Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160616339> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2160616339 endingPage "442" @default.
- W2160616339 startingPage "431" @default.
- W2160616339 abstract "Summary Background Chronic use of NSAIDs is associated with gastrointestinal (GI) toxicity that increases with age. Aim To evaluate the GI safety and therapeutic efficacy of ibuprofen chemically associated with phosphatidylcholine (PC) in osteoarthritic (OA) patients. Methods A randomized, double‐blind trial of 125 patients was performed. A dose of 2400 mg/day of ibuprofen or an equivalent dose of ibuprofen‐PC was administered for 6 weeks. GI safety was assessed by endoscopy. Efficacy was assessed by scores of analgesia and anti‐inflammatory activity. Bioavailability of ibuprofen was pharmacokinetically assessed. Results Ibuprofen‐PC and ibuprofen provided similar bioavailability/therapeutic efficacy. In the evaluable subjects, a trend for improved GI safety in the ibuprofen‐PC group compared with ibuprofen that did not reach statistical significance was observed. However, in patients aged >55 years, a statistically significant advantage for ibuprofen‐PC treatment vs. ibuprofen in the prevention of NSAID‐induced gut injury was observed with increases in both mean Lanza scores and the risk of developing >2 erosions or an ulcer. Ibuprofen‐PC was well tolerated with no major adverse events observed. Conclusion Ibuprofen‐PC is an effective osteoarthritic agent with an improved GI safety profile compared with ibuprofen in older OA patients, who are most susceptible to NSAID‐induced gastroduodenal injury." @default.
- W2160616339 created "2016-06-24" @default.
- W2160616339 creator A5015089600 @default.
- W2160616339 creator A5039724841 @default.
- W2160616339 creator A5071002053 @default.
- W2160616339 creator A5076153292 @default.
- W2160616339 date "2008-07-23" @default.
- W2160616339 modified "2023-10-15" @default.
- W2160616339 title "Clinical trial: comparison of ibuprofen-phosphatidylcholine and ibuprofen on the gastrointestinal safety and analgesic efficacy in osteoarthritic patients" @default.
- W2160616339 cites W10412033 @default.
- W2160616339 cites W1964533656 @default.
- W2160616339 cites W1969901783 @default.
- W2160616339 cites W1981816788 @default.
- W2160616339 cites W2001350224 @default.
- W2160616339 cites W2010860405 @default.
- W2160616339 cites W2014976890 @default.
- W2160616339 cites W2045097647 @default.
- W2160616339 cites W2064312057 @default.
- W2160616339 cites W2083464592 @default.
- W2160616339 cites W2089107052 @default.
- W2160616339 cites W2090776502 @default.
- W2160616339 cites W2095127972 @default.
- W2160616339 cites W2096916760 @default.
- W2160616339 cites W2127778237 @default.
- W2160616339 cites W2142509332 @default.
- W2160616339 cites W2154807579 @default.
- W2160616339 cites W2163756514 @default.
- W2160616339 cites W2173164476 @default.
- W2160616339 cites W2321390295 @default.
- W2160616339 cites W2330496155 @default.
- W2160616339 cites W2396494909 @default.
- W2160616339 cites W2034986319 @default.
- W2160616339 doi "https://doi.org/10.1111/j.1365-2036.2008.03765.x" @default.
- W2160616339 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3353548" @default.
- W2160616339 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18549459" @default.
- W2160616339 hasPublicationYear "2008" @default.
- W2160616339 type Work @default.
- W2160616339 sameAs 2160616339 @default.
- W2160616339 citedByCount "61" @default.
- W2160616339 countsByYear W21606163392012 @default.
- W2160616339 countsByYear W21606163392013 @default.
- W2160616339 countsByYear W21606163392014 @default.
- W2160616339 countsByYear W21606163392015 @default.
- W2160616339 countsByYear W21606163392016 @default.
- W2160616339 countsByYear W21606163392017 @default.
- W2160616339 countsByYear W21606163392018 @default.
- W2160616339 countsByYear W21606163392019 @default.
- W2160616339 countsByYear W21606163392020 @default.
- W2160616339 countsByYear W21606163392022 @default.
- W2160616339 countsByYear W21606163392023 @default.
- W2160616339 crossrefType "journal-article" @default.
- W2160616339 hasAuthorship W2160616339A5015089600 @default.
- W2160616339 hasAuthorship W2160616339A5039724841 @default.
- W2160616339 hasAuthorship W2160616339A5071002053 @default.
- W2160616339 hasAuthorship W2160616339A5076153292 @default.
- W2160616339 hasBestOaLocation W21606163391 @default.
- W2160616339 hasConcept C126322002 @default.
- W2160616339 hasConcept C181389837 @default.
- W2160616339 hasConcept C197934379 @default.
- W2160616339 hasConcept C2779944601 @default.
- W2160616339 hasConcept C2780820201 @default.
- W2160616339 hasConcept C42219234 @default.
- W2160616339 hasConcept C535046627 @default.
- W2160616339 hasConcept C71924100 @default.
- W2160616339 hasConcept C90924648 @default.
- W2160616339 hasConcept C98274493 @default.
- W2160616339 hasConceptScore W2160616339C126322002 @default.
- W2160616339 hasConceptScore W2160616339C181389837 @default.
- W2160616339 hasConceptScore W2160616339C197934379 @default.
- W2160616339 hasConceptScore W2160616339C2779944601 @default.
- W2160616339 hasConceptScore W2160616339C2780820201 @default.
- W2160616339 hasConceptScore W2160616339C42219234 @default.
- W2160616339 hasConceptScore W2160616339C535046627 @default.
- W2160616339 hasConceptScore W2160616339C71924100 @default.
- W2160616339 hasConceptScore W2160616339C90924648 @default.
- W2160616339 hasConceptScore W2160616339C98274493 @default.
- W2160616339 hasIssue "4" @default.
- W2160616339 hasLocation W21606163391 @default.
- W2160616339 hasLocation W21606163392 @default.
- W2160616339 hasLocation W21606163393 @default.
- W2160616339 hasLocation W21606163394 @default.
- W2160616339 hasOpenAccess W2160616339 @default.
- W2160616339 hasPrimaryLocation W21606163391 @default.
- W2160616339 hasRelatedWork W1171142168 @default.
- W2160616339 hasRelatedWork W1964364835 @default.
- W2160616339 hasRelatedWork W1983113875 @default.
- W2160616339 hasRelatedWork W2000361523 @default.
- W2160616339 hasRelatedWork W202007074 @default.
- W2160616339 hasRelatedWork W2046280088 @default.
- W2160616339 hasRelatedWork W2313237820 @default.
- W2160616339 hasRelatedWork W2376626594 @default.
- W2160616339 hasRelatedWork W2381401049 @default.
- W2160616339 hasRelatedWork W2562722334 @default.
- W2160616339 hasVolume "28" @default.
- W2160616339 isParatext "false" @default.
- W2160616339 isRetracted "false" @default.
- W2160616339 magId "2160616339" @default.
- W2160616339 workType "article" @default.