FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160405912> ?p ?o ?g. }

• W2160405912 endingPage "1166" @default.
• W2160405912 startingPage "1157" @default.
• W2160405912 abstract "Previously, we have shown that ethanol (EtOH) stimulates a rapid increase in the ciliary beat frequency (CBF) of bovine bronchial epithelial cells (BBECs) via the activation of PKA. We have also shown that inhibitors of nitric oxide synthase block EtOH-stimulated increases in CBF. We hypothesize that EtOH acutely stimulates CBF via the activation of both PKA and PKG pathways. Using chemiluminescence detection of nitric oxide (NO), we directly measured increases in NO production in BBECs treated with 100 mmol/L of EtOH beginning at 25 minutes. Pretreatment of BBECs with guanylyl cyclase inhibitors, ODQ or LY83583, resulted in the inhibition of EtOH-stimulated CBF. Low concentrations (1 nmol/L) of cyclic nucleotide analogues do not stimulate CBF increases. However, a combination of both 1 nmol/L of 8Br-cAMP and 8Br-cGMP stimulates a significant increase over baseline CBF. This effect could be blocked by pretreating BBECs with inhibitors of either PKA or PKG. Very high concentrations of either 8Br-cAMP or 8Br-cGMP (> or =100 micromol/L) were required to cross-activate both PKA and PKG. This suggests that cross-activation of PKA by cGMP is not occurring at the concentrations (1 nmol/L) capable of stimulating CBF. 8-pCPT-cGMPS, an antagonist analogue to cGMP, blocked EtOH-stimulated PKA activity increases. These data support that EtOH-stimulated increases in CBF require the dual activation of both PKA (via cAMP) and PKG (via NO)." @default.
• W2160405912 created "2016-06-24" @default.
• W2160405912 creator A5030545609 @default.
• W2160405912 creator A5046186733 @default.
• W2160405912 creator A5087838903 @default.
• W2160405912 date "2003-09-01" @default.
• W2160405912 modified "2023-10-08" @default.
• W2160405912 title "Ethanol Stimulates Ciliary Beating by Dual Cyclic Nucleotide Kinase Activation in Bovine Bronchial Epithelial Cells" @default.
• W2160405912 cites W110557356 @default.
• W2160405912 cites W1458204101 @default.
• W2160405912 cites W1495743919 @default.
• W2160405912 cites W1516116779 @default.
• W2160405912 cites W1544002341 @default.
• W2160405912 cites W1630357099 @default.
• W2160405912 cites W1893352705 @default.
• W2160405912 cites W1949768730 @default.
• W2160405912 cites W1963999476 @default.
• W2160405912 cites W1973630001 @default.
• W2160405912 cites W1979886397 @default.
• W2160405912 cites W1983971263 @default.
• W2160405912 cites W1993362239 @default.
• W2160405912 cites W200874088 @default.
• W2160405912 cites W2012595732 @default.
• W2160405912 cites W2023379842 @default.
• W2160405912 cites W2023858538 @default.
• W2160405912 cites W2026718479 @default.
• W2160405912 cites W2030248898 @default.
• W2160405912 cites W2032374099 @default.
• W2160405912 cites W2043298240 @default.
• W2160405912 cites W2050734291 @default.
• W2160405912 cites W2051158361 @default.
• W2160405912 cites W2056407483 @default.
• W2160405912 cites W2071146817 @default.
• W2160405912 cites W2083043369 @default.
• W2160405912 cites W2083303225 @default.
• W2160405912 cites W2085290675 @default.
• W2160405912 cites W2102953622 @default.
• W2160405912 cites W2107292572 @default.
• W2160405912 cites W2110354117 @default.
• W2160405912 cites W2121159616 @default.
• W2160405912 cites W2122621769 @default.
• W2160405912 cites W2128635872 @default.
• W2160405912 cites W2143505314 @default.
• W2160405912 cites W2146240100 @default.
• W2160405912 cites W2148828555 @default.
• W2160405912 cites W2155918292 @default.
• W2160405912 cites W2167051481 @default.
• W2160405912 cites W2167064723 @default.
• W2160405912 cites W2233150443 @default.
• W2160405912 cites W2240035390 @default.
• W2160405912 cites W2251920431 @default.
• W2160405912 cites W2255243693 @default.
• W2160405912 cites W2301238968 @default.
• W2160405912 cites W2326733587 @default.
• W2160405912 cites W2400697150 @default.
• W2160405912 cites W2402741840 @default.
• W2160405912 cites W2407869812 @default.
• W2160405912 cites W2415459218 @default.
• W2160405912 cites W2434593122 @default.
• W2160405912 cites W2471652817 @default.
• W2160405912 cites W2471967175 @default.
• W2160405912 cites W4241189322 @default.
• W2160405912 cites W4293247451 @default.
• W2160405912 cites W971000410 @default.
• W2160405912 doi "https://doi.org/10.1016/s0002-9440(10)63475-x" @default.
• W2160405912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1868238" @default.
• W2160405912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12937157" @default.
• W2160405912 hasPublicationYear "2003" @default.
• W2160405912 type Work @default.
• W2160405912 sameAs 2160405912 @default.
• W2160405912 citedByCount "72" @default.
• W2160405912 countsByYear W21604059122012 @default.
• W2160405912 countsByYear W21604059122013 @default.
• W2160405912 countsByYear W21604059122014 @default.
• W2160405912 countsByYear W21604059122015 @default.
• W2160405912 countsByYear W21604059122016 @default.
• W2160405912 countsByYear W21604059122017 @default.
• W2160405912 countsByYear W21604059122018 @default.
• W2160405912 countsByYear W21604059122019 @default.
• W2160405912 countsByYear W21604059122021 @default.
• W2160405912 countsByYear W21604059122023 @default.
• W2160405912 crossrefType "journal-article" @default.
• W2160405912 hasAuthorship W2160405912A5030545609 @default.
• W2160405912 hasAuthorship W2160405912A5046186733 @default.
• W2160405912 hasAuthorship W2160405912A5087838903 @default.
• W2160405912 hasBestOaLocation W21604059122 @default.
• W2160405912 hasConcept C104317684 @default.
• W2160405912 hasConcept C11960822 @default.
• W2160405912 hasConcept C126322002 @default.
• W2160405912 hasConcept C134018914 @default.
• W2160405912 hasConcept C163235415 @default.
• W2160405912 hasConcept C185592680 @default.
• W2160405912 hasConcept C199217515 @default.
• W2160405912 hasConcept C2777622882 @default.
• W2160405912 hasConcept C2778524494 @default.
• W2160405912 hasConcept C2778827303 @default.
• W2160405912 hasConcept C2780161600 @default.
• W2160405912 hasConcept C3020139451 @default.

• next