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• W2160369364 startingPage "905" @default.
• W2160369364 abstract "Drosophila cellularization and animal cell cytokinesis rely on the coordinated functions of the microfilament and microtubule cytoskeletal systems. To identify new proteins involved in cellularization and cytokinesis, we have conducted a biochemical screen for microfilament/microtubule-associated proteins (MMAPs). 17 MMAPs were identified; seven have been previously implicated in cellularization and/or cytokinesis, including KLP3A, Anillin, Septins, and Dynamin. We now show that a novel MMAP, Lava Lamp (Lva), is also required for cellularization. Lva is a coiled-coil protein and, unlike other proteins previously implicated in cellularization or cytokinesis, it is Golgi associated. Our functional analysis shows that cellularization is dramatically inhibited upon injecting anti-Lva antibodies (IgG and Fab) into embryos. In addition, we show that brefeldin A, a potent inhibitor of membrane trafficking, also inhibits cellularization. Biochemical analysis demonstrates that Lva physically interacts with the MMAPs Spectrin and CLIP190. We suggest that Lva and Spectrin may form a Golgi-based scaffold that mediates the interaction of Golgi bodies with microtubules and facilitates Golgi-derived membrane secretion required for the formation of furrows during cellularization. Our results are consistent with the idea that animal cell cytokinesis depends on both actomyosin-based contraction and Golgi-derived membrane secretion." @default.
• W2160369364 created "2016-06-24" @default.
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• W2160369364 creator A5077563393 @default.
• W2160369364 date "2000-11-13" @default.
• W2160369364 modified "2023-10-06" @default.
• W2160369364 title "Lava Lamp, a Novel Peripheral Golgi Protein, Is Required for <i>Drosophila melanogaster</i> Cellularization" @default.
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• W2160369364 cites W1925184199 @default.
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• W2160369364 cites W1975032789 @default.
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• W2160369364 cites W1976309421 @default.
• W2160369364 cites W1980686404 @default.
• W2160369364 cites W1984613650 @default.
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• W2160369364 cites W2022236187 @default.
• W2160369364 cites W2023359244 @default.
• W2160369364 cites W2024645073 @default.
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• W2160369364 cites W2028527288 @default.
• W2160369364 cites W2030421225 @default.
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• W2160369364 cites W2036312848 @default.
• W2160369364 cites W2036780034 @default.
• W2160369364 cites W2041562226 @default.
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• W2160369364 doi "https://doi.org/10.1083/jcb.151.4.905" @default.
• W2160369364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2169433" @default.
• W2160369364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11076973" @default.
• W2160369364 hasPublicationYear "2000" @default.
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