FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160359265> ?p ?o ?g. }

• W2160359265 endingPage "687" @default.
• W2160359265 startingPage "681" @default.
• W2160359265 abstract "Two popular complementary, alternative, and integrative medicine therapies, high-dose intravenous ascorbic acid (AA) and intravenous glutathione (GSH), are often coadministered to cancer patients with unclear efficacy and drug–drug interaction. In this study we provide the first survey evidence for clinical use of iv GSH with iv AA. To address questions of efficacy and drug–drug interaction, we tested 10 cancer cell lines with AA, GSH, and their combination. The results showed that pharmacologic AA induced cytotoxicity in all tested cancer cells, with IC50 less than 4 mM, a concentration easily achievable in humans. GSH reduced cytotoxicity by 10–95% by attenuating AA-induced H2O2 production. Treatment in mouse pancreatic cancer xenografts showed that intraperitoneal AA at 4 g/kg daily reduced tumor volume by 42%. Addition of intraperitoneal GSH inhibited the AA-induced tumor volume reduction. Although all treatments (AA, GSH, and AA + GSH) improved survival rate, AA + GSH inhibited the cytotoxic effect of AA alone and failed to provide further survival benefit. These data confirm the pro-oxidative anti-cancer mechanism of pharmacologic AA and suggest that AA and GSH administered together provide no additional benefit compared with AA alone. There is an antagonism between ascorbate and glutathione in treating cancer, and therefore iv AA and iv GSH should not be coadministered to cancer patients on the same day." @default.
• W2160359265 created "2016-06-24" @default.
• W2160359265 creator A5014708668 @default.
• W2160359265 creator A5053160815 @default.
• W2160359265 creator A5065701833 @default.
• W2160359265 creator A5071621068 @default.
• W2160359265 creator A5073123567 @default.
• W2160359265 date "2011-08-01" @default.
• W2160359265 modified "2023-10-07" @default.
• W2160359265 title "Anti-cancer effect of pharmacologic ascorbate and its interaction with supplementary parenteral glutathione in preclinical cancer models" @default.
• W2160359265 cites W1489116618 @default.
• W2160359265 cites W1891967301 @default.
• W2160359265 cites W1949043027 @default.
• W2160359265 cites W1955012509 @default.
• W2160359265 cites W1970034280 @default.
• W2160359265 cites W1972779889 @default.
• W2160359265 cites W1980763729 @default.
• W2160359265 cites W1983232483 @default.
• W2160359265 cites W1984543805 @default.
• W2160359265 cites W1996185815 @default.
• W2160359265 cites W2000112260 @default.
• W2160359265 cites W2006004077 @default.
• W2160359265 cites W2006613730 @default.
• W2160359265 cites W2010756713 @default.
• W2160359265 cites W2011352354 @default.
• W2160359265 cites W2011375826 @default.
• W2160359265 cites W2013092934 @default.
• W2160359265 cites W2021610255 @default.
• W2160359265 cites W2025061897 @default.
• W2160359265 cites W2046750894 @default.
• W2160359265 cites W2052158255 @default.
• W2160359265 cites W2056840435 @default.
• W2160359265 cites W2069096457 @default.
• W2160359265 cites W2071756286 @default.
• W2160359265 cites W2076031397 @default.
• W2160359265 cites W2076985939 @default.
• W2160359265 cites W2079974656 @default.
• W2160359265 cites W2080559885 @default.
• W2160359265 cites W2081964855 @default.
• W2160359265 cites W2107741115 @default.
• W2160359265 cites W2108045872 @default.
• W2160359265 cites W2111713222 @default.
• W2160359265 cites W2112645157 @default.
• W2160359265 cites W2119115728 @default.
• W2160359265 cites W2120998010 @default.
• W2160359265 cites W2133373817 @default.
• W2160359265 cites W2140968862 @default.
• W2160359265 cites W2150221577 @default.
• W2160359265 cites W2151544145 @default.
• W2160359265 cites W2156533107 @default.
• W2160359265 cites W2157653515 @default.
• W2160359265 cites W2159099334 @default.
• W2160359265 cites W2332542469 @default.
• W2160359265 cites W2333401880 @default.
• W2160359265 cites W2418831570 @default.
• W2160359265 cites W4242872483 @default.
• W2160359265 doi "https://doi.org/10.1016/j.freeradbiomed.2011.05.031" @default.
• W2160359265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21672627" @default.
• W2160359265 hasPublicationYear "2011" @default.
• W2160359265 type Work @default.
• W2160359265 sameAs 2160359265 @default.
• W2160359265 citedByCount "42" @default.
• W2160359265 countsByYear W21603592652012 @default.
• W2160359265 countsByYear W21603592652013 @default.
• W2160359265 countsByYear W21603592652014 @default.
• W2160359265 countsByYear W21603592652015 @default.
• W2160359265 countsByYear W21603592652016 @default.
• W2160359265 countsByYear W21603592652017 @default.
• W2160359265 countsByYear W21603592652018 @default.
• W2160359265 countsByYear W21603592652019 @default.
• W2160359265 countsByYear W21603592652020 @default.
• W2160359265 countsByYear W21603592652021 @default.
• W2160359265 countsByYear W21603592652022 @default.
• W2160359265 countsByYear W21603592652023 @default.
• W2160359265 crossrefType "journal-article" @default.
• W2160359265 hasAuthorship W2160359265A5014708668 @default.
• W2160359265 hasAuthorship W2160359265A5053160815 @default.
• W2160359265 hasAuthorship W2160359265A5065701833 @default.
• W2160359265 hasAuthorship W2160359265A5071621068 @default.
• W2160359265 hasAuthorship W2160359265A5073123567 @default.
• W2160359265 hasConcept C109316439 @default.
• W2160359265 hasConcept C121608353 @default.
• W2160359265 hasConcept C126322002 @default.
• W2160359265 hasConcept C181199279 @default.
• W2160359265 hasConcept C185592680 @default.
• W2160359265 hasConcept C202751555 @default.
• W2160359265 hasConcept C2780035454 @default.
• W2160359265 hasConcept C2986274086 @default.
• W2160359265 hasConcept C31903555 @default.
• W2160359265 hasConcept C538909803 @default.
• W2160359265 hasConcept C55493867 @default.
• W2160359265 hasConcept C71924100 @default.
• W2160359265 hasConcept C96232424 @default.
• W2160359265 hasConcept C98274493 @default.
• W2160359265 hasConceptScore W2160359265C109316439 @default.
• W2160359265 hasConceptScore W2160359265C121608353 @default.
• W2160359265 hasConceptScore W2160359265C126322002 @default.
• W2160359265 hasConceptScore W2160359265C181199279 @default.

• next