYear W21603520582023 @default.
• W2160352058 crossrefType "journal-article" @default.
• W2160352058 hasAuthorship W2160352058A5009561892 @default.
• W2160352058 hasAuthorship W2160352058A5020229008 @default.
• W2160352058 hasAuthorship W2160352058A5023944515 @default.
• W2160352058 hasAuthorship W2160352058A5034367279 @default.
• W2160352058 hasAuthorship W2160352058A5034596312 @default.
• W2160352058 hasAuthorship W2160352058A5039450859 @default.
• W2160352058 hasAuthorship W2160352058A5065079947 @default.
• W2160352058 hasAuthorship W2160352058A5090643634 @default.
• W2160352058 hasAuthorship W2160352058A5090969844 @default.
• W2160352058 hasConcept C12554922 @default.

• next