Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160485536> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2160485536 endingPage "230" @default.
- W2160485536 startingPage "221" @default.
- W2160485536 abstract "Experimental studies on the complex process of mutagenesis are conducted in the belief that they will increase our understanding of the effects of environmental agents on human populations. Cultured mammalian cells offer distinct advantages over other biological systems for studying this problem. Mutagenesis in cultured mammalian cells is unquestionably more relevant to man than are bacterial, fungal, or insect systems. At the same time, compared to whole-animal studies, cultured cells offer the advantage of ease of handling, low cost, and rapidity of assay. Mutation in cultured mammalian cells can be identified and measured at the phenotypic, protein, and DNA levels. Test systems have been developed to detect both gene and chromosome mutations. Direct evidence is available for true mutations occurring in mammalian cells, although some of the heritable variations could be epigenetic. It is now possible to identify the specific molecular alternations in mammalian cell mutants arising in vitro. The development of methods for the quantitation of mutation in cultured mammalian cells has been briefly considered in this presentation, particularly with reference to the choice of cell material, development of selective markers, and the various factors that affect quantitative measurement of mutations. Although notable progress has been made, much still remains to be learned to make these measurements more reliable. In applying the mammalian cell mutation assays for the screening of environmental mutagens, the choice of a system or systems should be based on their technical advantages and relevance to man. The basic parameters of the mutagen screening system must be well defined and controlled. The sensitivity for detection may be increased by the use of hypermutable cell strains. Appropriate statistical models to account for various sources of variability and the choice of statistical methods for the analysis of data are important considerations in screening environmental mutagens and carcinogens." @default.
- W2160485536 created "2016-06-24" @default.
- W2160485536 creator A5049296315 @default.
- W2160485536 date "1983-06-01" @default.
- W2160485536 modified "2023-09-27" @default.
- W2160485536 title "MUTATION SYSTEMS IN CULTURED MAMMALIAN CELLS" @default.
- W2160485536 cites W1504396465 @default.
- W2160485536 cites W1528264894 @default.
- W2160485536 cites W1816746984 @default.
- W2160485536 cites W186830720 @default.
- W2160485536 cites W1963886849 @default.
- W2160485536 cites W1965877343 @default.
- W2160485536 cites W1972058038 @default.
- W2160485536 cites W1983478738 @default.
- W2160485536 cites W1994147983 @default.
- W2160485536 cites W1997397398 @default.
- W2160485536 cites W2003169843 @default.
- W2160485536 cites W2004276078 @default.
- W2160485536 cites W2008563472 @default.
- W2160485536 cites W2014206927 @default.
- W2160485536 cites W2015554258 @default.
- W2160485536 cites W2021710350 @default.
- W2160485536 cites W2023796599 @default.
- W2160485536 cites W2023878236 @default.
- W2160485536 cites W2024293482 @default.
- W2160485536 cites W2040830091 @default.
- W2160485536 cites W2043317995 @default.
- W2160485536 cites W2048150355 @default.
- W2160485536 cites W2054631939 @default.
- W2160485536 cites W2060262724 @default.
- W2160485536 cites W2067105349 @default.
- W2160485536 cites W2073155396 @default.
- W2160485536 cites W2075812506 @default.
- W2160485536 cites W4366064882 @default.
- W2160485536 cites W51776240 @default.
- W2160485536 doi "https://doi.org/10.1111/j.1749-6632.1983.tb47827.x" @default.
- W2160485536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6349476" @default.
- W2160485536 hasPublicationYear "1983" @default.
- W2160485536 type Work @default.
- W2160485536 sameAs 2160485536 @default.
- W2160485536 citedByCount "3" @default.
- W2160485536 crossrefType "journal-article" @default.
- W2160485536 hasAuthorship W2160485536A5049296315 @default.
- W2160485536 hasBestOaLocation W21604855362 @default.
- W2160485536 hasConcept C104317684 @default.
- W2160485536 hasConcept C127716648 @default.
- W2160485536 hasConcept C143065580 @default.
- W2160485536 hasConcept C16318435 @default.
- W2160485536 hasConcept C2994225774 @default.
- W2160485536 hasConcept C41091548 @default.
- W2160485536 hasConcept C501734568 @default.
- W2160485536 hasConcept C54355233 @default.
- W2160485536 hasConcept C70721500 @default.
- W2160485536 hasConcept C86803240 @default.
- W2160485536 hasConcept C95444343 @default.
- W2160485536 hasConceptScore W2160485536C104317684 @default.
- W2160485536 hasConceptScore W2160485536C127716648 @default.
- W2160485536 hasConceptScore W2160485536C143065580 @default.
- W2160485536 hasConceptScore W2160485536C16318435 @default.
- W2160485536 hasConceptScore W2160485536C2994225774 @default.
- W2160485536 hasConceptScore W2160485536C41091548 @default.
- W2160485536 hasConceptScore W2160485536C501734568 @default.
- W2160485536 hasConceptScore W2160485536C54355233 @default.
- W2160485536 hasConceptScore W2160485536C70721500 @default.
- W2160485536 hasConceptScore W2160485536C86803240 @default.
- W2160485536 hasConceptScore W2160485536C95444343 @default.
- W2160485536 hasIssue "1" @default.
- W2160485536 hasLocation W21604855361 @default.
- W2160485536 hasLocation W21604855362 @default.
- W2160485536 hasLocation W21604855363 @default.
- W2160485536 hasOpenAccess W2160485536 @default.
- W2160485536 hasPrimaryLocation W21604855361 @default.
- W2160485536 hasRelatedWork W1530845363 @default.
- W2160485536 hasRelatedWork W188926022 @default.
- W2160485536 hasRelatedWork W1913380961 @default.
- W2160485536 hasRelatedWork W1972644491 @default.
- W2160485536 hasRelatedWork W2009647017 @default.
- W2160485536 hasRelatedWork W2030205636 @default.
- W2160485536 hasRelatedWork W2034103052 @default.
- W2160485536 hasRelatedWork W2050054436 @default.
- W2160485536 hasRelatedWork W2143066563 @default.
- W2160485536 hasRelatedWork W2377600730 @default.
- W2160485536 hasVolume "407" @default.
- W2160485536 isParatext "false" @default.
- W2160485536 isRetracted "false" @default.
- W2160485536 magId "2160485536" @default.
- W2160485536 workType "article" @default.