FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160705488> ?p ?o ?g. }

• W2160705488 endingPage "20356" @default.
• W2160705488 startingPage "20351" @default.
• W2160705488 abstract "Integration sites for many retrotransposons and retroviruses are determined by interactions between retroelement-encoded integrases and specific DNA-bound proteins. The Saccharomyces retrotransposon Ty5 preferentially integrates into heterochromatin because of interactions between Ty5 integrase and the heterochromatin protein silent information regulator 4. We mapped over 14,000 Ty5 insertions onto the S. cerevisiae genome, 76% of which occurred in heterochromatin, which is consistent with the known target site bias of Ty5. Using logistic regression, associations were assessed between Ty5 insertions and various chromosomal features such as genome-wide distributions of nucleosomes and histone modifications. Sites of Ty5 insertion, regardless of whether they occurred in heterochromatin or euchromatin, were strongly associated with DNase hypersensitive, nucleosome-free regions flanking genes. Our data support a model wherein silent information regulator 4 tethers the Ty5 integration machinery to domains of heterochromatin, and then, specific target sites are selected based on DNA access, resulting in a secondary target site bias. For insertions in euchromatin, DNA access is the primary determinant of target site choice. One consequence of the secondary target site bias of Ty5 is that insertions in coding sequences occur infrequently, which may preserve genome integrity." @default.
• W2160705488 created "2016-06-24" @default.
• W2160705488 creator A5021762213 @default.
• W2160705488 creator A5049418431 @default.
• W2160705488 creator A5051580860 @default.
• W2160705488 date "2011-07-25" @default.
• W2160705488 modified "2023-10-16" @default.
• W2160705488 title "Access to DNA establishes a secondary target site bias for the yeast retrotransposon Ty5" @default.
• W2160705488 cites W1966903120 @default.
• W2160705488 cites W1966985571 @default.
• W2160705488 cites W1982616275 @default.
• W2160705488 cites W1993829493 @default.
• W2160705488 cites W2003425131 @default.
• W2160705488 cites W201532695 @default.
• W2160705488 cites W2018071194 @default.
• W2160705488 cites W2029957242 @default.
• W2160705488 cites W2031493137 @default.
• W2160705488 cites W2033400232 @default.
• W2160705488 cites W2034856837 @default.
• W2160705488 cites W2038070445 @default.
• W2160705488 cites W2040064091 @default.
• W2160705488 cites W2050194148 @default.
• W2160705488 cites W2054875735 @default.
• W2160705488 cites W2067852439 @default.
• W2160705488 cites W2069177029 @default.
• W2160705488 cites W2071880445 @default.
• W2160705488 cites W2079207401 @default.
• W2160705488 cites W2081323649 @default.
• W2160705488 cites W2082485360 @default.
• W2160705488 cites W2100270425 @default.
• W2160705488 cites W2103302926 @default.
• W2160705488 cites W2108483626 @default.
• W2160705488 cites W2108953735 @default.
• W2160705488 cites W2109818073 @default.
• W2160705488 cites W2110549387 @default.
• W2160705488 cites W2111118927 @default.
• W2160705488 cites W2115219137 @default.
• W2160705488 cites W2139205741 @default.
• W2160705488 cites W2144659717 @default.
• W2160705488 cites W2152014285 @default.
• W2160705488 cites W2152531069 @default.
• W2160705488 cites W2155776226 @default.
• W2160705488 cites W2156644035 @default.
• W2160705488 cites W4242156070 @default.
• W2160705488 cites W4294541781 @default.
• W2160705488 doi "https://doi.org/10.1073/pnas.1103665108" @default.
• W2160705488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3251128" @default.
• W2160705488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21788500" @default.
• W2160705488 hasPublicationYear "2011" @default.
• W2160705488 type Work @default.
• W2160705488 sameAs 2160705488 @default.
• W2160705488 citedByCount "23" @default.
• W2160705488 countsByYear W21607054882012 @default.
• W2160705488 countsByYear W21607054882013 @default.
• W2160705488 countsByYear W21607054882014 @default.
• W2160705488 countsByYear W21607054882016 @default.
• W2160705488 countsByYear W21607054882017 @default.
• W2160705488 countsByYear W21607054882018 @default.
• W2160705488 countsByYear W21607054882019 @default.
• W2160705488 countsByYear W21607054882020 @default.
• W2160705488 countsByYear W21607054882021 @default.
• W2160705488 countsByYear W21607054882022 @default.
• W2160705488 crossrefType "journal-article" @default.
• W2160705488 hasAuthorship W2160705488A5021762213 @default.
• W2160705488 hasAuthorship W2160705488A5049418431 @default.
• W2160705488 hasAuthorship W2160705488A5051580860 @default.
• W2160705488 hasBestOaLocation W21607054882 @default.
• W2160705488 hasConcept C100924687 @default.
• W2160705488 hasConcept C103435993 @default.
• W2160705488 hasConcept C104317684 @default.
• W2160705488 hasConcept C141231307 @default.
• W2160705488 hasConcept C4918238 @default.
• W2160705488 hasConcept C54355233 @default.
• W2160705488 hasConcept C552990157 @default.
• W2160705488 hasConcept C64927066 @default.
• W2160705488 hasConcept C7029365 @default.
• W2160705488 hasConcept C83640560 @default.
• W2160705488 hasConcept C84772758 @default.
• W2160705488 hasConcept C86803240 @default.
• W2160705488 hasConceptScore W2160705488C100924687 @default.
• W2160705488 hasConceptScore W2160705488C103435993 @default.
• W2160705488 hasConceptScore W2160705488C104317684 @default.
• W2160705488 hasConceptScore W2160705488C141231307 @default.
• W2160705488 hasConceptScore W2160705488C4918238 @default.
• W2160705488 hasConceptScore W2160705488C54355233 @default.
• W2160705488 hasConceptScore W2160705488C552990157 @default.
• W2160705488 hasConceptScore W2160705488C64927066 @default.
• W2160705488 hasConceptScore W2160705488C7029365 @default.
• W2160705488 hasConceptScore W2160705488C83640560 @default.
• W2160705488 hasConceptScore W2160705488C84772758 @default.
• W2160705488 hasConceptScore W2160705488C86803240 @default.
• W2160705488 hasIssue "51" @default.
• W2160705488 hasLocation W21607054881 @default.
• W2160705488 hasLocation W21607054882 @default.
• W2160705488 hasLocation W21607054883 @default.
• W2160705488 hasLocation W21607054884 @default.
• W2160705488 hasOpenAccess W2160705488 @default.
• W2160705488 hasPrimaryLocation W21607054881 @default.

• next