FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160496747> ?p ?o ?g. }

• W2160496747 endingPage "5567" @default.
• W2160496747 startingPage "5560" @default.
• W2160496747 abstract "Abstract At the temperature of its flea vector (∼20–30°C), the causative agent of plague, Yersinia pestis, expresses a profile of genes distinct from those expressed in a mammalian host (37°C). When dendritic cells (DC) are exposed to Y. pestis grown at 26°C (Y. pestis-26°), they secrete copious amounts of IL-12p40 homodimer (IL-12(p40)2). In contrast, when DCs are exposed to Y. pestis grown at 37°C (Y. pestis-37°), they transcribe very little IL-12p40, which is secreted as IL-12p40 monomer (IL-12p40). Y. pestis-26° also induces migration of DCs to the homeostatic chemokine CCL19, whereas Y. pestis-37° does not; migratory DCs are positive for IL-12p40 transcription and secrete mostly IL-12(p40)2; DCs lacking IL-12p40 do not migrate. Expression of acyltransferase LpxL from Escherichia coli in Y. pestis-37° results in the production of a hexa-acylated lipid A, also seen in Y. pestis-26°, rather than tetra-acylated lipid A normally seen in Y. pestis-37°. The LpxL-expressing Y. pestis-37° promotes DC IL-12(p40)2 production and induction of DC migration. In addition, absence of TLR4 ablates production of IL-12(p40)2 in DC exposed to Y. pestis-26°. The data demonstrate the molecular pathway by which Y. pestis evades induction of early DC activation as measured by migration and IL-12(p40)2 production." @default.
• W2160496747 created "2016-06-24" @default.
• W2160496747 creator A5011118746 @default.
• W2160496747 creator A5062279144 @default.
• W2160496747 creator A5066993086 @default.
• W2160496747 creator A5082894590 @default.
• W2160496747 creator A5083188118 @default.
• W2160496747 creator A5087535749 @default.
• W2160496747 date "2008-10-15" @default.
• W2160496747 modified "2023-10-16" @default.
• W2160496747 title "<i>Yersinia pestis</i> Evades TLR4-dependent Induction of IL-12(p40)2 by Dendritic Cells and Subsequent Cell Migration" @default.
• W2160496747 cites W1499048411 @default.
• W2160496747 cites W1559286577 @default.
• W2160496747 cites W1887152152 @default.
• W2160496747 cites W1978346502 @default.
• W2160496747 cites W1978926805 @default.
• W2160496747 cites W1990861039 @default.
• W2160496747 cites W1997490715 @default.
• W2160496747 cites W2022104546 @default.
• W2160496747 cites W2023650245 @default.
• W2160496747 cites W2029031008 @default.
• W2160496747 cites W2030598858 @default.
• W2160496747 cites W2031799130 @default.
• W2160496747 cites W2032786252 @default.
• W2160496747 cites W2036767516 @default.
• W2160496747 cites W2081487051 @default.
• W2160496747 cites W2085414634 @default.
• W2160496747 cites W2092235636 @default.
• W2160496747 cites W2098907119 @default.
• W2160496747 cites W2101363646 @default.
• W2160496747 cites W2106687873 @default.
• W2160496747 cites W2116513121 @default.
• W2160496747 cites W2118488619 @default.
• W2160496747 cites W2120412245 @default.
• W2160496747 cites W2126147958 @default.
• W2160496747 cites W2129280927 @default.
• W2160496747 cites W2131558932 @default.
• W2160496747 cites W2132032241 @default.
• W2160496747 cites W2145638464 @default.
• W2160496747 cites W2145912774 @default.
• W2160496747 cites W2149057253 @default.
• W2160496747 cites W2150108816 @default.
• W2160496747 cites W2155184228 @default.
• W2160496747 cites W2159866361 @default.
• W2160496747 cites W2161243122 @default.
• W2160496747 cites W2165455201 @default.
• W2160496747 cites W2167534140 @default.
• W2160496747 cites W2167681235 @default.
• W2160496747 cites W2168819347 @default.
• W2160496747 cites W2169390260 @default.
• W2160496747 cites W2169879234 @default.
• W2160496747 cites W2253197064 @default.
• W2160496747 doi "https://doi.org/10.4049/jimmunol.181.8.5560" @default.
• W2160496747 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2640496" @default.
• W2160496747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18832714" @default.
• W2160496747 hasPublicationYear "2008" @default.
• W2160496747 type Work @default.
• W2160496747 sameAs 2160496747 @default.
• W2160496747 citedByCount "38" @default.
• W2160496747 countsByYear W21604967472012 @default.
• W2160496747 countsByYear W21604967472013 @default.
• W2160496747 countsByYear W21604967472014 @default.
• W2160496747 countsByYear W21604967472015 @default.
• W2160496747 countsByYear W21604967472016 @default.
• W2160496747 countsByYear W21604967472019 @default.
• W2160496747 countsByYear W21604967472020 @default.
• W2160496747 countsByYear W21604967472021 @default.
• W2160496747 countsByYear W21604967472023 @default.
• W2160496747 crossrefType "journal-article" @default.
• W2160496747 hasAuthorship W2160496747A5011118746 @default.
• W2160496747 hasAuthorship W2160496747A5062279144 @default.
• W2160496747 hasAuthorship W2160496747A5066993086 @default.
• W2160496747 hasAuthorship W2160496747A5082894590 @default.
• W2160496747 hasAuthorship W2160496747A5083188118 @default.
• W2160496747 hasAuthorship W2160496747A5087535749 @default.
• W2160496747 hasBestOaLocation W21604967471 @default.
• W2160496747 hasConcept C104317684 @default.
• W2160496747 hasConcept C13373296 @default.
• W2160496747 hasConcept C153911025 @default.
• W2160496747 hasConcept C203014093 @default.
• W2160496747 hasConcept C2776090121 @default.
• W2160496747 hasConcept C2777353990 @default.
• W2160496747 hasConcept C2778170410 @default.
• W2160496747 hasConcept C2778222588 @default.
• W2160496747 hasConcept C49039625 @default.
• W2160496747 hasConcept C55493867 @default.
• W2160496747 hasConcept C60987743 @default.
• W2160496747 hasConcept C86803240 @default.
• W2160496747 hasConcept C8891405 @default.
• W2160496747 hasConcept C89423630 @default.
• W2160496747 hasConcept C95444343 @default.
• W2160496747 hasConceptScore W2160496747C104317684 @default.
• W2160496747 hasConceptScore W2160496747C13373296 @default.
• W2160496747 hasConceptScore W2160496747C153911025 @default.
• W2160496747 hasConceptScore W2160496747C203014093 @default.
• W2160496747 hasConceptScore W2160496747C2776090121 @default.
• W2160496747 hasConceptScore W2160496747C2777353990 @default.
• W2160496747 hasConceptScore W2160496747C2778170410 @default.

• next