Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160360076> ?p ?o ?g. }
- W2160360076 endingPage "777" @default.
- W2160360076 startingPage "770" @default.
- W2160360076 abstract "Although l-3,4-dihydroxyphenylalanine (l-dopa) is one of the most effective therapies for Parkinson9s disease, continued treatment may result in excessive involuntary movements known as l-dopa-induced dyskinesias (LIDs). Because LIDs can become dose-limiting, there is great interest in finding ways to ameliorate or prevent this troubling side effect of l-dopa therapy. It was recently reported that the D3 receptor partial agonist BP897 [<i>N</i>-[4-(4-(2-methoxyphenyl)piperazinyl)butyl]-2-naphthamide] reduces LIDs without diminishing antiparkinsonian effects of l-dopa in macaques. In the present study, we tested the effects of BP897 on LIDs in squirrel monkeys, a nonhuman primate particularly prone to dyskinesias. Parkinsonism was induced using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Animals were then gavaged with l-dopa/carbidopa (7.5 or 15 mg/kg/dose) without and with BP897. The effects of BP897 treatment were evaluated on several components of LIDs, including time course, peak dyskinesias, and area under the curve (AUC), a measure that encompasses both peak and duration of the response. Analyses of the time course and overall dyskinetic response (AUC) showed that BP897 significantly reduced LIDs but at the expense of the antiparkinsonian effect of l-dopa. BP897 had no significant effect on peak dyskinesias. Correlation studies showed that beneficial effects of BP897 on dyskinesias were linked to a decline in the antiparkinsonian action of l-dopa. Analyses of a subgroup of animals with mild/moderate parkinsonism yielded comparable results. Thus, in squirrel monkeys in contrast to macaques, BP897 fails to exert an antidyskinetic effect without diminishing the antiparkinsonian effects of l-dopa. These results suggest that BP897 may be less effective than originally anticipated for treating LIDs in Parkinson9s disease." @default.
- W2160360076 created "2016-06-24" @default.
- W2160360076 creator A5004190849 @default.
- W2160360076 creator A5022945644 @default.
- W2160360076 creator A5024116361 @default.
- W2160360076 creator A5025397950 @default.
- W2160360076 creator A5035849217 @default.
- W2160360076 creator A5041316953 @default.
- W2160360076 creator A5090663988 @default.
- W2160360076 date "2004-06-29" @default.
- W2160360076 modified "2023-10-06" @default.
- W2160360076 title "Effect of the D3 Dopamine Receptor Partial Agonist BP897 [<i>N</i>-[4-(4-(2-Methoxyphenyl)piperazinyl)butyl]-2-naphthamide] on l-3,4-Dihydroxyphenylalanine-Induced Dyskinesias and Parkinsonism in Squirrel Monkeys" @default.
- W2160360076 cites W1506920637 @default.
- W2160360076 cites W1925492557 @default.
- W2160360076 cites W1966092598 @default.
- W2160360076 cites W1978055974 @default.
- W2160360076 cites W1981379480 @default.
- W2160360076 cites W1981821582 @default.
- W2160360076 cites W1987100967 @default.
- W2160360076 cites W1990307683 @default.
- W2160360076 cites W1998471342 @default.
- W2160360076 cites W2000728885 @default.
- W2160360076 cites W2010206955 @default.
- W2160360076 cites W2017424741 @default.
- W2160360076 cites W2023239525 @default.
- W2160360076 cites W2034945701 @default.
- W2160360076 cites W2036218676 @default.
- W2160360076 cites W2040944670 @default.
- W2160360076 cites W2048937194 @default.
- W2160360076 cites W2060645127 @default.
- W2160360076 cites W2061359205 @default.
- W2160360076 cites W2076989093 @default.
- W2160360076 cites W2083510711 @default.
- W2160360076 cites W2085418343 @default.
- W2160360076 cites W2090535731 @default.
- W2160360076 cites W2098652452 @default.
- W2160360076 cites W2103172333 @default.
- W2160360076 cites W2110987175 @default.
- W2160360076 cites W2115222037 @default.
- W2160360076 cites W2143959688 @default.
- W2160360076 cites W85304509 @default.
- W2160360076 doi "https://doi.org/10.1124/jpet.104.071142" @default.
- W2160360076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15226382" @default.
- W2160360076 hasPublicationYear "2004" @default.
- W2160360076 type Work @default.
- W2160360076 sameAs 2160360076 @default.
- W2160360076 citedByCount "42" @default.
- W2160360076 countsByYear W21603600762012 @default.
- W2160360076 countsByYear W21603600762013 @default.
- W2160360076 countsByYear W21603600762014 @default.
- W2160360076 countsByYear W21603600762015 @default.
- W2160360076 countsByYear W21603600762018 @default.
- W2160360076 countsByYear W21603600762020 @default.
- W2160360076 countsByYear W21603600762021 @default.
- W2160360076 crossrefType "journal-article" @default.
- W2160360076 hasAuthorship W2160360076A5004190849 @default.
- W2160360076 hasAuthorship W2160360076A5022945644 @default.
- W2160360076 hasAuthorship W2160360076A5024116361 @default.
- W2160360076 hasAuthorship W2160360076A5025397950 @default.
- W2160360076 hasAuthorship W2160360076A5035849217 @default.
- W2160360076 hasAuthorship W2160360076A5041316953 @default.
- W2160360076 hasAuthorship W2160360076A5090663988 @default.
- W2160360076 hasConcept C120069818 @default.
- W2160360076 hasConcept C126322002 @default.
- W2160360076 hasConcept C137183658 @default.
- W2160360076 hasConcept C15744967 @default.
- W2160360076 hasConcept C169760540 @default.
- W2160360076 hasConcept C170493617 @default.
- W2160360076 hasConcept C199596767 @default.
- W2160360076 hasConcept C2776030879 @default.
- W2160360076 hasConcept C2776525014 @default.
- W2160360076 hasConcept C2776754145 @default.
- W2160360076 hasConcept C2777440324 @default.
- W2160360076 hasConcept C2778674702 @default.
- W2160360076 hasConcept C2778938600 @default.
- W2160360076 hasConcept C2779134260 @default.
- W2160360076 hasConcept C2779734285 @default.
- W2160360076 hasConcept C2780304432 @default.
- W2160360076 hasConcept C2780405171 @default.
- W2160360076 hasConcept C513476851 @default.
- W2160360076 hasConcept C58732023 @default.
- W2160360076 hasConcept C71924100 @default.
- W2160360076 hasConcept C98274493 @default.
- W2160360076 hasConceptScore W2160360076C120069818 @default.
- W2160360076 hasConceptScore W2160360076C126322002 @default.
- W2160360076 hasConceptScore W2160360076C137183658 @default.
- W2160360076 hasConceptScore W2160360076C15744967 @default.
- W2160360076 hasConceptScore W2160360076C169760540 @default.
- W2160360076 hasConceptScore W2160360076C170493617 @default.
- W2160360076 hasConceptScore W2160360076C199596767 @default.
- W2160360076 hasConceptScore W2160360076C2776030879 @default.
- W2160360076 hasConceptScore W2160360076C2776525014 @default.
- W2160360076 hasConceptScore W2160360076C2776754145 @default.
- W2160360076 hasConceptScore W2160360076C2777440324 @default.
- W2160360076 hasConceptScore W2160360076C2778674702 @default.
- W2160360076 hasConceptScore W2160360076C2778938600 @default.
- W2160360076 hasConceptScore W2160360076C2779134260 @default.
- W2160360076 hasConceptScore W2160360076C2779734285 @default.