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• W2160429819 endingPage "992" @default.
• W2160429819 startingPage "989" @default.
• W2160429819 abstract "Age-related macular degeneration (AMD), the most common cause of irreversible vision loss in individuals aged older than 50 years, is classified as either wet (neovascular) or dry (nonneovascular). Inherited variation in the complement factor H gene is a major risk factor for drusen in dry AMD. Here we report that a single-nucleotide polymorphism in the promoter region of HTRA1 , a serine protease gene on chromosome 10q26, is a major genetic risk factor for wet AMD. A whole-genome association mapping strategy was applied to a Chinese population, yielding a P value of <10 –11 . Individuals with the risk-associated genotype were estimated to have a likelihood of developing wet AMD 10 times that of individuals with the wild-type genotype." @default.
• W2160429819 created "2016-06-24" @default.
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• W2160429819 date "2006-11-10" @default.
• W2160429819 modified "2023-10-02" @default.
• W2160429819 title "<i>HTRA1</i> Promoter Polymorphism in Wet Age-Related Macular Degeneration" @default.
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• W2160429819 doi "https://doi.org/10.1126/science.1133807" @default.
• W2160429819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17053108" @default.
• W2160429819 hasPublicationYear "2006" @default.
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