FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160382989> ?p ?o ?g. }

• W2160382989 endingPage "2984" @default.
• W2160382989 startingPage "2976" @default.
• W2160382989 abstract "Although hemodynamic and metabolic factors are individually implicated in the development of diabetic nephropathy, their interaction has not been defined clearly. In this study, the effects of angiotensin II (Ang II) and advanced glycation end products (AGE) both individually on each other are explored and compared. In the first study arm, Sprague-Dawley rats received a continuous infusion of AGE-modified rat serum albumin (RSA) or unmodified RSA for 4 wk with or without the angiotensin receptor type 1 antagonist valsartan. In the second arm, animals received a continuous infusion of Ang II (58.3 ng/kg per min) with or without the AGE inhibitor pyridoxamine. Components of the intrarenal renin-angiotensin system were measured using real time reverse transcription-PCR, immunohistochemistry, and standard angiotensin-converting enzyme (ACE) activity assays. Renal and serum AGE were quantified by immunohistochemistry, ELISA, and AGE-fluorescence. After an infusion of AGE-RSA, renal expression of angiotensinogen, ACE, renin, and angiotensin receptor type 1 were increased significantly (all P < 0.01), and ACE activity was elevated. This was associated with tubular and glomerular hypertrophy and AGE accumulation, which could be antagonized by valsartan. However, valsartan had no effect on increased filtration fraction associated with an AGE-RSA infusion. At the same time, an infusion of Ang II increased the serum and renal accumulation of AGE and advanced oxidation protein products and induced renal hypertrophy and salt retention that could be antagonized by pyridoxamine. However, pyridoxamine had no effect on renal vasoconstriction manifested by reduced renal blood flow. AGE and Ang II have overlapping activities in the kidney. The beneficial effects of blockade of either pathway underline the importance of this interaction in diabetic renal disease and the aging kidney." @default.
• W2160382989 created "2016-06-24" @default.
• W2160382989 creator A5008098216 @default.
• W2160382989 creator A5011660710 @default.
• W2160382989 creator A5026279118 @default.
• W2160382989 creator A5030776630 @default.
• W2160382989 creator A5048460362 @default.
• W2160382989 creator A5051681827 @default.
• W2160382989 creator A5057346686 @default.
• W2160382989 creator A5079626755 @default.
• W2160382989 creator A5081705050 @default.
• W2160382989 date "2005-10-01" @default.
• W2160382989 modified "2023-10-12" @default.
• W2160382989 title "Interactions between Renin Angiotensin System and Advanced Glycation in the Kidney" @default.
• W2160382989 cites W1672412245 @default.
• W2160382989 cites W1887255777 @default.
• W2160382989 cites W1944881523 @default.
• W2160382989 cites W1945272325 @default.
• W2160382989 cites W1985337441 @default.
• W2160382989 cites W1987298734 @default.
• W2160382989 cites W1991427290 @default.
• W2160382989 cites W1994472047 @default.
• W2160382989 cites W1997626699 @default.
• W2160382989 cites W2017644027 @default.
• W2160382989 cites W2023377229 @default.
• W2160382989 cites W2024685003 @default.
• W2160382989 cites W2025548023 @default.
• W2160382989 cites W2025993194 @default.
• W2160382989 cites W2034751842 @default.
• W2160382989 cites W2050826908 @default.
• W2160382989 cites W2060204625 @default.
• W2160382989 cites W2061810671 @default.
• W2160382989 cites W2065012620 @default.
• W2160382989 cites W2065764145 @default.
• W2160382989 cites W2068793587 @default.
• W2160382989 cites W2074376162 @default.
• W2160382989 cites W2076195680 @default.
• W2160382989 cites W2077798045 @default.
• W2160382989 cites W2084142743 @default.
• W2160382989 cites W2084791180 @default.
• W2160382989 cites W2088785140 @default.
• W2160382989 cites W2112461161 @default.
• W2160382989 cites W2114283061 @default.
• W2160382989 cites W2123723157 @default.
• W2160382989 cites W2133751688 @default.
• W2160382989 cites W2133924990 @default.
• W2160382989 cites W2136898798 @default.
• W2160382989 cites W2140070979 @default.
• W2160382989 cites W2140324784 @default.
• W2160382989 cites W2143624978 @default.
• W2160382989 cites W2147071181 @default.
• W2160382989 cites W2149464736 @default.
• W2160382989 cites W2152947121 @default.
• W2160382989 cites W2154477836 @default.
• W2160382989 cites W2157631070 @default.
• W2160382989 cites W2159220813 @default.
• W2160382989 cites W2272073395 @default.
• W2160382989 cites W4235801676 @default.
• W2160382989 cites W4240860350 @default.
• W2160382989 doi "https://doi.org/10.1681/asn.2005010013" @default.
• W2160382989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16107577" @default.
• W2160382989 hasPublicationYear "2005" @default.
• W2160382989 type Work @default.
• W2160382989 sameAs 2160382989 @default.
• W2160382989 citedByCount "124" @default.
• W2160382989 countsByYear W21603829892012 @default.
• W2160382989 countsByYear W21603829892013 @default.
• W2160382989 countsByYear W21603829892014 @default.
• W2160382989 countsByYear W21603829892015 @default.
• W2160382989 countsByYear W21603829892016 @default.
• W2160382989 countsByYear W21603829892017 @default.
• W2160382989 countsByYear W21603829892018 @default.
• W2160382989 countsByYear W21603829892019 @default.
• W2160382989 countsByYear W21603829892020 @default.
• W2160382989 countsByYear W21603829892021 @default.
• W2160382989 countsByYear W21603829892022 @default.
• W2160382989 countsByYear W21603829892023 @default.
• W2160382989 crossrefType "journal-article" @default.
• W2160382989 hasAuthorship W2160382989A5008098216 @default.
• W2160382989 hasAuthorship W2160382989A5011660710 @default.
• W2160382989 hasAuthorship W2160382989A5026279118 @default.
• W2160382989 hasAuthorship W2160382989A5030776630 @default.
• W2160382989 hasAuthorship W2160382989A5048460362 @default.
• W2160382989 hasAuthorship W2160382989A5051681827 @default.
• W2160382989 hasAuthorship W2160382989A5057346686 @default.
• W2160382989 hasAuthorship W2160382989A5079626755 @default.
• W2160382989 hasAuthorship W2160382989A5081705050 @default.
• W2160382989 hasBestOaLocation W21603829891 @default.
• W2160382989 hasConcept C123915805 @default.
• W2160382989 hasConcept C126322002 @default.
• W2160382989 hasConcept C134018914 @default.
• W2160382989 hasConcept C147990577 @default.
• W2160382989 hasConcept C170493617 @default.
• W2160382989 hasConcept C185592680 @default.
• W2160382989 hasConcept C198710026 @default.
• W2160382989 hasConcept C2777387769 @default.
• W2160382989 hasConcept C2779922275 @default.
• W2160382989 hasConcept C2780091579 @default.

• next