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• W2160676038 startingPage "217" @default.
• W2160676038 abstract "Synthetic ligands of the retinoid X receptor (RXR) have shown antidiabetic activity in mice, apparently owing to the fact that they stimulate the transcriptional activity of PPAR-gamma/RXR heterodimers, much like thiazolidinedione drugs. The chlorophyll metabolite phytanic acid has been shown to be a natural ligand for RXR, active in concentrations near its physiological levels. It is thus reasonable to suspect that phytanic acid may have utility for treatment and prevention of human type 2 diabetes. Phytanic acid may mimic or complement various effects of conjugated linoleic acids, which have been shown to activate PPAR-gamma/RXR and prevent rodent diabetes. Administration of hydrolyzed chlorophyll may represent the most cost-effective strategy for raising human tissue levels of phytanic acid." @default.
• W2160676038 created "2016-06-24" @default.
• W2160676038 creator A5064469464 @default.
• W2160676038 date "2001-02-01" @default.
• W2160676038 modified "2023-10-17" @default.
• W2160676038 title "The chlorophyll metabolite phytanic acid is a natural rexinoid – potential for treatment and prevention of diabetes" @default.
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• W2160676038 doi "https://doi.org/10.1054/mehy.2000.1153" @default.
• W2160676038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11425290" @default.
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