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• W2160434296 abstract "Abstract Mitochondrial dysfunction is a global term used in the context of “unhealthy” mitochondria. In practical terms, mitochondria are extremely complex and highly adaptive in structure, chemical and enzymatic composition, subcellular distribution and functional interaction with other components of cells. Consequently, altered mitochondrial properties that are used in experimental studies as measures of mitochondrial dysfunction often provide little or no distinction between adaptive and maladaptive changes. This is especially a problem in terms of generation of oxidant species by mitochondria, wherein increased generation of superoxide anion radical (O ·) or hydrogen peroxide (H 2 O 2 ) is often considered synonymously with mitochondrial dysfunction. However, these oxidative species are signaling molecules in normal physiology so that a change in production or abundance is not a good criterion for mitochondrial dysfunction. In this review, we consider generation of reactive electrophiles and consequent modification of mitochondrial proteins as a means to define mitochondrial dysfunction. Accumulated evidence indicates that 4‐hydroxynonenal (HNE) modification of proteins reflects mitochondrial dysfunction and provides an operational criterion for experimental definition of mitochondrial dysfunction. Improved means to detect and quantify mitochondrial HNE‐protein adduct formation could allow its use for environmental healthrisk assessment. Furthermore, application of improved mass spectrometry‐based proteomic methods will lead to further understanding of the critical targets contributing to disease risk. Environ. Mol. Mutagen., 2010. © 2010 Wiley‐Liss, Inc." @default.
• W2160434296 created "2016-06-24" @default.
• W2160434296 creator A5035904189 @default.
• W2160434296 creator A5063473428 @default.
• W2160434296 date "2010-03-26" @default.
• W2160434296 modified "2023-10-16" @default.
• W2160434296 title "Reactive species and mitochondrial dysfunction: Mechanistic significance of 4‐hydroxynonenal" @default.
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• W2160434296 doi "https://doi.org/10.1002/em.20553" @default.
• W2160434296 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5906392" @default.
• W2160434296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20544880" @default.
• W2160434296 hasPublicationYear "2010" @default.
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