FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160357082> ?p ?o ?g. }

• W2160357082 endingPage "514" @default.
• W2160357082 startingPage "501" @default.
• W2160357082 abstract "The nitromethylene heterocyclic compound 2(nitromethylene)tetrahydro)1,3-thiazine (NMTHT) inhibits the binding of [125I]alpha-bungarotoxin to membranes prepared from cockroach (Periplaneta americana) nerve cord and fish (Torpedo californica) electric organ. Electrophysiological studies on the cockroach fast coxal depressor motorneuron (Df) reveal a dose-dependent depolarization in response to bath-applied NMTHT. Responses to ionophoretic application of NMTHT onto the cell-body membrane of motorneuron Df are suppressed by bath-applied mecamylamine (1.0 x 10(-4) M) and alpha-bungarotoxin (1.0 x 10(-7) M). These findings, together with the detection of a reversal potential close to that estimated for acetylcholine, provide evidence for an agonist action of this nitromethylene on an insect neuronal nicotinic acetylcholine receptor. The binding of [3H]H12-histrionicotoxin to Torpedo membranes was enhanced in the presence of NMTHT indicating an agonist action at this vertebrate peripheral nicotinic acetylcholine receptor. NMTHT is ineffective in radioligand binding assays for rat brain GABAA receptors, rat brain L-glutamate receptors and insect (Musca domestica) L-glutamate receptors. Partial block of rat brain muscarinic acetylcholine receptors is detected at millimolar concentrations of NMTHT. Thus nitromethylenes appear to exhibit selectivity for acetylcholine receptors and exhibit an agonist action at nicotinic acetylcholine receptors." @default.
• W2160357082 created "2016-06-24" @default.
• W2160357082 creator A5000977660 @default.
• W2160357082 creator A5031887765 @default.
• W2160357082 creator A5035900980 @default.
• W2160357082 creator A5053484252 @default.
• W2160357082 creator A5054742342 @default.
• W2160357082 creator A5059817376 @default.
• W2160357082 creator A5064308390 @default.
• W2160357082 creator A5089843879 @default.
• W2160357082 date "1989-09-22" @default.
• W2160357082 modified "2023-10-01" @default.
• W2160357082 title "Actions of the insecticide 2 (nitromethylene) tetrahydro-1, 3-thiazine on insect and vertebrate nicotinic acetylcholine receptors" @default.
• W2160357082 cites W1469742352 @default.
• W2160357082 cites W152688295 @default.
• W2160357082 cites W1588386708 @default.
• W2160357082 cites W159368309 @default.
• W2160357082 cites W1966428196 @default.
• W2160357082 cites W1978591672 @default.
• W2160357082 cites W1980876268 @default.
• W2160357082 cites W1997366221 @default.
• W2160357082 cites W2001946503 @default.
• W2160357082 cites W2006122719 @default.
• W2160357082 cites W2009224927 @default.
• W2160357082 cites W2010682722 @default.
• W2160357082 cites W2024234388 @default.
• W2160357082 cites W2031003228 @default.
• W2160357082 cites W2038665315 @default.
• W2160357082 cites W2045424199 @default.
• W2160357082 cites W2049342838 @default.
• W2160357082 cites W2049816249 @default.
• W2160357082 cites W2054947117 @default.
• W2160357082 cites W2066628109 @default.
• W2160357082 cites W2072928811 @default.
• W2160357082 cites W2075624817 @default.
• W2160357082 cites W2082722080 @default.
• W2160357082 doi "https://doi.org/10.1098/rspb.1989.0062" @default.
• W2160357082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2479949" @default.
• W2160357082 hasPublicationYear "1989" @default.
• W2160357082 type Work @default.
• W2160357082 sameAs 2160357082 @default.
• W2160357082 citedByCount "58" @default.
• W2160357082 countsByYear W21603570822013 @default.
• W2160357082 countsByYear W21603570822015 @default.
• W2160357082 countsByYear W21603570822016 @default.
• W2160357082 countsByYear W21603570822017 @default.
• W2160357082 countsByYear W21603570822018 @default.
• W2160357082 countsByYear W21603570822020 @default.
• W2160357082 countsByYear W21603570822022 @default.
• W2160357082 crossrefType "journal-article" @default.
• W2160357082 hasAuthorship W2160357082A5000977660 @default.
• W2160357082 hasAuthorship W2160357082A5031887765 @default.
• W2160357082 hasAuthorship W2160357082A5035900980 @default.
• W2160357082 hasAuthorship W2160357082A5053484252 @default.
• W2160357082 hasAuthorship W2160357082A5054742342 @default.
• W2160357082 hasAuthorship W2160357082A5059817376 @default.
• W2160357082 hasAuthorship W2160357082A5064308390 @default.
• W2160357082 hasAuthorship W2160357082A5089843879 @default.
• W2160357082 hasConcept C12554922 @default.
• W2160357082 hasConcept C170493617 @default.
• W2160357082 hasConcept C185592680 @default.
• W2160357082 hasConcept C188987157 @default.
• W2160357082 hasConcept C18903297 @default.
• W2160357082 hasConcept C2775910092 @default.
• W2160357082 hasConcept C2776880047 @default.
• W2160357082 hasConcept C2777346155 @default.
• W2160357082 hasConcept C2778938600 @default.
• W2160357082 hasConcept C2779570518 @default.
• W2160357082 hasConcept C33789571 @default.
• W2160357082 hasConcept C45855136 @default.
• W2160357082 hasConcept C51927110 @default.
• W2160357082 hasConcept C55493867 @default.
• W2160357082 hasConcept C80161118 @default.
• W2160357082 hasConcept C86803240 @default.
• W2160357082 hasConcept C98274493 @default.
• W2160357082 hasConceptScore W2160357082C12554922 @default.
• W2160357082 hasConceptScore W2160357082C170493617 @default.
• W2160357082 hasConceptScore W2160357082C185592680 @default.
• W2160357082 hasConceptScore W2160357082C188987157 @default.
• W2160357082 hasConceptScore W2160357082C18903297 @default.
• W2160357082 hasConceptScore W2160357082C2775910092 @default.
• W2160357082 hasConceptScore W2160357082C2776880047 @default.
• W2160357082 hasConceptScore W2160357082C2777346155 @default.
• W2160357082 hasConceptScore W2160357082C2778938600 @default.
• W2160357082 hasConceptScore W2160357082C2779570518 @default.
• W2160357082 hasConceptScore W2160357082C33789571 @default.
• W2160357082 hasConceptScore W2160357082C45855136 @default.
• W2160357082 hasConceptScore W2160357082C51927110 @default.
• W2160357082 hasConceptScore W2160357082C55493867 @default.
• W2160357082 hasConceptScore W2160357082C80161118 @default.
• W2160357082 hasConceptScore W2160357082C86803240 @default.
• W2160357082 hasConceptScore W2160357082C98274493 @default.
• W2160357082 hasIssue "1289" @default.
• W2160357082 hasLocation W21603570821 @default.
• W2160357082 hasLocation W21603570822 @default.
• W2160357082 hasOpenAccess W2160357082 @default.
• W2160357082 hasPrimaryLocation W21603570821 @default.
• W2160357082 hasRelatedWork W175747868 @default.

• next