FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160544094> ?p ?o ?g. }

• W2160544094 abstract "Tauopathies are characterized by intracellular deposition of the microtubule-associated protein tau as filamentous aggregates. The rTg4510 mouse conditionally expresses mutant human tau protein in various forebrain areas under the Tet-off expression system. Mice develop neurofibrillary tangles, with significant neuronal loss and cognitive deficits by 6 months of age. Previous behavioral and biochemical work has linked the expression and aggregates of mutant tau to functional impairments. The present work used manganese-enhanced magnetic resonance imaging (MEMRI) to investigate basal levels of brain activity in the rTg4510 and control mice.Our results show an unmistakable curtailment of neural activity in the amygdala and hippocampus, two regions known for their role in memory formation, but not the cortex, cerebellum, striatum and hypothalamus in tau expressing mice.Behavioral impairments associated with changes in activity in these areas may correspond to age progressive mutant tau(P301L)-induced neurodegeneration." @default.
• W2160544094 created "2016-06-24" @default.
• W2160544094 creator A5001609822 @default.
• W2160544094 creator A5002825040 @default.
• W2160544094 creator A5013804286 @default.
• W2160544094 creator A5018231245 @default.
• W2160544094 creator A5051925093 @default.
• W2160544094 creator A5060370775 @default.
• W2160544094 creator A5075792942 @default.
• W2160544094 creator A5085217109 @default.
• W2160544094 date "2013-02-04" @default.
• W2160544094 modified "2023-09-27" @default.
• W2160544094 title "In vivo functional brain mapping in a conditional mouse model of human tauopathy (taup301l) reveals reduced neural activity in memory formation structures" @default.
• W2160544094 cites W1480786153 @default.
• W2160544094 cites W1516352634 @default.
• W2160544094 cites W1839562273 @default.
• W2160544094 cites W1965709917 @default.
• W2160544094 cites W1975644693 @default.
• W2160544094 cites W1975707153 @default.
• W2160544094 cites W1978481914 @default.
• W2160544094 cites W1993943874 @default.
• W2160544094 cites W2002034943 @default.
• W2160544094 cites W2006080132 @default.
• W2160544094 cites W2013887112 @default.
• W2160544094 cites W2020135632 @default.
• W2160544094 cites W2035156043 @default.
• W2160544094 cites W2039487422 @default.
• W2160544094 cites W2053535174 @default.
• W2160544094 cites W2057249855 @default.
• W2160544094 cites W2066824053 @default.
• W2160544094 cites W2067267086 @default.
• W2160544094 cites W2068310001 @default.
• W2160544094 cites W2080050622 @default.
• W2160544094 cites W2088384294 @default.
• W2160544094 cites W2092885373 @default.
• W2160544094 cites W2093852116 @default.
• W2160544094 cites W2095365896 @default.
• W2160544094 cites W2100026237 @default.
• W2160544094 cites W2107804537 @default.
• W2160544094 cites W2109510473 @default.
• W2160544094 cites W2129932730 @default.
• W2160544094 cites W2135309154 @default.
• W2160544094 cites W2135448296 @default.
• W2160544094 cites W2135661040 @default.
• W2160544094 cites W2145440751 @default.
• W2160544094 cites W2147959494 @default.
• W2160544094 cites W2150771555 @default.
• W2160544094 cites W2157899039 @default.
• W2160544094 cites W2165298588 @default.
• W2160544094 cites W2165725890 @default.
• W2160544094 cites W2170725855 @default.
• W2160544094 cites W4235770099 @default.
• W2160544094 cites W4362221370 @default.
• W2160544094 cites W47608607 @default.
• W2160544094 doi "https://doi.org/10.1186/1750-1326-8-9" @default.
• W2160544094 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3579718" @default.
• W2160544094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23379588" @default.
• W2160544094 hasPublicationYear "2013" @default.
• W2160544094 type Work @default.
• W2160544094 sameAs 2160544094 @default.
• W2160544094 citedByCount "37" @default.
• W2160544094 countsByYear W21605440942013 @default.
• W2160544094 countsByYear W21605440942014 @default.
• W2160544094 countsByYear W21605440942015 @default.
• W2160544094 countsByYear W21605440942016 @default.
• W2160544094 countsByYear W21605440942017 @default.
• W2160544094 countsByYear W21605440942018 @default.
• W2160544094 countsByYear W21605440942019 @default.
• W2160544094 countsByYear W21605440942020 @default.
• W2160544094 countsByYear W21605440942021 @default.
• W2160544094 countsByYear W21605440942022 @default.
• W2160544094 countsByYear W21605440942023 @default.
• W2160544094 crossrefType "journal-article" @default.
• W2160544094 hasAuthorship W2160544094A5001609822 @default.
• W2160544094 hasAuthorship W2160544094A5002825040 @default.
• W2160544094 hasAuthorship W2160544094A5013804286 @default.
• W2160544094 hasAuthorship W2160544094A5018231245 @default.
• W2160544094 hasAuthorship W2160544094A5051925093 @default.
• W2160544094 hasAuthorship W2160544094A5060370775 @default.
• W2160544094 hasAuthorship W2160544094A5075792942 @default.
• W2160544094 hasAuthorship W2160544094A5085217109 @default.
• W2160544094 hasBestOaLocation W21605440941 @default.
• W2160544094 hasConcept C126322002 @default.
• W2160544094 hasConcept C15744967 @default.
• W2160544094 hasConcept C169760540 @default.
• W2160544094 hasConcept C2776287375 @default.
• W2160544094 hasConcept C2776925932 @default.
• W2160544094 hasConcept C2777739294 @default.
• W2160544094 hasConcept C2778187257 @default.
• W2160544094 hasConcept C2778670691 @default.
• W2160544094 hasConcept C2779134260 @default.
• W2160544094 hasConcept C2779652256 @default.
• W2160544094 hasConcept C2780062018 @default.
• W2160544094 hasConcept C2781161787 @default.
• W2160544094 hasConcept C502032728 @default.
• W2160544094 hasConcept C513476851 @default.
• W2160544094 hasConcept C529278444 @default.
• W2160544094 hasConcept C71924100 @default.
• W2160544094 hasConcept C74254510 @default.
• W2160544094 hasConcept C86803240 @default.

• next