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- W2160660853 abstract "Hyaluronic acid (HA) is a mucopolysaccharide acid composed of repeating disaccharide units of D-glucuronic acid and N-acetyl-D-glucosamine. Based on numerous characteristics such as viscoelastic properties, water-binding ability, biocompatibility and non-immunogenicity, HA has been approved by FDA for biological and medical applications. In addition, multifarious receptors of HA like CD44, RHAMM and TSG6 are over-expressed on the surface of malignant cells, which play important roles in targeting ability. Bioconjugates linking drugs to HA could improve solubility, prolong half-life, provide active targeting capability and then increase the bioavailability of these coupled drugs by pro-drug strategy. Therefore, a large number of HA-drug bioconjugates have been studied. The purpose of this review was to summarize these HA-drug bioconjugates and further discuss synthetic methods and the relevant application in pharmaceuticals." @default.
- W2160660853 created "2016-06-24" @default.
- W2160660853 creator A5031427654 @default.
- W2160660853 creator A5062886652 @default.
- W2160660853 creator A5070336572 @default.
- W2160660853 creator A5072266073 @default.
- W2160660853 date "2014-10-01" @default.
- W2160660853 modified "2023-09-23" @default.
- W2160660853 title "Current research on hyaluronic acid-drug bioconjugates" @default.
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- W2160660853 doi "https://doi.org/10.1016/j.ejmech.2014.08.067" @default.
- W2160660853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25173850" @default.
- W2160660853 hasPublicationYear "2014" @default.
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