Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160532128> ?p ?o ?g. }
- W2160532128 endingPage "752" @default.
- W2160532128 startingPage "745" @default.
- W2160532128 abstract "We evaluated in vivo the effect of aging on the sigma(1) receptors in the monkey brain by the quantitative analysis of the binding of [11C]SA4503 to sigma(1) receptors with positron emission tomography. Based on a three-compartment model, the influx rate constant K(1) of [11C]SA4503 from plasma to brain across the blood-brain barrier in all 10 regions investigated became smaller in the aged monkeys (20-28 years old, n=5) than in the young adult monkeys (4-8 years old, n=5), but the reduction was not significant due to the individual differences. On the other hand, the binding potential, which was calculated as the ratio of the association rate constant k(3) to the dissociation rate constant k(4) for the binding of [11C]SA4503 to sigma(1) receptors in the brain, significantly increased in nine of the brain regions of the aged monkeys to the 160-210% levels of the young monkeys. We concluded that the sigma(1) receptor binding sites increased in the aging process of the monkey brain." @default.
- W2160532128 created "2016-06-24" @default.
- W2160532128 creator A5000509868 @default.
- W2160532128 creator A5011325858 @default.
- W2160532128 creator A5038010166 @default.
- W2160532128 creator A5043811211 @default.
- W2160532128 creator A5054074865 @default.
- W2160532128 creator A5059414275 @default.
- W2160532128 creator A5064366813 @default.
- W2160532128 creator A5064403117 @default.
- W2160532128 creator A5070077485 @default.
- W2160532128 creator A5070206132 @default.
- W2160532128 creator A5074027917 @default.
- W2160532128 date "2003-09-01" @default.
- W2160532128 modified "2023-10-06" @default.
- W2160532128 title "An increase of sigma1 receptors in the aged monkey brain" @default.
- W2160532128 cites W135531847 @default.
- W2160532128 cites W1538842286 @default.
- W2160532128 cites W164135422 @default.
- W2160532128 cites W1966931256 @default.
- W2160532128 cites W1972923832 @default.
- W2160532128 cites W1976698562 @default.
- W2160532128 cites W1978551290 @default.
- W2160532128 cites W1982612223 @default.
- W2160532128 cites W1982748830 @default.
- W2160532128 cites W1983721896 @default.
- W2160532128 cites W1985156573 @default.
- W2160532128 cites W1990326461 @default.
- W2160532128 cites W1995367798 @default.
- W2160532128 cites W2002850210 @default.
- W2160532128 cites W2003532781 @default.
- W2160532128 cites W2011985417 @default.
- W2160532128 cites W2012298500 @default.
- W2160532128 cites W2013164642 @default.
- W2160532128 cites W2014582815 @default.
- W2160532128 cites W2017051927 @default.
- W2160532128 cites W2021583585 @default.
- W2160532128 cites W2031211058 @default.
- W2160532128 cites W2033857032 @default.
- W2160532128 cites W2035188344 @default.
- W2160532128 cites W2040326898 @default.
- W2160532128 cites W2045509002 @default.
- W2160532128 cites W2046877633 @default.
- W2160532128 cites W2049200205 @default.
- W2160532128 cites W2053692618 @default.
- W2160532128 cites W2054107976 @default.
- W2160532128 cites W2057986474 @default.
- W2160532128 cites W2058350561 @default.
- W2160532128 cites W2068515553 @default.
- W2160532128 cites W2068622285 @default.
- W2160532128 cites W2070201437 @default.
- W2160532128 cites W2070360696 @default.
- W2160532128 cites W2073061978 @default.
- W2160532128 cites W2073787944 @default.
- W2160532128 cites W2079975721 @default.
- W2160532128 cites W2082199306 @default.
- W2160532128 cites W2082905508 @default.
- W2160532128 cites W2083149867 @default.
- W2160532128 cites W2083280262 @default.
- W2160532128 cites W2088982959 @default.
- W2160532128 cites W2126815463 @default.
- W2160532128 cites W2127005038 @default.
- W2160532128 cites W2127749802 @default.
- W2160532128 cites W2135072521 @default.
- W2160532128 cites W2138299620 @default.
- W2160532128 cites W278711765 @default.
- W2160532128 cites W2915208184 @default.
- W2160532128 cites W4245922855 @default.
- W2160532128 doi "https://doi.org/10.1016/s0197-4580(02)00152-5" @default.
- W2160532128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12885582" @default.
- W2160532128 hasPublicationYear "2003" @default.
- W2160532128 type Work @default.
- W2160532128 sameAs 2160532128 @default.
- W2160532128 citedByCount "50" @default.
- W2160532128 countsByYear W21605321282012 @default.
- W2160532128 countsByYear W21605321282013 @default.
- W2160532128 countsByYear W21605321282014 @default.
- W2160532128 countsByYear W21605321282015 @default.
- W2160532128 countsByYear W21605321282017 @default.
- W2160532128 countsByYear W21605321282019 @default.
- W2160532128 countsByYear W21605321282020 @default.
- W2160532128 countsByYear W21605321282021 @default.
- W2160532128 countsByYear W21605321282023 @default.
- W2160532128 crossrefType "journal-article" @default.
- W2160532128 hasAuthorship W2160532128A5000509868 @default.
- W2160532128 hasAuthorship W2160532128A5011325858 @default.
- W2160532128 hasAuthorship W2160532128A5038010166 @default.
- W2160532128 hasAuthorship W2160532128A5043811211 @default.
- W2160532128 hasAuthorship W2160532128A5054074865 @default.
- W2160532128 hasAuthorship W2160532128A5059414275 @default.
- W2160532128 hasAuthorship W2160532128A5064366813 @default.
- W2160532128 hasAuthorship W2160532128A5064403117 @default.
- W2160532128 hasAuthorship W2160532128A5070077485 @default.
- W2160532128 hasAuthorship W2160532128A5070206132 @default.
- W2160532128 hasAuthorship W2160532128A5074027917 @default.
- W2160532128 hasConcept C121332964 @default.
- W2160532128 hasConcept C126322002 @default.
- W2160532128 hasConcept C134018914 @default.