FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160408875> ?p ?o ?g. }

• W2160408875 endingPage "1750" @default.
• W2160408875 startingPage "1744" @default.
• W2160408875 abstract "During root formation, Smad-4 plays a key role during the epithelial–mesenchymal interactions and the Hertwig's epithelial root sheath (HERS) apical proliferation. The root formation and eruption of rat molars is impeded by alendronate treatment due to the inhibition of bone resortion by this drug. The present study aimed to examine the structures affected in the developing root and immunodetect the presence of Smad-4 in rats treated with alendronate. Newborn Wistar rats were daily injected 2.5 mg/kg alendronate (ALN) during 9, 12 and 30 days. The controls (CON) were injected with saline. The maxillae were fixed and embedded in paraffin or Spurr resin. Paraffin sections were incubated in Smad-4 antibody that was labelled with DAB. The ultrathin sections were examined in a transmission electron microscope. In ALN, a short portion of root dentine was formed; the epithelial diaphragm (ED) and the dental follicle (DF) were disorganized by the contact of bone trabeculae. The (CON) molar roots developed normally. Smad-4 labelling was detected in the cytoplasm of fibroblasts and cementoblasts adjacent to the cementum in CON; in ALN group, few ED cells presented weak immunolabelling. Ultrastructurally, the ED and DF appeared disrupted due to the presence of thin bone trabeculae between its cells. It resulted in the lack of apical proliferation of HERS and, consequently, arrest of root formation. The immunodetection of Smad-4 in the DF cells of ALN specimens indicates that the signalling for the differentiation of these cells into cementum-forming fibroblasts and cementoblasts occurs, despite the impairment of root elongation." @default.
• W2160408875 created "2016-06-24" @default.
• W2160408875 creator A5020792072 @default.
• W2160408875 creator A5028258622 @default.
• W2160408875 creator A5032850501 @default.
• W2160408875 creator A5035503672 @default.
• W2160408875 creator A5046418215 @default.
• W2160408875 date "2013-11-01" @default.
• W2160408875 modified "2023-10-17" @default.
• W2160408875 title "Immunolocalization of Smad-4 in developing molar roots of alendronate-treated rats" @default.
• W2160408875 cites W1969649680 @default.
• W2160408875 cites W1982733281 @default.
• W2160408875 cites W1994023699 @default.
• W2160408875 cites W2002642962 @default.
• W2160408875 cites W2003887022 @default.
• W2160408875 cites W2005128372 @default.
• W2160408875 cites W2028435671 @default.
• W2160408875 cites W2033872292 @default.
• W2160408875 cites W2047041610 @default.
• W2160408875 cites W2055351427 @default.
• W2160408875 cites W2056145075 @default.
• W2160408875 cites W2064800356 @default.
• W2160408875 cites W2070347347 @default.
• W2160408875 cites W2074040064 @default.
• W2160408875 cites W2078738113 @default.
• W2160408875 cites W2098700462 @default.
• W2160408875 cites W2109538754 @default.
• W2160408875 cites W2118413209 @default.
• W2160408875 cites W2120956574 @default.
• W2160408875 cites W2125723268 @default.
• W2160408875 cites W2132650229 @default.
• W2160408875 cites W2133520462 @default.
• W2160408875 cites W2150070711 @default.
• W2160408875 cites W2154568166 @default.
• W2160408875 cites W2154629889 @default.
• W2160408875 cites W2163500609 @default.
• W2160408875 cites W2169884834 @default.
• W2160408875 doi "https://doi.org/10.1016/j.archoralbio.2013.06.002" @default.
• W2160408875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23827715" @default.
• W2160408875 hasPublicationYear "2013" @default.
• W2160408875 type Work @default.
• W2160408875 sameAs 2160408875 @default.
• W2160408875 citedByCount "5" @default.
• W2160408875 countsByYear W21604088752014 @default.
• W2160408875 countsByYear W21604088752017 @default.
• W2160408875 countsByYear W21604088752018 @default.
• W2160408875 countsByYear W21604088752023 @default.
• W2160408875 crossrefType "journal-article" @default.
• W2160408875 hasAuthorship W2160408875A5020792072 @default.
• W2160408875 hasAuthorship W2160408875A5028258622 @default.
• W2160408875 hasAuthorship W2160408875A5032850501 @default.
• W2160408875 hasAuthorship W2160408875A5035503672 @default.
• W2160408875 hasAuthorship W2160408875A5046418215 @default.
• W2160408875 hasBestOaLocation W21604088751 @default.
• W2160408875 hasConcept C105702510 @default.
• W2160408875 hasConcept C118131993 @default.
• W2160408875 hasConcept C142724271 @default.
• W2160408875 hasConcept C185592680 @default.
• W2160408875 hasConcept C198826908 @default.
• W2160408875 hasConcept C199343813 @default.
• W2160408875 hasConcept C202271784 @default.
• W2160408875 hasConcept C2776211174 @default.
• W2160408875 hasConcept C2777894202 @default.
• W2160408875 hasConcept C2779263046 @default.
• W2160408875 hasConcept C2781080636 @default.
• W2160408875 hasConcept C56302369 @default.
• W2160408875 hasConcept C71924100 @default.
• W2160408875 hasConcept C86803240 @default.
• W2160408875 hasConcept C95444343 @default.
• W2160408875 hasConceptScore W2160408875C105702510 @default.
• W2160408875 hasConceptScore W2160408875C118131993 @default.
• W2160408875 hasConceptScore W2160408875C142724271 @default.
• W2160408875 hasConceptScore W2160408875C185592680 @default.
• W2160408875 hasConceptScore W2160408875C198826908 @default.
• W2160408875 hasConceptScore W2160408875C199343813 @default.
• W2160408875 hasConceptScore W2160408875C202271784 @default.
• W2160408875 hasConceptScore W2160408875C2776211174 @default.
• W2160408875 hasConceptScore W2160408875C2777894202 @default.
• W2160408875 hasConceptScore W2160408875C2779263046 @default.
• W2160408875 hasConceptScore W2160408875C2781080636 @default.
• W2160408875 hasConceptScore W2160408875C56302369 @default.
• W2160408875 hasConceptScore W2160408875C71924100 @default.
• W2160408875 hasConceptScore W2160408875C86803240 @default.
• W2160408875 hasConceptScore W2160408875C95444343 @default.
• W2160408875 hasFunder F4320320997 @default.
• W2160408875 hasIssue "11" @default.
• W2160408875 hasLocation W21604088751 @default.
• W2160408875 hasLocation W21604088752 @default.
• W2160408875 hasOpenAccess W2160408875 @default.
• W2160408875 hasPrimaryLocation W21604088751 @default.
• W2160408875 hasRelatedWork W1987436734 @default.
• W2160408875 hasRelatedWork W2046660735 @default.
• W2160408875 hasRelatedWork W2055270494 @default.
• W2160408875 hasRelatedWork W2072146735 @default.
• W2160408875 hasRelatedWork W2084942376 @default.
• W2160408875 hasRelatedWork W2288331653 @default.
• W2160408875 hasRelatedWork W2343927674 @default.
• W2160408875 hasRelatedWork W2373010880 @default.

• next