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- W2160578796 abstract "The Pr60gag protein of the murine AIDS (MAIDS) defective virus promotes the proliferation of the infected target B cells and is responsible for inducing a severe immunodeficiency disease. Using the yeast two-hybrid system, we identified the SH3 domain of c-Abl as interacting with the proline-rich p12 domain of Pr60gag. The two proteins were shown to associate in vitro and in vivo in MAIDS virus-infected B cells. Overexpression of Pr60(gag) in these cells led to a detectable increase of the levels of c-Abl protein and to its translocation at the membrane. These results suggest that this viral protein serves as a docking site for signaling molecules and that c-Abl may be involved in the proliferation of infected B cells." @default.
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- W2160578796 date "1997-04-01" @default.
- W2160578796 modified "2023-10-16" @default.
- W2160578796 title "The murine AIDS virus Gag precursor protein binds to the SH3 domain of c-Abl" @default.
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- W2160578796 doi "https://doi.org/10.1128/jvi.71.4.2615-2620.1997" @default.
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