Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160363565> ?p ?o ?g. }
- W2160363565 endingPage "e2297" @default.
- W2160363565 startingPage "e2297" @default.
- W2160363565 abstract "In the cerebellum, Delphilin is expressed selectively in Purkinje cells (PCs) and is localized exclusively at parallel fiber (PF) synapses, where it interacts with glutamate receptor (GluR) δ2 that is essential for long-term depression (LTD), motor learning and cerebellar wiring. Delphilin ablation exerted little effect on the synaptic localization of GluRδ2. There were no detectable abnormalities in cerebellar histology, PC cytology and PC synapse formation in contrast to GluRδ2 mutant mice. However, LTD induction was facilitated at PF-PC synapses in Delphilin mutant mice. Intracellular Ca2+ required for the induction of LTD appeared to be reduced in the mutant mice, while Ca2+ influx through voltage-gated Ca2+ channels and metabotropic GluR1-mediated slow synaptic response were similar between wild-type and mutant mice. We further showed that the gain-increase adaptation of the optokinetic response (OKR) was enhanced in the mutant mice. These findings are compatible with the idea that LTD induction at PF-PC synapses is a crucial rate-limiting step in OKR gain-increase adaptation, a simple form of motor learning. As exemplified in this study, enhancing synaptic plasticity at a specific synaptic site of a neural network is a useful approach to understanding the roles of multiple plasticity mechanisms at various cerebellar synapses in motor control and learning." @default.
- W2160363565 created "2016-06-24" @default.
- W2160363565 creator A5014891638 @default.
- W2160363565 creator A5016740817 @default.
- W2160363565 creator A5017295777 @default.
- W2160363565 creator A5017811687 @default.
- W2160363565 creator A5026509210 @default.
- W2160363565 creator A5027707370 @default.
- W2160363565 creator A5048397528 @default.
- W2160363565 creator A5050127204 @default.
- W2160363565 creator A5053372897 @default.
- W2160363565 creator A5057922139 @default.
- W2160363565 creator A5061509682 @default.
- W2160363565 creator A5075022633 @default.
- W2160363565 creator A5087503871 @default.
- W2160363565 date "2008-05-28" @default.
- W2160363565 modified "2023-09-30" @default.
- W2160363565 title "Enhancement of Both Long-Term Depression Induction and Optokinetic Response Adaptation in Mice Lacking Delphilin" @default.
- W2160363565 cites W1500556256 @default.
- W2160363565 cites W1502963283 @default.
- W2160363565 cites W1523646668 @default.
- W2160363565 cites W1524297322 @default.
- W2160363565 cites W1593745576 @default.
- W2160363565 cites W1608421677 @default.
- W2160363565 cites W1624178692 @default.
- W2160363565 cites W1658796519 @default.
- W2160363565 cites W1828912035 @default.
- W2160363565 cites W1876061808 @default.
- W2160363565 cites W1966383051 @default.
- W2160363565 cites W1977496586 @default.
- W2160363565 cites W1983329616 @default.
- W2160363565 cites W1988724282 @default.
- W2160363565 cites W1992320534 @default.
- W2160363565 cites W1993481663 @default.
- W2160363565 cites W1994039789 @default.
- W2160363565 cites W1995920979 @default.
- W2160363565 cites W1997032972 @default.
- W2160363565 cites W1997875432 @default.
- W2160363565 cites W1998747207 @default.
- W2160363565 cites W1999719682 @default.
- W2160363565 cites W2008113638 @default.
- W2160363565 cites W2010753031 @default.
- W2160363565 cites W2018830009 @default.
- W2160363565 cites W2019066509 @default.
- W2160363565 cites W2032596004 @default.
- W2160363565 cites W2041249898 @default.
- W2160363565 cites W2044355740 @default.
- W2160363565 cites W2047579925 @default.
- W2160363565 cites W2052279706 @default.
- W2160363565 cites W2054657761 @default.
- W2160363565 cites W2055463548 @default.
- W2160363565 cites W2056384807 @default.
- W2160363565 cites W2057047456 @default.
- W2160363565 cites W2058092670 @default.
- W2160363565 cites W2062733687 @default.
- W2160363565 cites W2063691589 @default.
- W2160363565 cites W2068599628 @default.
- W2160363565 cites W2069004234 @default.
- W2160363565 cites W2070501686 @default.
- W2160363565 cites W2074952207 @default.
- W2160363565 cites W2077211332 @default.
- W2160363565 cites W2084877235 @default.
- W2160363565 cites W2100633666 @default.
- W2160363565 cites W2102661539 @default.
- W2160363565 cites W2103019454 @default.
- W2160363565 cites W2105350975 @default.
- W2160363565 cites W2106279406 @default.
- W2160363565 cites W2108091832 @default.
- W2160363565 cites W2114911122 @default.
- W2160363565 cites W2115346246 @default.
- W2160363565 cites W2143186084 @default.
- W2160363565 cites W2143334142 @default.
- W2160363565 cites W2147033427 @default.
- W2160363565 cites W2153397253 @default.
- W2160363565 cites W2155051950 @default.
- W2160363565 cites W2160635048 @default.
- W2160363565 cites W2163423139 @default.
- W2160363565 cites W2166889327 @default.
- W2160363565 cites W2168986469 @default.
- W2160363565 cites W2171370311 @default.
- W2160363565 cites W4293416615 @default.
- W2160363565 cites W4320995227 @default.
- W2160363565 doi "https://doi.org/10.1371/journal.pone.0002297" @default.
- W2160363565 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2386150" @default.
- W2160363565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18509461" @default.
- W2160363565 hasPublicationYear "2008" @default.
- W2160363565 type Work @default.
- W2160363565 sameAs 2160363565 @default.
- W2160363565 citedByCount "50" @default.
- W2160363565 countsByYear W21603635652012 @default.
- W2160363565 countsByYear W21603635652013 @default.
- W2160363565 countsByYear W21603635652014 @default.
- W2160363565 countsByYear W21603635652015 @default.
- W2160363565 countsByYear W21603635652016 @default.
- W2160363565 countsByYear W21603635652017 @default.
- W2160363565 countsByYear W21603635652018 @default.
- W2160363565 countsByYear W21603635652019 @default.
- W2160363565 countsByYear W21603635652020 @default.