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- W2160656836 abstract "PURPOSE: The drug release from coated pellets depends on many process and formulation variables, including plasticization, curing treatment, and properties of the core. In this study, effect of currying on eudragit coated pellets was investigated. METHODS: Theophylline loaded pellets were coated with a non aqueous time and pH dependant eudragit solution. The coated pellets were cured at constant process parameters (45°C) for different time periods (05, 10, or 20 min) and the drug release profile and other characteristics of formulation were evaluated. RESULTS: In vitro release studies shows retardation of drug release from the coated pellets. The DSC thermogram revealed no interaction between the polymer and drug in the formulation. The SEM data shows no change in the surface topography after 20 min curing. CONCLUSION: In general, curing reduced the drug release and resulted in stable drug release profiles. Keywords: Time and pH dependant polymers, curing of pellets." @default.
- W2160656836 created "2016-06-24" @default.
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- W2160656836 date "2010-06-09" @default.
- W2160656836 modified "2023-10-14" @default.
- W2160656836 title "Effect of curing time on ph and time dependant coated pellets" @default.
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- W2160656836 doi "https://doi.org/10.4314/ijhr.v2i1.55394" @default.
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