Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160661041> ?p ?o ?g. }
- W2160661041 endingPage "40" @default.
- W2160661041 startingPage "34" @default.
- W2160661041 abstract "Maternal undernutrition (UN) is associated with the development of obesity and metabolic complications in adult offspring. This study investigated the impact of preweaning growth hormone (GH) treatment on adipocyte functionality in adult male offspring. Sprague-Dawley rats were assigned either standard (C) or undernourished (UN) diet (50% ad libitum) throughout gestation. Postnatal day 3–21, male C/UN pups received either saline (CS, UNS) or GH (2.5 µg/g/d; CGH, UNGH) by subcutaneous injection. Primary adipocytes were isolated following the collagenase digestion of adipose tissue. Primary adipocytes from UN offspring had significantly increased the secretion of pro-inflammatory cytokines accompanied by increased cytokine/cytokine receptor expression. This correlated with increased TLR4/NF-κB signaling. While increased inflammatory potential was not observed in adipocytes derived from UNGH offspring, there was a clear alteration in the expression of genes relating to carbohydrate and lipid metabolism along with nutrient transporters. Overall, preweaning GH treatment alters detrimental patterns of development, which predispose UN offspring to obesity and insulin resistance." @default.
- W2160661041 created "2016-06-24" @default.
- W2160661041 creator A5018662286 @default.
- W2160661041 creator A5036162325 @default.
- W2160661041 creator A5041600012 @default.
- W2160661041 creator A5091135495 @default.
- W2160661041 date "2014-01-07" @default.
- W2160661041 modified "2023-09-27" @default.
- W2160661041 title "Early-life growth hormone treatment to offspring of undernourished mothers alters metabolic parameters in primary adipocytes in adulthood" @default.
- W2160661041 cites W1968703258 @default.
- W2160661041 cites W1973024031 @default.
- W2160661041 cites W1982685226 @default.
- W2160661041 cites W1991401793 @default.
- W2160661041 cites W1997304834 @default.
- W2160661041 cites W2003810643 @default.
- W2160661041 cites W2006648944 @default.
- W2160661041 cites W2015403578 @default.
- W2160661041 cites W2021349238 @default.
- W2160661041 cites W2022544202 @default.
- W2160661041 cites W2022621797 @default.
- W2160661041 cites W2024212693 @default.
- W2160661041 cites W2035158829 @default.
- W2160661041 cites W2036021488 @default.
- W2160661041 cites W2069746141 @default.
- W2160661041 cites W2076770757 @default.
- W2160661041 cites W2085289521 @default.
- W2160661041 cites W2088940658 @default.
- W2160661041 cites W2094494860 @default.
- W2160661041 cites W2097459261 @default.
- W2160661041 cites W2102804274 @default.
- W2160661041 cites W2107277218 @default.
- W2160661041 cites W2110540949 @default.
- W2160661041 cites W2114949397 @default.
- W2160661041 cites W2117047882 @default.
- W2160661041 cites W2140498210 @default.
- W2160661041 cites W2143847855 @default.
- W2160661041 cites W2145792347 @default.
- W2160661041 cites W2146407048 @default.
- W2160661041 cites W2150004800 @default.
- W2160661041 cites W2156280702 @default.
- W2160661041 cites W2164721789 @default.
- W2160661041 cites W2167485774 @default.
- W2160661041 doi "https://doi.org/10.3109/08977194.2013.870169" @default.
- W2160661041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24392751" @default.
- W2160661041 hasPublicationYear "2014" @default.
- W2160661041 type Work @default.
- W2160661041 sameAs 2160661041 @default.
- W2160661041 citedByCount "6" @default.
- W2160661041 countsByYear W21606610412016 @default.
- W2160661041 countsByYear W21606610412017 @default.
- W2160661041 countsByYear W21606610412018 @default.
- W2160661041 crossrefType "journal-article" @default.
- W2160661041 hasAuthorship W2160661041A5018662286 @default.
- W2160661041 hasAuthorship W2160661041A5036162325 @default.
- W2160661041 hasAuthorship W2160661041A5041600012 @default.
- W2160661041 hasAuthorship W2160661041A5091135495 @default.
- W2160661041 hasConcept C112672928 @default.
- W2160661041 hasConcept C126322002 @default.
- W2160661041 hasConcept C134018914 @default.
- W2160661041 hasConcept C171089720 @default.
- W2160661041 hasConcept C2776175234 @default.
- W2160661041 hasConcept C2776659692 @default.
- W2160661041 hasConcept C2777391703 @default.
- W2160661041 hasConcept C2779234561 @default.
- W2160661041 hasConcept C511355011 @default.
- W2160661041 hasConcept C54355233 @default.
- W2160661041 hasConcept C71924100 @default.
- W2160661041 hasConcept C86803240 @default.
- W2160661041 hasConceptScore W2160661041C112672928 @default.
- W2160661041 hasConceptScore W2160661041C126322002 @default.
- W2160661041 hasConceptScore W2160661041C134018914 @default.
- W2160661041 hasConceptScore W2160661041C171089720 @default.
- W2160661041 hasConceptScore W2160661041C2776175234 @default.
- W2160661041 hasConceptScore W2160661041C2776659692 @default.
- W2160661041 hasConceptScore W2160661041C2777391703 @default.
- W2160661041 hasConceptScore W2160661041C2779234561 @default.
- W2160661041 hasConceptScore W2160661041C511355011 @default.
- W2160661041 hasConceptScore W2160661041C54355233 @default.
- W2160661041 hasConceptScore W2160661041C71924100 @default.
- W2160661041 hasConceptScore W2160661041C86803240 @default.
- W2160661041 hasIssue "1" @default.
- W2160661041 hasLocation W21606610411 @default.
- W2160661041 hasLocation W21606610412 @default.
- W2160661041 hasOpenAccess W2160661041 @default.
- W2160661041 hasPrimaryLocation W21606610411 @default.
- W2160661041 hasRelatedWork W1835582227 @default.
- W2160661041 hasRelatedWork W2017606817 @default.
- W2160661041 hasRelatedWork W2027098794 @default.
- W2160661041 hasRelatedWork W2048359366 @default.
- W2160661041 hasRelatedWork W2092567426 @default.
- W2160661041 hasRelatedWork W2125103862 @default.
- W2160661041 hasRelatedWork W2228231544 @default.
- W2160661041 hasRelatedWork W2547949331 @default.
- W2160661041 hasRelatedWork W2590309358 @default.
- W2160661041 hasRelatedWork W2998970372 @default.
- W2160661041 hasVolume "32" @default.
- W2160661041 isParatext "false" @default.
- W2160661041 isRetracted "false" @default.