FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160475087> ?p ?o ?g. }

• W2160475087 endingPage "423" @default.
• W2160475087 startingPage "410" @default.
• W2160475087 abstract "Dopamine D3 receptor (D3R)-selective compounds may be useful medications for cocaine dependence. In this study, we identified two novel arylamide phenylpiperazines, OS-3-106 and WW-III-55, as partial agonists at the D3R in the adenylyl cyclase inhibition assay. OS-3-106 and WW-III-55 have 115- and 862-fold D3R:D2 receptor (D2R) binding selectivity, respectively. We investigated their effects (0, 3, 5.6, or 10 mg/kg) on operant responding by using a multiple variable-interval (VI) 60-second schedule that alternated components with sucrose reinforcement and components with intravenous cocaine reinforcement (0.375 mg/kg). Additionally, we evaluated the effect of OS-3-106 (10 mg/kg) on the dose-response function of cocaine self-administration and the effect of WW-III-55 (0–5.6 mg/kg) on a progressive ratio schedule with either cocaine or sucrose reinforcement. Both compounds were also examined for effects on locomotion and yawning induced by a D3R agonist. OS-3-106 decreased cocaine and sucrose reinforcement rates, increased latency to first response for cocaine but not sucrose, and downshifted the cocaine self-administration dose-response function. WW-III-55 did not affect cocaine self-administration on the multiple-variable interval schedule, but it reduced cocaine and sucrose intake on the progressive ratio schedule. Both compounds reduced locomotion at doses that reduced responding, and both compounds attenuated yawning induced by low doses of 7-OH-DPAT (a D3R-mediated behavior), but neither affected yawning on the descending limb of the 7-OH-DPAT dose-response function (a D2R-mediated behavior). Therefore, both compounds blocked a D3R-mediated behavior. However, OS-3-106 was more effective in reducing cocaine self-administration. These findings support D3Rs, and possibly D2Rs, as targets for medications aimed at reducing the motivation to seek cocaine." @default.
• W2160475087 created "2016-06-24" @default.
• W2160475087 creator A5003454044 @default.
• W2160475087 creator A5013971949 @default.
• W2160475087 creator A5043008322 @default.
• W2160475087 creator A5059770390 @default.
• W2160475087 creator A5060141283 @default.
• W2160475087 creator A5066099093 @default.
• W2160475087 creator A5074669627 @default.
• W2160475087 creator A5078270885 @default.
• W2160475087 creator A5086499463 @default.
• W2160475087 date "2013-09-09" @default.
• W2160475087 modified "2023-09-27" @default.
• W2160475087 title "Reduction of Cocaine Self-Administration and D3 Receptor-Mediated Behavior by Two Novel Dopamine D3 Receptor-Selective Partial Agonists, OS-3-106 and WW-III-55" @default.
• W2160475087 cites W1481581387 @default.
• W2160475087 cites W1482965181 @default.
• W2160475087 cites W1491097823 @default.
• W2160475087 cites W1963562655 @default.
• W2160475087 cites W1965680724 @default.
• W2160475087 cites W1967823110 @default.
• W2160475087 cites W1968679588 @default.
• W2160475087 cites W1969949539 @default.
• W2160475087 cites W1975667546 @default.
• W2160475087 cites W1978441937 @default.
• W2160475087 cites W1978999141 @default.
• W2160475087 cites W1984727326 @default.
• W2160475087 cites W1985582613 @default.
• W2160475087 cites W1986269606 @default.
• W2160475087 cites W1987346819 @default.
• W2160475087 cites W1998176465 @default.
• W2160475087 cites W2004204508 @default.
• W2160475087 cites W2013431976 @default.
• W2160475087 cites W2016038749 @default.
• W2160475087 cites W2017578012 @default.
• W2160475087 cites W2020665253 @default.
• W2160475087 cites W2022741861 @default.
• W2160475087 cites W2024845495 @default.
• W2160475087 cites W2024895660 @default.
• W2160475087 cites W2032116291 @default.
• W2160475087 cites W2032955416 @default.
• W2160475087 cites W2034996573 @default.
• W2160475087 cites W2035980109 @default.
• W2160475087 cites W2036218676 @default.
• W2160475087 cites W2037457092 @default.
• W2160475087 cites W2038505533 @default.
• W2160475087 cites W2039209971 @default.
• W2160475087 cites W2057217590 @default.
• W2160475087 cites W2068845975 @default.
• W2160475087 cites W2070639484 @default.
• W2160475087 cites W2074607412 @default.
• W2160475087 cites W2074631079 @default.
• W2160475087 cites W2082216956 @default.
• W2160475087 cites W2106719141 @default.
• W2160475087 cites W2111894007 @default.
• W2160475087 cites W2114239792 @default.
• W2160475087 cites W2119097756 @default.
• W2160475087 cites W2133416571 @default.
• W2160475087 cites W2147493925 @default.
• W2160475087 cites W2148455827 @default.
• W2160475087 cites W2160786866 @default.
• W2160475087 cites W2167052462 @default.
• W2160475087 cites W2227683063 @default.
• W2160475087 cites W2322589228 @default.
• W2160475087 cites W2328414509 @default.
• W2160475087 cites W2333240002 @default.
• W2160475087 cites W2487705059 @default.
• W2160475087 doi "https://doi.org/10.1124/jpet.112.202911" @default.
• W2160475087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3807071" @default.
• W2160475087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24018640" @default.
• W2160475087 hasPublicationYear "2013" @default.
• W2160475087 type Work @default.
• W2160475087 sameAs 2160475087 @default.
• W2160475087 citedByCount "25" @default.
• W2160475087 countsByYear W21604750872014 @default.
• W2160475087 countsByYear W21604750872015 @default.
• W2160475087 countsByYear W21604750872016 @default.
• W2160475087 countsByYear W21604750872017 @default.
• W2160475087 countsByYear W21604750872018 @default.
• W2160475087 countsByYear W21604750872019 @default.
• W2160475087 countsByYear W21604750872020 @default.
• W2160475087 countsByYear W21604750872021 @default.
• W2160475087 countsByYear W21604750872022 @default.
• W2160475087 countsByYear W21604750872023 @default.
• W2160475087 crossrefType "journal-article" @default.
• W2160475087 hasAuthorship W2160475087A5003454044 @default.
• W2160475087 hasAuthorship W2160475087A5013971949 @default.
• W2160475087 hasAuthorship W2160475087A5043008322 @default.
• W2160475087 hasAuthorship W2160475087A5059770390 @default.
• W2160475087 hasAuthorship W2160475087A5060141283 @default.
• W2160475087 hasAuthorship W2160475087A5066099093 @default.
• W2160475087 hasAuthorship W2160475087A5074669627 @default.
• W2160475087 hasAuthorship W2160475087A5078270885 @default.
• W2160475087 hasAuthorship W2160475087A5086499463 @default.
• W2160475087 hasBestOaLocation W21604750872 @default.
• W2160475087 hasConcept C126322002 @default.
• W2160475087 hasConcept C134018914 @default.
• W2160475087 hasConcept C170493617 @default.
• W2160475087 hasConcept C185592680 @default.

• next