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• W2160590108 abstract "Serum amyloid A protein (SAA) surges 1,000-fold in the blood of acute-phase animals, and yet its function during these acute events remains unknown. We report herein that SAA stimulates a developmental program in cultured NRK-52E cells that culminates in differentiated and functional tubules that feature a proximal tubule phenotype. We also found strong SAA expression in states of tubule formation (in utero stage) and regeneration (recovery from ischemia-reperfusion injury). These data lend support to a novel view of a more localized renal acute-phase reaction, where renal SAA may act as a paracrine or autocrine molecule that promotes tubule formation during development and repair." @default.
• W2160590108 created "2016-06-24" @default.
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• W2160590108 date "2009-06-01" @default.
• W2160590108 modified "2023-10-13" @default.
• W2160590108 title "Acute-phase response protein serum amyloid A stimulates renal tubule formation: studies in vitro and in vivo" @default.
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• W2160590108 doi "https://doi.org/10.1152/ajprenal.90622.2008" @default.
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