Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160641761> ?p ?o ?g. }
- W2160641761 endingPage "566" @default.
- W2160641761 startingPage "556" @default.
- W2160641761 abstract "Mitral valve prolapse (MVP) may present with ventricular arrhythmias and sudden cardiac death (SCD) even in the absence of hemodynamic impairment. The structural basis of ventricular electric instability remains elusive.The cardiac pathology registry of 650 young adults (≤40 years of age) with SCD was reviewed, and cases with MVP as the only cause of SCD were re-examined. Forty-three patients with MVP (26 females; age range, 19-40 years; median, 32 years) were identified (7% of all SCD, 13% of women). Among 12 cases with available ECG, 10 (83%) had inverted T waves on inferior leads, and all had right bundle-branch block ventricular arrhythmias. A bileaflet involvement was found in 70%. Left ventricular fibrosis was detected at histology at the level of papillary muscles in all patients, and inferobasal wall in 88%. Living patients with MVP with (n=30) and without (control subjects; n=14) complex ventricular arrhythmias underwent a study protocol including contrast-enhanced cardiac magnetic resonance. Patients with either right bundle-branch block type or polymorphic complex ventricular arrhythmias (22 females; age range, 28-43 years; median, 41 years), showed a bileaflet involvement in 70% of cases. Left ventricular late enhancement was identified by contrast-enhanced cardiac magnetic resonance in 93% of patients versus 14% of control subjects (P<0.001), with a regional distribution overlapping the histopathology findings in SCD cases.MVP is an underestimated cause of arrhythmic SCD, mostly in young adult women. Fibrosis of the papillary muscles and inferobasal left ventricular wall, suggesting a myocardial stretch by the prolapsing leaflet, is the structural hallmark and correlates with ventricular arrhythmias origin. Contrast-enhanced cardiac magnetic resonance may help to identify in vivo this concealed substrate for risk stratification." @default.
- W2160641761 created "2016-06-24" @default.
- W2160641761 creator A5001136462 @default.
- W2160641761 creator A5004269363 @default.
- W2160641761 creator A5006248445 @default.
- W2160641761 creator A5010078370 @default.
- W2160641761 creator A5013227662 @default.
- W2160641761 creator A5015487544 @default.
- W2160641761 creator A5022167195 @default.
- W2160641761 creator A5031012881 @default.
- W2160641761 creator A5043401752 @default.
- W2160641761 creator A5044941375 @default.
- W2160641761 creator A5048411250 @default.
- W2160641761 creator A5057381638 @default.
- W2160641761 creator A5062631819 @default.
- W2160641761 creator A5067139776 @default.
- W2160641761 creator A5077749268 @default.
- W2160641761 creator A5081473643 @default.
- W2160641761 date "2015-08-18" @default.
- W2160641761 modified "2023-10-16" @default.
- W2160641761 title "Arrhythmic Mitral Valve Prolapse and Sudden Cardiac Death" @default.
- W2160641761 cites W1963839015 @default.
- W2160641761 cites W1968240609 @default.
- W2160641761 cites W1968645298 @default.
- W2160641761 cites W1971662974 @default.
- W2160641761 cites W1973145236 @default.
- W2160641761 cites W1980171293 @default.
- W2160641761 cites W1997869402 @default.
- W2160641761 cites W1998286016 @default.
- W2160641761 cites W1998704996 @default.
- W2160641761 cites W2001277680 @default.
- W2160641761 cites W2006798261 @default.
- W2160641761 cites W2006815949 @default.
- W2160641761 cites W2011813479 @default.
- W2160641761 cites W2013980680 @default.
- W2160641761 cites W2020530850 @default.
- W2160641761 cites W2020726715 @default.
- W2160641761 cites W2028062842 @default.
- W2160641761 cites W2028970020 @default.
- W2160641761 cites W2043748197 @default.
- W2160641761 cites W2043926420 @default.
- W2160641761 cites W2045857103 @default.
- W2160641761 cites W2051628450 @default.
- W2160641761 cites W2074246668 @default.
- W2160641761 cites W2087132532 @default.
- W2160641761 cites W2088351337 @default.
- W2160641761 cites W2092275130 @default.
- W2160641761 cites W2094025607 @default.
- W2160641761 cites W2094189169 @default.
- W2160641761 cites W2107558033 @default.
- W2160641761 cites W2110641913 @default.
- W2160641761 cites W2116340717 @default.
- W2160641761 cites W2117915730 @default.
- W2160641761 cites W2118953216 @default.
- W2160641761 cites W2126777002 @default.
- W2160641761 cites W2127522434 @default.
- W2160641761 cites W2127996216 @default.
- W2160641761 cites W2132285981 @default.
- W2160641761 cites W2133939580 @default.
- W2160641761 cites W2136516718 @default.
- W2160641761 cites W2142291451 @default.
- W2160641761 cites W2147139075 @default.
- W2160641761 cites W2155600522 @default.
- W2160641761 cites W2155802381 @default.
- W2160641761 cites W2172229267 @default.
- W2160641761 cites W2323812521 @default.
- W2160641761 cites W2336913884 @default.
- W2160641761 doi "https://doi.org/10.1161/circulationaha.115.016291" @default.
- W2160641761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26160859" @default.
- W2160641761 hasPublicationYear "2015" @default.
- W2160641761 type Work @default.
- W2160641761 sameAs 2160641761 @default.
- W2160641761 citedByCount "379" @default.
- W2160641761 countsByYear W21606417612014 @default.
- W2160641761 countsByYear W21606417612015 @default.
- W2160641761 countsByYear W21606417612016 @default.
- W2160641761 countsByYear W21606417612017 @default.
- W2160641761 countsByYear W21606417612018 @default.
- W2160641761 countsByYear W21606417612019 @default.
- W2160641761 countsByYear W21606417612020 @default.
- W2160641761 countsByYear W21606417612021 @default.
- W2160641761 countsByYear W21606417612022 @default.
- W2160641761 countsByYear W21606417612023 @default.
- W2160641761 crossrefType "journal-article" @default.
- W2160641761 hasAuthorship W2160641761A5001136462 @default.
- W2160641761 hasAuthorship W2160641761A5004269363 @default.
- W2160641761 hasAuthorship W2160641761A5006248445 @default.
- W2160641761 hasAuthorship W2160641761A5010078370 @default.
- W2160641761 hasAuthorship W2160641761A5013227662 @default.
- W2160641761 hasAuthorship W2160641761A5015487544 @default.
- W2160641761 hasAuthorship W2160641761A5022167195 @default.
- W2160641761 hasAuthorship W2160641761A5031012881 @default.
- W2160641761 hasAuthorship W2160641761A5043401752 @default.
- W2160641761 hasAuthorship W2160641761A5044941375 @default.
- W2160641761 hasAuthorship W2160641761A5048411250 @default.
- W2160641761 hasAuthorship W2160641761A5057381638 @default.
- W2160641761 hasAuthorship W2160641761A5062631819 @default.
- W2160641761 hasAuthorship W2160641761A5067139776 @default.