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- W2160534705 endingPage "108" @default.
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- W2160534705 abstract "Glycogen synthase kinase-3 (GSK-3), a member of the serine/threonine kinase family was first identified as an inhibitor of the metabolic enzyme glycogen synthase and is now accepted as a widely influential enzyme responsible for many intracellular regulatory mechanisms with over 50 known substrates characterized. There are two mammalian GSK-3 isoforms encoded by separate genes: GSK-3a and GSK- 3β with high structural homology. Both GSK-3β and GSK-3β are widely expressed in many tissues with the highest levels in the brain and their functions are generally considered to be indistinguishable. Unlike many other protein kinases, GSK-3 is constitutively dephosphorylated and active in resting cells. Phosphorylation of GSK-3 by other protein kinases such as PKA (Protein kinase A), AKT (Protein kinase B) and PKC (Protein kinase C) inhibits its activity. Today a growing body of evidence strongly suggests that increased GSK-3 activity is involved in the development of schizophrenia and mood disorders such as bipolar disorder, major depression and hyperactivity associated disorders. Thus, inhibition of overactive GSK-3 has become a promising target in the treatment of these psychiatric disorders. Herein we will briefly discuss the underlying mechanisms related to how GSK-3 is thought to participate in such diseases and will give examples of clinically important treatments that have a role in GSK-3 regulation." @default.
- W2160534705 created "2016-06-24" @default.
- W2160534705 creator A5003032584 @default.
- W2160534705 creator A5018364813 @default.
- W2160534705 creator A5053637049 @default.
- W2160534705 date "2014-03-01" @default.
- W2160534705 modified "2023-10-14" @default.
- W2160534705 title "Regulation of GSK-3 Activity as A Shared Mechanism in Psychiatric Disorders" @default.
- W2160534705 cites W1485363052 @default.
- W2160534705 cites W1488072553 @default.
- W2160534705 cites W1575385540 @default.
- W2160534705 cites W1758789982 @default.
- W2160534705 cites W1857269611 @default.
- W2160534705 cites W1963561816 @default.
- W2160534705 cites W1963600261 @default.
- W2160534705 cites W1964021320 @default.
- W2160534705 cites W1964597381 @default.
- W2160534705 cites W1964799699 @default.
- W2160534705 cites W1966175522 @default.
- W2160534705 cites W1967282380 @default.
- W2160534705 cites W1968213313 @default.
- W2160534705 cites W1968570162 @default.
- W2160534705 cites W1970777708 @default.
- W2160534705 cites W1971676848 @default.
- W2160534705 cites W1972343960 @default.
- W2160534705 cites W1974369164 @default.
- W2160534705 cites W1975257189 @default.
- W2160534705 cites W1979686167 @default.
- W2160534705 cites W1979777611 @default.
- W2160534705 cites W1979993283 @default.
- W2160534705 cites W1980167198 @default.
- W2160534705 cites W1981201938 @default.
- W2160534705 cites W1983055247 @default.
- W2160534705 cites W1985438873 @default.
- W2160534705 cites W1986185847 @default.
- W2160534705 cites W1991871366 @default.
- W2160534705 cites W1992529363 @default.
- W2160534705 cites W1993374921 @default.
- W2160534705 cites W1993796910 @default.
- W2160534705 cites W1995120027 @default.
- W2160534705 cites W1995540460 @default.
- W2160534705 cites W1998772348 @default.
- W2160534705 cites W1999080838 @default.
- W2160534705 cites W2006514811 @default.
- W2160534705 cites W2013316180 @default.
- W2160534705 cites W2014820398 @default.
- W2160534705 cites W2015472023 @default.
- W2160534705 cites W2017537754 @default.
- W2160534705 cites W2018328223 @default.
- W2160534705 cites W2022309233 @default.
- W2160534705 cites W2024493236 @default.
- W2160534705 cites W2028418645 @default.
- W2160534705 cites W2028494426 @default.
- W2160534705 cites W2029915913 @default.
- W2160534705 cites W2031329056 @default.
- W2160534705 cites W2033676408 @default.
- W2160534705 cites W2035603072 @default.
- W2160534705 cites W2036300535 @default.
- W2160534705 cites W2043012035 @default.
- W2160534705 cites W2043283741 @default.
- W2160534705 cites W2043606146 @default.
- W2160534705 cites W2047403745 @default.
- W2160534705 cites W2048062717 @default.
- W2160534705 cites W2049408722 @default.
- W2160534705 cites W2051110479 @default.
- W2160534705 cites W2051788298 @default.
- W2160534705 cites W2051811808 @default.
- W2160534705 cites W2052142284 @default.
- W2160534705 cites W2054492621 @default.
- W2160534705 cites W2058138221 @default.
- W2160534705 cites W2061088962 @default.
- W2160534705 cites W2061120947 @default.
- W2160534705 cites W2062244711 @default.
- W2160534705 cites W2066497759 @default.
- W2160534705 cites W2067592930 @default.
- W2160534705 cites W2068579398 @default.
- W2160534705 cites W2074258143 @default.
- W2160534705 cites W2074883812 @default.
- W2160534705 cites W2076403167 @default.
- W2160534705 cites W2077767624 @default.
- W2160534705 cites W2094531953 @default.
- W2160534705 cites W2097822805 @default.
- W2160534705 cites W2101948750 @default.
- W2160534705 cites W2108569388 @default.
- W2160534705 cites W2120071240 @default.
- W2160534705 cites W2131863923 @default.
- W2160534705 cites W2133144408 @default.
- W2160534705 cites W2133627256 @default.
- W2160534705 cites W2134773980 @default.
- W2160534705 cites W2135772494 @default.
- W2160534705 cites W2140864873 @default.
- W2160534705 cites W2158321076 @default.
- W2160534705 cites W2163224933 @default.
- W2160534705 cites W2163499365 @default.
- W2160534705 cites W2167088399 @default.
- W2160534705 cites W2167928721 @default.
- W2160534705 doi "https://doi.org/10.5455/bcp.20140317063255" @default.
- W2160534705 hasPublicationYear "2014" @default.