Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160626758> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2160626758 startingPage "1208" @default.
- W2160626758 abstract "Introduction: Urinary biomarkers of pulmonary exacerbation in CF have not been as extensively studied as blood, sputum and bronchial fluid. However, urine collection is less invasive and would allow more frequent sampling at home or at point of care. This pilot study was intended to explore whether 24 rationally selected markers of inflammation were detectable in the urine of CF patients and healthy volunteers, and whether the levels of any of these were significantly different.Methods: 129 clinically stable CF patients (aged 6-68) attending the adult and paediatric CF centres in Belfast were recruited to the study. Some additional samples were collected at the start and/or end of antibiotic treatment of an infective exacerbation. 34 samples from healthy individuals (aged 24-60) were also included. Urinary biomarkers were measured with a combination of in-house assays (Mologic Ltd) and commercial assays (ELISA, lateral flow, substrate assays, zymography).Results: All 24 analytes were detectable in the urine samples, 10 were found to be significantly different in CF patient samples compared to healthy individuals (T test; p<0.05). TIMP2 and A1AT both protease inhibitors were excreted in the urine at significantly higher levels in the CF patients (p=0.001 and p=0.004 respectively) and fMLP, a chemotactic for neutrophils was significantly lower (p=<0.0001).Conclusion: Markers can be detected and quantified in urine. Further investigation is required to determine whether changes in levels of any of these can be used to predict exacerbation onset in order to instigate pre-emptive therapy.This study was supported by the UK Translational Research Partnership (TRP) and a US Ireland Partnership Grant." @default.
- W2160626758 created "2016-06-24" @default.
- W2160626758 creator A5005367733 @default.
- W2160626758 creator A5035751913 @default.
- W2160626758 creator A5048945685 @default.
- W2160626758 creator A5052945060 @default.
- W2160626758 creator A5054305635 @default.
- W2160626758 creator A5057834358 @default.
- W2160626758 creator A5064680897 @default.
- W2160626758 creator A5068087187 @default.
- W2160626758 creator A5075091144 @default.
- W2160626758 creator A5084570512 @default.
- W2160626758 date "2014-09-01" @default.
- W2160626758 modified "2023-09-27" @default.
- W2160626758 title "Inflammatory biomarkers in urine of cystic fibrosis patients" @default.
- W2160626758 hasPublicationYear "2014" @default.
- W2160626758 type Work @default.
- W2160626758 sameAs 2160626758 @default.
- W2160626758 citedByCount "0" @default.
- W2160626758 crossrefType "journal-article" @default.
- W2160626758 hasAuthorship W2160626758A5005367733 @default.
- W2160626758 hasAuthorship W2160626758A5035751913 @default.
- W2160626758 hasAuthorship W2160626758A5048945685 @default.
- W2160626758 hasAuthorship W2160626758A5052945060 @default.
- W2160626758 hasAuthorship W2160626758A5054305635 @default.
- W2160626758 hasAuthorship W2160626758A5057834358 @default.
- W2160626758 hasAuthorship W2160626758A5064680897 @default.
- W2160626758 hasAuthorship W2160626758A5068087187 @default.
- W2160626758 hasAuthorship W2160626758A5075091144 @default.
- W2160626758 hasAuthorship W2160626758A5084570512 @default.
- W2160626758 hasConcept C126322002 @default.
- W2160626758 hasConcept C142724271 @default.
- W2160626758 hasConcept C2776301714 @default.
- W2160626758 hasConcept C2776938444 @default.
- W2160626758 hasConcept C2777014857 @default.
- W2160626758 hasConcept C2779225474 @default.
- W2160626758 hasConcept C2780026642 @default.
- W2160626758 hasConcept C2781069245 @default.
- W2160626758 hasConcept C71924100 @default.
- W2160626758 hasConcept C77411442 @default.
- W2160626758 hasConcept C90924648 @default.
- W2160626758 hasConceptScore W2160626758C126322002 @default.
- W2160626758 hasConceptScore W2160626758C142724271 @default.
- W2160626758 hasConceptScore W2160626758C2776301714 @default.
- W2160626758 hasConceptScore W2160626758C2776938444 @default.
- W2160626758 hasConceptScore W2160626758C2777014857 @default.
- W2160626758 hasConceptScore W2160626758C2779225474 @default.
- W2160626758 hasConceptScore W2160626758C2780026642 @default.
- W2160626758 hasConceptScore W2160626758C2781069245 @default.
- W2160626758 hasConceptScore W2160626758C71924100 @default.
- W2160626758 hasConceptScore W2160626758C77411442 @default.
- W2160626758 hasConceptScore W2160626758C90924648 @default.
- W2160626758 hasLocation W21606267581 @default.
- W2160626758 hasOpenAccess W2160626758 @default.
- W2160626758 hasPrimaryLocation W21606267581 @default.
- W2160626758 hasRelatedWork W1441917974 @default.
- W2160626758 hasRelatedWork W1920889029 @default.
- W2160626758 hasRelatedWork W2003975902 @default.
- W2160626758 hasRelatedWork W2024889734 @default.
- W2160626758 hasRelatedWork W2030424308 @default.
- W2160626758 hasRelatedWork W2070127885 @default.
- W2160626758 hasRelatedWork W2079107579 @default.
- W2160626758 hasRelatedWork W2144165256 @default.
- W2160626758 hasRelatedWork W2189458891 @default.
- W2160626758 hasRelatedWork W2347932559 @default.
- W2160626758 hasRelatedWork W2401847788 @default.
- W2160626758 hasRelatedWork W2533537949 @default.
- W2160626758 hasRelatedWork W2549697779 @default.
- W2160626758 hasRelatedWork W2562276920 @default.
- W2160626758 hasRelatedWork W2770154728 @default.
- W2160626758 hasRelatedWork W2783550327 @default.
- W2160626758 hasRelatedWork W2905998439 @default.
- W2160626758 hasRelatedWork W2906165621 @default.
- W2160626758 hasRelatedWork W3106857603 @default.
- W2160626758 hasRelatedWork W3116490388 @default.
- W2160626758 hasVolume "44" @default.
- W2160626758 isParatext "false" @default.
- W2160626758 isRetracted "false" @default.
- W2160626758 magId "2160626758" @default.
- W2160626758 workType "article" @default.