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- W2160455928 endingPage "1305" @default.
- W2160455928 startingPage "1291" @default.
- W2160455928 abstract "The malaria parasite Plasmodium falciparum is highly adapted to cope with the oxidative stress to which it is exposed during the erythrocytic stages of its life cycle. This includes the defence against oxidative insults arising from the parasite's metabolism of haemoglobin which results in the formation of reactive oxygen species and the release of toxic ferriprotoporphyrin IX. Central to the parasite's defences are superoxide dismutases and thioredoxin-dependent peroxidases; however, they lack catalase and glutathione peroxidases. The vital importance of the thioredoxin redox cycle (comprising NADPH, thioredoxin reductase and thioredoxin) is emphasized by the confirmation that thioredoxin reductase is essential for the survival of intraerythrocytic P. falciparum. The parasites also contain a fully functional glutathione redox system and the low-molecular-weight thiol glutathione is not only an important intracellular thiol redox buffer but also a cofactor for several redox active enzymes such as glutathione S-transferase and glutaredoxin. Recent findings have shown that in addition to these cytosolic redox systems the parasite also has an important mitochondrial antioxidant defence system and it is suggested that lipoic acid plays a pivotal part in defending the organelle from oxidative damage." @default.
- W2160455928 created "2016-06-24" @default.
- W2160455928 creator A5087971903 @default.
- W2160455928 date "2004-08-03" @default.
- W2160455928 modified "2023-10-18" @default.
- W2160455928 title "Redox and antioxidant systems of the malaria parasite Plasmodium falciparum" @default.
- W2160455928 cites W105275551 @default.
- W2160455928 cites W120509749 @default.
- W2160455928 cites W1489620726 @default.
- W2160455928 cites W1497881418 @default.
- W2160455928 cites W1502619923 @default.
- W2160455928 cites W1541322308 @default.
- W2160455928 cites W1590010999 @default.
- W2160455928 cites W179558722 @default.
- W2160455928 cites W1823950544 @default.
- W2160455928 cites W1917090889 @default.
- W2160455928 cites W1922669960 @default.
- W2160455928 cites W1963775811 @default.
- W2160455928 cites W1963957430 @default.
- W2160455928 cites W1966728645 @default.
- W2160455928 cites W1966825850 @default.
- W2160455928 cites W1966854071 @default.
- W2160455928 cites W1969180772 @default.
- W2160455928 cites W1971173704 @default.
- W2160455928 cites W1971730958 @default.
- W2160455928 cites W1972177048 @default.
- W2160455928 cites W1972748438 @default.
- W2160455928 cites W1973071825 @default.
- W2160455928 cites W1973393110 @default.
- W2160455928 cites W1975695039 @default.
- W2160455928 cites W1979230714 @default.
- W2160455928 cites W1979955102 @default.
- W2160455928 cites W1980548104 @default.
- W2160455928 cites W1983722360 @default.
- W2160455928 cites W1985376893 @default.
- W2160455928 cites W1989499492 @default.
- W2160455928 cites W1989953524 @default.
- W2160455928 cites W1989962182 @default.
- W2160455928 cites W1990201609 @default.
- W2160455928 cites W1990357292 @default.
- W2160455928 cites W1990545773 @default.
- W2160455928 cites W1991236015 @default.
- W2160455928 cites W1991542003 @default.
- W2160455928 cites W1992024372 @default.
- W2160455928 cites W1992390260 @default.
- W2160455928 cites W1994860086 @default.
- W2160455928 cites W1995054863 @default.
- W2160455928 cites W1997554053 @default.
- W2160455928 cites W1997824991 @default.
- W2160455928 cites W2001291724 @default.
- W2160455928 cites W2001828546 @default.
- W2160455928 cites W2002794726 @default.
- W2160455928 cites W2002897522 @default.
- W2160455928 cites W2003271897 @default.
- W2160455928 cites W2004759032 @default.
- W2160455928 cites W2005789396 @default.
- W2160455928 cites W2007416146 @default.
- W2160455928 cites W2009496755 @default.
- W2160455928 cites W2010943728 @default.
- W2160455928 cites W2011352331 @default.
- W2160455928 cites W2012288977 @default.
- W2160455928 cites W2014387796 @default.
- W2160455928 cites W2015675440 @default.
- W2160455928 cites W2016950428 @default.
- W2160455928 cites W2018244383 @default.
- W2160455928 cites W2018659476 @default.
- W2160455928 cites W2018789203 @default.
- W2160455928 cites W2019211309 @default.
- W2160455928 cites W2020735633 @default.
- W2160455928 cites W2021679245 @default.
- W2160455928 cites W2022283741 @default.
- W2160455928 cites W2022857214 @default.
- W2160455928 cites W2024072544 @default.
- W2160455928 cites W2028905108 @default.
- W2160455928 cites W2029144058 @default.
- W2160455928 cites W2030605166 @default.
- W2160455928 cites W2032119559 @default.
- W2160455928 cites W2033223075 @default.
- W2160455928 cites W2033721665 @default.
- W2160455928 cites W2034612846 @default.
- W2160455928 cites W2035796924 @default.
- W2160455928 cites W2037368509 @default.
- W2160455928 cites W2037837934 @default.
- W2160455928 cites W2037995844 @default.
- W2160455928 cites W2040694163 @default.
- W2160455928 cites W2042041984 @default.
- W2160455928 cites W2044808644 @default.
- W2160455928 cites W2045431209 @default.
- W2160455928 cites W2046291591 @default.
- W2160455928 cites W2048045416 @default.
- W2160455928 cites W2049168250 @default.
- W2160455928 cites W2049599513 @default.
- W2160455928 cites W2049775789 @default.
- W2160455928 cites W2050354457 @default.
- W2160455928 cites W2052977448 @default.
- W2160455928 cites W2054001413 @default.
- W2160455928 cites W2056039473 @default.
- W2160455928 cites W2059571377 @default.