FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160613893> ?p ?o ?g. }

• W2160613893 endingPage "59" @default.
• W2160613893 startingPage "1" @default.
• W2160613893 abstract "The response of the gill of Aplysia calfornica Cooper to weak to moderate tactile stimulation of the siphon, the gill-withdrawal response or GWR, has been an important model system for work aimed at understanding the relationship between neural plasticity and simple forms of non-associative and associative learning. Interest in the GWR has been based largely on the hypothesis that the response could be explained adequately by parallel monosynaptic reflex arcs between six parietovisceral ganglion (PVG) gill motor neurons (GMNs) and a cluster of sensory neurons termed the LE cluster. This hypothesis, the Kupfermann-Kandel model, made clear, falsifiable predictions that have stimulated experimental work for many years. Here, we review tests of three predictions of the Kupfermann-Kandel model: (1) that the GWR is a simple, reflexive behaviour graded with stimulus intensity; (2) that central nervous system (CNS) pathways are necessary and sufficient for the GWR; and (3) that activity in six identified GMNs is sufficient to account for the GWR. The available data suggest that (1) a variety of action patterns occur in the context of the GWR; (2) the PVG is not necessary and the diffuse peripheral nervous system (PNS) is sufficient to mediate these action patterns; and (3) the role of any individual GMN in the behaviour varies. Both the control of gill-withdrawal responses, and plasticity in these responses, are broadly distributed across both PNS and CNS pathways. The Kupfermann-Kandel model is inconsistent with the available data and therefore stands rejected. There is, no known causal connection or correlation between the observed plasticity at the identified synapses in this system and behavioural changes during non-associative and associative learning paradigms. Critical examination of these well-studied central pathways suggests that they represent a 'wetware' neural network, architecturally similar to the neural network models of the widely used 'Perceptron' and/or 'Back-propagation' type. Such models may offer a more biologically realistic representation of nervous system organisation than has been thought. In this model, the six parallel GMNs of the CNS correspond to a hidden layer within one module of the gill-control system. That is, the gill-control system appears to be organised as a distributed system with several parallel modules, some of which are neural networks in their own right. A new model is presented here which predicts that the six GMNs serve as components of a 'push-pull' gain control system, along with known but largely unidentified inhibitory motor neurons from the PVG. This 'push-pull' gain control system sets the responsiveness of the peripheral gill motor system. Neither causal nor correlational links between specific forms of neural plasticity and behavioural plasticity have been demonstrated in the GWR model system. However, the GWR model system does provide an opportunity to observe and describe directly the physiological and biochemical mechanisms of distributed representation and parallel processing in a largely identifiable 'wetware' neural network." @default.
• W2160613893 created "2016-06-24" @default.
• W2160613893 creator A5026988276 @default.
• W2160613893 creator A5045371685 @default.
• W2160613893 date "2004-02-01" @default.
• W2160613893 modified "2023-10-16" @default.
• W2160613893 title "Parallel processing in an identified neural circuit: the Aplysia californica gill-withdrawal response model system" @default.
• W2160613893 cites W126092559 @default.
• W2160613893 cites W1489116620 @default.
• W2160613893 cites W1499990132 @default.
• W2160613893 cites W1526183158 @default.
• W2160613893 cites W1543789537 @default.
• W2160613893 cites W1546869224 @default.
• W2160613893 cites W1597724381 @default.
• W2160613893 cites W176522371 @default.
• W2160613893 cites W1805012372 @default.
• W2160613893 cites W1856496911 @default.
• W2160613893 cites W1861409675 @default.
• W2160613893 cites W1910258660 @default.
• W2160613893 cites W1915026028 @default.
• W2160613893 cites W1923547763 @default.
• W2160613893 cites W193709421 @default.
• W2160613893 cites W1939219220 @default.
• W2160613893 cites W1945169718 @default.
• W2160613893 cites W1952921153 @default.
• W2160613893 cites W1964274714 @default.
• W2160613893 cites W1965018477 @default.
• W2160613893 cites W1971266177 @default.
• W2160613893 cites W1972097792 @default.
• W2160613893 cites W1972361029 @default.
• W2160613893 cites W1973022582 @default.
• W2160613893 cites W1974192130 @default.
• W2160613893 cites W1974732423 @default.
• W2160613893 cites W1977995918 @default.
• W2160613893 cites W1978012514 @default.
• W2160613893 cites W1979097070 @default.
• W2160613893 cites W1980382485 @default.
• W2160613893 cites W1980727985 @default.
• W2160613893 cites W1982859355 @default.
• W2160613893 cites W1985428865 @default.
• W2160613893 cites W1989011434 @default.
• W2160613893 cites W1989524456 @default.
• W2160613893 cites W1990525912 @default.
• W2160613893 cites W1990692420 @default.
• W2160613893 cites W1991071008 @default.
• W2160613893 cites W1995225326 @default.
• W2160613893 cites W1995887996 @default.
• W2160613893 cites W1999643558 @default.
• W2160613893 cites W2000383493 @default.
• W2160613893 cites W2004096730 @default.
• W2160613893 cites W2006179975 @default.
• W2160613893 cites W2009914957 @default.
• W2160613893 cites W2011483986 @default.
• W2160613893 cites W2012125473 @default.
• W2160613893 cites W2012550767 @default.
• W2160613893 cites W2014083159 @default.
• W2160613893 cites W2015386934 @default.
• W2160613893 cites W2016462314 @default.
• W2160613893 cites W2016703501 @default.
• W2160613893 cites W2019262588 @default.
• W2160613893 cites W2020989717 @default.
• W2160613893 cites W2021465868 @default.
• W2160613893 cites W2022830828 @default.
• W2160613893 cites W2024130819 @default.
• W2160613893 cites W2024443506 @default.
• W2160613893 cites W2025035251 @default.
• W2160613893 cites W2025805596 @default.
• W2160613893 cites W2028783129 @default.
• W2160613893 cites W2029303022 @default.
• W2160613893 cites W2032261246 @default.
• W2160613893 cites W2032745894 @default.
• W2160613893 cites W2033156681 @default.
• W2160613893 cites W2034765162 @default.
• W2160613893 cites W2035852681 @default.
• W2160613893 cites W2036290055 @default.
• W2160613893 cites W2036426006 @default.
• W2160613893 cites W2036521369 @default.
• W2160613893 cites W2038366302 @default.
• W2160613893 cites W2038608009 @default.
• W2160613893 cites W2038976574 @default.
• W2160613893 cites W2040870580 @default.
• W2160613893 cites W2043524695 @default.
• W2160613893 cites W2043553166 @default.
• W2160613893 cites W2044231631 @default.
• W2160613893 cites W2045273683 @default.
• W2160613893 cites W2045969413 @default.
• W2160613893 cites W2047305210 @default.
• W2160613893 cites W2053877642 @default.
• W2160613893 cites W2055848231 @default.
• W2160613893 cites W2056003475 @default.
• W2160613893 cites W2057716451 @default.
• W2160613893 cites W2058824452 @default.
• W2160613893 cites W2060981628 @default.
• W2160613893 cites W2063353423 @default.
• W2160613893 cites W2065755991 @default.
• W2160613893 cites W2066759812 @default.
• W2160613893 cites W2067397885 @default.
• W2160613893 cites W2069920493 @default.

• next