Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160490375> ?p ?o ?g. }
- W2160490375 endingPage "264" @default.
- W2160490375 startingPage "252" @default.
- W2160490375 abstract "The membrane-anchored matrix metalloproteinase-regulator RECK is often downregulated in various types of cancers; the levels of residual RECK in resected tumors often correlate with better prognosis. Forced expression of RECK in cancer cells suppresses tumor angiogenesis, invasion, and metastasis in xenograft models. RECK is therefore a promising marker for benignancy and a potential effector in cancer therapy. We established a cell line containing two transgene systems: (1) the secreted alkaline phosphatase (SEAP) gene fused to Reck promoter and (2) the HRAS(12V) oncogene driven by the Tet-off promoter system. This cell line exhibits transformed phenotype in regular medium and flat morphology with increased SEAP activity in the presence of doxycycline, allowing the assessment of RECK-inducing activity of chemicals in the contexts of both transformed and untransformed cells. Our pilot experiments with 880 known bioactive compounds detected 34 compounds that activate RECK promoter; among these, 10 were authentic anticancer drugs. Four selected compounds up-regulated endogenous RECK protein in several human cancer cell lines. The top-ranking compound, disulfiram, strongly suppressed spontaneous lung-metastasis of human fibrosarcoma cells in nude mice. Our data demonstrate the value of this screen in discovering effective cancer therapeutics." @default.
- W2160490375 created "2016-06-24" @default.
- W2160490375 creator A5014338402 @default.
- W2160490375 creator A5015259799 @default.
- W2160490375 creator A5016959425 @default.
- W2160490375 creator A5040884081 @default.
- W2160490375 creator A5046715170 @default.
- W2160490375 creator A5058229806 @default.
- W2160490375 creator A5062846622 @default.
- W2160490375 creator A5067430862 @default.
- W2160490375 creator A5073353717 @default.
- W2160490375 creator A5078263403 @default.
- W2160490375 creator A5091839970 @default.
- W2160490375 date "2010-08-06" @default.
- W2160490375 modified "2023-09-30" @default.
- W2160490375 title "A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs" @default.
- W2160490375 cites W1966498112 @default.
- W2160490375 cites W1972779889 @default.
- W2160490375 cites W1977594275 @default.
- W2160490375 cites W1983801175 @default.
- W2160490375 cites W1984483611 @default.
- W2160490375 cites W1985760249 @default.
- W2160490375 cites W1990574061 @default.
- W2160490375 cites W2007444742 @default.
- W2160490375 cites W2009080781 @default.
- W2160490375 cites W2012047645 @default.
- W2160490375 cites W2013229653 @default.
- W2160490375 cites W2014622954 @default.
- W2160490375 cites W2017502530 @default.
- W2160490375 cites W2021762355 @default.
- W2160490375 cites W2025840341 @default.
- W2160490375 cites W2031212465 @default.
- W2160490375 cites W2036180531 @default.
- W2160490375 cites W2040400232 @default.
- W2160490375 cites W2041101693 @default.
- W2160490375 cites W2042198997 @default.
- W2160490375 cites W2051143932 @default.
- W2160490375 cites W2052907252 @default.
- W2160490375 cites W2054549064 @default.
- W2160490375 cites W2061050600 @default.
- W2160490375 cites W2064023379 @default.
- W2160490375 cites W2064122350 @default.
- W2160490375 cites W2070358111 @default.
- W2160490375 cites W2072911310 @default.
- W2160490375 cites W2076222750 @default.
- W2160490375 cites W2081923855 @default.
- W2160490375 cites W2084541153 @default.
- W2160490375 cites W2084596562 @default.
- W2160490375 cites W2091477263 @default.
- W2160490375 cites W2092296830 @default.
- W2160490375 cites W2093921289 @default.
- W2160490375 cites W2096466633 @default.
- W2160490375 cites W2097806194 @default.
- W2160490375 cites W2102838769 @default.
- W2160490375 cites W2128049766 @default.
- W2160490375 cites W2129778797 @default.
- W2160490375 cites W2150435290 @default.
- W2160490375 cites W2152667145 @default.
- W2160490375 cites W2156873394 @default.
- W2160490375 cites W2157215186 @default.
- W2160490375 cites W297455914 @default.
- W2160490375 cites W995739795 @default.
- W2160490375 doi "https://doi.org/10.18632/oncotarget.136" @default.
- W2160490375 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3248105" @default.
- W2160490375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21304177" @default.
- W2160490375 hasPublicationYear "2010" @default.
- W2160490375 type Work @default.
- W2160490375 sameAs 2160490375 @default.
- W2160490375 citedByCount "29" @default.
- W2160490375 countsByYear W21604903752012 @default.
- W2160490375 countsByYear W21604903752013 @default.
- W2160490375 countsByYear W21604903752014 @default.
- W2160490375 countsByYear W21604903752015 @default.
- W2160490375 countsByYear W21604903752016 @default.
- W2160490375 countsByYear W21604903752017 @default.
- W2160490375 countsByYear W21604903752019 @default.
- W2160490375 countsByYear W21604903752020 @default.
- W2160490375 countsByYear W21604903752021 @default.
- W2160490375 countsByYear W21604903752022 @default.
- W2160490375 countsByYear W21604903752023 @default.
- W2160490375 crossrefType "journal-article" @default.
- W2160490375 hasAuthorship W2160490375A5014338402 @default.
- W2160490375 hasAuthorship W2160490375A5015259799 @default.
- W2160490375 hasAuthorship W2160490375A5016959425 @default.
- W2160490375 hasAuthorship W2160490375A5040884081 @default.
- W2160490375 hasAuthorship W2160490375A5046715170 @default.
- W2160490375 hasAuthorship W2160490375A5058229806 @default.
- W2160490375 hasAuthorship W2160490375A5062846622 @default.
- W2160490375 hasAuthorship W2160490375A5067430862 @default.
- W2160490375 hasAuthorship W2160490375A5073353717 @default.
- W2160490375 hasAuthorship W2160490375A5078263403 @default.
- W2160490375 hasAuthorship W2160490375A5091839970 @default.
- W2160490375 hasBestOaLocation W21604903751 @default.
- W2160490375 hasConcept C121608353 @default.
- W2160490375 hasConcept C2777751087 @default.
- W2160490375 hasConcept C2778025950 @default.
- W2160490375 hasConcept C2779013556 @default.
- W2160490375 hasConcept C2780394083 @default.